Role of Contrast Agent Perfusion and of Diffusion in the NMR Signal Enhancement of Liver Lesions

Marchal, G; Ni, Yicheng; Damme, Baudouin van; Hecke, Paul Van; Michiels, Johan; Yu, Jung‐Suk; Zhang, Xiaowei; Baert, A. L.

doi:10.1097/00004728-199209000-00004

Cited by 9 publications

(3 citation statements)

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“…In addition, the voxels with time-to-peak concentration in the third and fourth quartiles of the data tended to be those with K trans values near 0. This was expected, as voxels with late time-to-peak concentration are likely poorly-perfused and receive contrast agent largely through passive diffusion from neighboring voxels; results that are consistent with those previously reported (Jia et al, 2008, Pellerin et al, 2007, Marchal et al, 1992). The results from the experimental data show that the DTK model returns lower values for v e in the regions of the tumor with continuous and late delivery of CA.…”

Section: Discussionsupporting

confidence: 90%

A diffusion-compensated model for the analysis of DCE-MRI data: theory, simulations and experimental results

et al. 2013

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Accurate quantification of pharmacokinetic parameters in dynamic contrast-enhanced (DCE) MRI may be affected by the passive diffusion of contrast agent (CA) within the tissue. By introducing an additional term into the standard Tofts-Kety (STK) model, we correct for the effects of CA diffusion. We first develop the theory describing a CA diffusion corrected STK model (DTK). The model is then tested in simulation with simple models of diffusion. The DTK model is also fit to 18 in vivo DCE-MRI acquisitions from murine models of cancer and results are compared to those from the STK model. The DTK model returned estimates with significantly lower error than the STK model (p≪0.001). In poorly-perfused (i.e., Ktrans≤0.05 min−1) regions the STK model returned unphysical ve values, while the DTK model estimated ve with less than 7% error in noise-free simulations. Results in vivo data revealed similar trends. For voxels with low Ktrans values and late peak concentration times the STK model returned ve estimates >1.0 in 40% of the voxels as compared to only 16% for the DTK model. The DTK model presented here shows promise in estimating accurate kinetic parameters in the presence of passive contrast agent diffusion.

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Section: Discussionsupporting

confidence: 90%

A diffusion-compensated model for the analysis of DCE-MRI data: theory, simulations and experimental results

et al. 2013

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“…Cet effet T1 se rnanifeste essentiellement lors du skjour intravasculaire du produit. I1 rend donc compte de I'etat de la vascularisation du tissu observe (Josephson et al, 1988;Gore et Majurndar, 1990;Majurndar et al, 1990;Marchal et al, 1992). L'hyposignal du foie sain (contraste nCgatif) qui succede a cette phase correspond a un effet de susceptibilite rnagnetique du produit, mieux caractCrisC ?…”

Section: Discussionunclassified

“…Pour les 5 lapins du lot 11, quelque soit la sequence d'imagerie, il n'y a pas de diffkrence significative (ns) d'intensitk du signal entre le foie sain et le foie ischkmique T1 2 SE T2 t SE TF Foie sain 517 2 23 239 2 30 71 2 10 Foie ischkmique 529 2 19ns 233 2 2411s 77 2 lOns l'aide de sCquences pond6rCes en T2. Cet effet est plus marquC lors de la localisation intracellulaire du produit Majumdar et al, 1990;Marchal et al, 1992). Comme I'AMI 25 est captC par les cellules de Kupffer, cet effet T2 rend compte de I'intCgritC du systeme rkticulohistiocytaire.…”

Section: Discussionunclassified

Imagerie par Résonance Magnétique (IRM) fonctionnelle de l'ischémic hépatique chez le Lapin. Contribution d'un agent de contraste particulaire (AMI‐25)

Canet¹,

Roger²,

Chambon³

et al. 1996

Anat Histol Embryol

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A functional approach of the rabbit portal ischemia was performed on five New Zealand rabbits using magnetic-resonance (MR) imaging and an MR-specific contrast agent for the liver. The hepatic vascularization and the functionality of the phagocytosis cells were both studied with a single low dose of a unique contrast agent-superparamagnetic iron oxide particles (SPIOs). After a rapid i.v. injection of SPIOs, functional vessels and normally perfused liver parenchyma appeared with positive signal enhancement, whereas the ischemic area remained dark (cold spot). After the intravascular time period, the well-known negative enhancement induced by these particles on normal parenchyma was observed, with the difference of the ischemic liver, and could be related to the uptake of SPIOs by functional Kupffer cells.

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MR imaging of hypervascular liver tumors: Timing optimization during the arterial phase

Beers

Materne

Lacrosse

et al. 1999

J. Magn. Reson. Imaging

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Role of Contrast Agent Perfusion and of Diffusion in the NMR Signal Enhancement of Liver Lesions

Cited by 9 publications

References 0 publications

A diffusion-compensated model for the analysis of DCE-MRI data: theory, simulations and experimental results

A diffusion-compensated model for the analysis of DCE-MRI data: theory, simulations and experimental results

Imagerie par Résonance Magnétique (IRM) fonctionnelle de l'ischémic hépatique chez le Lapin. Contribution d'un agent de contraste particulaire (AMI‐25)

MR imaging of hypervascular liver tumors: Timing optimization during the arterial phase

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