Role of copeptin as a novel biomarker of bisphenol A toxic effects on cardiac tissues: biochemical, histological, immunohistological, and genotoxic study

Amin, Dalia M.

doi:10.1007/s11356-019-06855-8

Cited by 7 publications

(3 citation statements)

References 30 publications

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“…Comet assay is a sensitive and reliable technique for the detection of DNA damage in eukaryotic cells, which evaluates the genotoxicity of therapeutical interventions (Amin, 2019). In the present study, the comet assay was not performed for PE 50 and PE 100 once these groups showed an index of cell death higher than 70 % compared to control group in the viability test following the instructions of (Henderson, Wolfreys, Fedyk, Bourner, & Windebank, 1998).…”

Section: Discussionmentioning

confidence: 91%

In vitro and in vivo genotoxicity and cytotoxicity analysis of protein extract from Aplysina fulva sponges

Santana

Avanzi

Parisi

et al. 2021

Acta Sci. Biol. Sci.

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This study evaluated the physicochemical and morphological properties of a marine sponge protein extract (PE) using scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDS), analysis of mass loss and pH and in vitro and in vivo. Scanning electron microscopy showed that PE fibers present a granular aspect and irregular structure and the element carbon followed by oxygen was detected in the EDS analysis. Moreover, a 29% of mass loss was observed after 14 days and the pH slightly modified after 14 days. Cell viability of fibroblast cells (L929) of control and PE at a concentration of 25% demonstrated higher values compared to the groups. Osteoblast cell viability of PE at 25 and 50% was significantly higher. Comet assay on day 1 showed higher values for PE at 25%. In addition, in vivo experiments demonstrated that in the treated animals, the bone defects were filled with biomaterial particles, granulation tissue and some areas of newly formed bone. Furthermore, similar immunoexpression of Runx-2 and Cox-2 was observed. Taken together, all results suggest that PE is biocompatible, present non-citotoxicity in the in vitro studies (at the lower concentration) and in the in vivo studies and it can be considered as an alternative source of collagen for tissue engineering proposals.

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Section: Discussionmentioning

confidence: 91%

In vitro and in vivo genotoxicity and cytotoxicity analysis of protein extract from Aplysina fulva sponges

Santana

Avanzi

Parisi

et al. 2021

Acta Sci. Biol. Sci.

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“…Cardiac fibrosis: Cardiac fibrosis is induced by increased extracellular matrix deposition (e.g., collagen) and cardiac fibroblast activation and differentiation into myofibroblasts [218]. BPA exposure stimulates collagen deposition in the heart, which is associated with increased cardiac fibrosis [204,207,210,211,[219][220][221]. Moreover, BPA treatment increased collagen production in cardiac fibroblasts by activating ERK1/2 [222] but reduced cardiac remodeling after MI by increasing macrophage-induced inflammation and reducing myofibroblast repair function [203].…”

Section: Effects Of Bpa On Heart Tissuesmentioning

confidence: 99%

Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases

Kang,

Asai,

Toita

2023

JoX

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Bisphenol A (BPA; 4,4′-isopropylidenediphenol) is a well-known endocrine disruptor. Most human exposure to BPA occurs through the consumption of BPA-contaminated foods. Cardiovascular or cardiometabolic diseases such as diabetes, obesity, hypertension, acute kidney disease, chronic kidney disease, and heart failure are the leading causes of death worldwide. Positive associations have been reported between blood or urinary BPA levels and cardiovascular or cardiometabolic diseases. BPA also induces disorders or dysfunctions in the tissues associated with these diseases through various cell signaling pathways. This review highlights the literature elucidating the relationship between BPA and various cardiovascular or cardiometabolic diseases and the potential mechanisms underlying BPA-mediated disorders or dysfunctions in tissues such as blood vessels, skeletal muscle, adipose tissue, liver, pancreas, kidney, and heart that are associated with these diseases.

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“…It is synthesized as preprohormone (168 amino acids) in preoptic and paraventricular nuclei of hypothalamus which is broken down by a series of reactions mediated by endopeptidases, mononoxygenases and lyases respectively into prohormone. This segmentation is completed at level of neurohypophysis [12]. Stressful conditions in body stimulate various hormonal, autonomic and behavioral responses which are helpful in short term and long-term adaptation to stress.…”

mentioning

confidence: 99%

Maternal Serum Copeptin As a Biomarker For Intrauterine Growth Restriction

Hassan

Nasief

2021

PBMJ

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In obstetrical world, Intrauterine Growth Restriction (IUGR) occupies second slot as a cause of small for gestation neonates, first being premature birth, both of which result in potential neonatal morbidities and mortalities. IUGR is defined as an estimated fetal weight at one point in time at or below 10th percentile for gestational age. Annually about thirty million babies suffer from IUGR and out of these about 75% are Asians. IUGR has been found to be associated with increased levels of Copeptin. As copeptin is a marker of endogenous stress, so increased copeptin levels can indicate fetal and maternal stress in IUGR Objectives: The objectives of this study were to the compare maternal serum copeptin levels in pregnancies with IUGR and pregnancies with adequate for gestational age fetuses and to establish the significance of copeptin as a biomarker for IUGR. Methodology: It was a cross-sectional comparative study in which maternal serum copeptin levels were measured and compared in 60 patients divided in two groups, pregnancies with IUGR and normal pregnancies with adequate for gestation age fetuses between 28-35 weeks of gestation Results: Maternal serum copeptin levels were raised in pregnant women with IUGR as compared to that in pregnant women with adequate for gestational age fetuses. Mean ± SD maternal serum copeptin levels were 97.5 ± 6 pg/ml in pregnant women with AGA fetuses and 121 ± 7.8 pg/ml in pregnant women with IUGR. Conclusions: Maternal serum copeptin levels are raised in pregnancies with IUGR as compared to pregnancies with adequate for age fetuses which can represent as a possible clinical biomarker for identification of IUGR.

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Role of copeptin as a novel biomarker of bisphenol A toxic effects on cardiac tissues: biochemical, histological, immunohistological, and genotoxic study

Cited by 7 publications

References 30 publications

In vitro and in vivo genotoxicity and cytotoxicity analysis of protein extract from Aplysina fulva sponges

In vitro and in vivo genotoxicity and cytotoxicity analysis of protein extract from Aplysina fulva sponges

Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases

Maternal Serum Copeptin As a Biomarker For Intrauterine Growth Restriction

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