Role of copper in depression. Relationship with ketamine treatment

Słupski, Jakub; Cubała, Wiesław Jerzy; Górska, Natalia; Gałuszko-Węgielnik, Maria; Wiglusz, Mariusz S.

doi:10.1016/j.mehy.2018.07.012

Cited by 21 publications

(7 citation statements)

References 65 publications

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“…An increase in the levels of copper, on the other hand, will have a negative effect both through the modulation of zinc concentration, as well as directly, since copper ions inhibit the proper function of NEP. With regard to cognitive function, copper is also linked to certain psychiatric disorders, including depression [56]. Moreover, copper deficiency can be a cause of idiopathic myelopathy in adults [57,58,59].…”

Section: Copper Levels In Alcoholismmentioning

confidence: 99%

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review

et al. 2019

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The aim of this paper was to review recent literature (from 2000 onwards) and summarize the newest findings on fluctuations in the concentration of some essential macro- and microelements in those patients with a history of chronic alcohol abuse. The focus was mainly on four elements which the authors found of particular interest: Iron, magnesium, copper, and manganese. After independently reviewing over 50 articles, the results were consistent with regard to iron and magnesium. On the other hand, data were limited, and in some cases contradictory, as far as copper and manganese were concerned. Iron overload and magnesium deficiency are two common results of an excessive and prolonged consumption of alcohol. An increase in the levels of iron can be seen both in the serum and within the cells, hepatocytes in particular. This is due to a number of factors: Increased ferritin levels, lower hepcidin levels, as well as some fluctuations in the concentration of the TfR receptor for transferrin, among others. Hypomagnesemia is universally observed among those suffering from alcoholism. Again, the causes for this are numerous and include malnutrition, drug abuse, respiratory alkalosis, and gastrointestinal problems, apart from the direct influence of excessive alcohol intake. Unfortunately, studies regarding the levels of both copper and manganese in the case of (alcoholic) liver disease are scarce and often contradictory. Still, the authors have attempted to summarize and give a thorough insight into the literature available, bearing in mind the difficulties involved in the studies. Frequent comorbidities and mutual relationships between the elements in question are just some of the complications in the study of this topic.

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Section: Copper Levels In Alcoholismmentioning

confidence: 99%

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review

et al. 2019

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“…Organic acid transportation that contributes to depression has been found, and a blocking therapy of organic cation transporter has shown antidepressant efficacy in patients with depression (67). In addition, several transporters of mental ions such as copper and zinc have been confirmed to promote the development of depression (68,69).…”

Section: Discussionmentioning

confidence: 99%

Metabonomic Profile and Signaling Pathway Prediction of Depression-Associated Suicidal Behavior

Liu

2020

Front. Psychiatry

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Suicide is the most severe consequence of depression which has become a leading cause of disability and a global disease burden. Recent evidence indicates a central role of small molecules in the pathogenesis of depression and associated suicidal behaviors. However, there lacks a systemic exploration of small molecules in the development of depression-associated suicide, and it remains unclear how they affect an individual's behavior. In order to compare the metabonomic profiles between drug-naïve patients with depression-associated suicidal behaviors and healthy individuals, we conducted a systemic database search for studies of metabolic characteristics in depressionassociated suicidal behavior. Manual data curation and statistical analysis and integration were performed in Excel. We further performed an enrichment analysis of signaling pathway prediction using the Reactome Pathway Analysis tool. We have identified 17 metabolites that expressed differently between drug-naïve patients with depression-associated suicidal behaviors and healthy controls. We have integrated these metabolites into biological signaling pathways and provided a visualized signaling network in depressed suicidal patients. We have revealed that "transport of small molecules", "disease", "metabolism" and "metabolism of proteins" were the most relevant signaling sections, among which "transport of inorganic cations/anions and amino acids/ oligopeptides", "SLC-mediated transmembrane transport", and "metabolism of amino acids and derivatives" should be further studied to elucidate their potential pathogenic mechanism in the development of depression and associated suicidal behavior. In conclusion, our findings of these 17 metabolites and associated signaling pathways could provide an insight into the molecular pathogenesis of depression-associated suicidal behavior and potential targets for new drug inventions.

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“…There were two possible mechanisms explaining the development of depression. i) Binding of copper ions changes prion protein conformation, that might be playing an important role in regulation of NMDA receptors and development of depression (37) and ii) Imbalance of zinc and copper levels may modulate GABA, eventually leading to a lower concentration of neurotransmitter in the brain and contribute to depression (38).…”

Section: Discussionmentioning

confidence: 99%

Chronic copper exposure elicit neurotoxic responses in rat brain: Assessment of 8-hydroxy-2-deoxyguanosine activity, oxidative stress and neurobehavioral parameters

Kumar

Sathua

Flora

2019

Cell Mol Biol (Noisy-le-grand)

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Copper (Cu), one of the essential transition metal acts as a prosthetic group for variety of proteins and metalloenzymes. However, it may be hazardous when administered in excess. Copper induced memory impairment and progression of neurodegenerative diseases have not yet been fully elucidated. The aim of the present study was to investigate the effect of exposure to copper sulphate (10mg/kg and 20mg/kg body weight, daily for 16 weeks) on brain copper concentration, few biochemical parameters indicative of oxidative stress and on different neurobehavioral functions in male Sprague Dawley rats. Copper-administered animals showed significant increase in brain copper concentration and a depleted Ceruloplasmin level. Different neurobehavioral studies revealed impaired memory and motor coordination in copper exposed rat. Spontaneous locomotors activity and depression symptoms were also noted in copper intoxicated rats. 8-hydroxy-2' -deoxyguanosine (8-OHdG) level, one of the predominant forms of free radical-induced oxidative lesions, and has been widely used as a biomarker for oxidative stress, increased in copper treated group. Copper induced oxidative stress in the brain was also evident from the increased lipid per oxidation (LPO) and nitrite level, depletion of reduced glutathione (GSH), and reduced activities of the antioxidant enzymes such as superoxide dismutase (SOD), and catalase. The present study thus suggests a significant correlation between copper induced oxidative stress and changes in neurobehavioral function in rats. The changes were more pronounced in animals exposed to a higher dose of copper (20mg/kg) than the lower dose.

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Role of copper in depression. Relationship with ketamine treatment

Cited by 21 publications

References 65 publications

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review

Serum iron, Magnesium, Copper, and Manganese Levels in Alcoholism: A Systematic Review

Metabonomic Profile and Signaling Pathway Prediction of Depression-Associated Suicidal Behavior

Chronic copper exposure elicit neurotoxic responses in rat brain: Assessment of 8-hydroxy-2-deoxyguanosine activity, oxidative stress and neurobehavioral parameters

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