2017
DOI: 10.5604/01.3001.0010.3846
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Role of copper in the process of spermatogenesis

Abstract: Copper (Cu) is an essential trace element required for the normal development of living organisms. Due to its redox potential, copper is a cofactor in many enzymes responsible for important processes in cells. Copper deficiency has a significant influence on the reduction or the total eradication of copper-dependent enzymes in the body, thereby inhibiting cell life processes. On the other hand, copper is a very reactive element and in its free state, it can trigger the production of large amounts of free radic… Show more

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Cited by 33 publications
(32 citation statements)
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“…The role of trace elements in infertility is of great interest because many of them are co-factors in reproductive system involving epididymis and prostate [11]. Levels of Zn and Cu were low in infertile male patient compared with normal group P-value (0.000), this finding is agreement with a study done in national university of Singapore [12], also in accordance with other study conducted in Sudan [13].…”
Section: Discussionsupporting
confidence: 91%
“…The role of trace elements in infertility is of great interest because many of them are co-factors in reproductive system involving epididymis and prostate [11]. Levels of Zn and Cu were low in infertile male patient compared with normal group P-value (0.000), this finding is agreement with a study done in national university of Singapore [12], also in accordance with other study conducted in Sudan [13].…”
Section: Discussionsupporting
confidence: 91%
“…Oxidative stress, observed in 30%–80% of infertile men (Agarwal, Prabakaran, & Allamaneni, ; Aitken & Fisher, ; Bisht, Faiq, Tolahunase, & Dada, ), is defined as an imbalance between reactive oxygen species (ROS) levels and total antioxidant capacity (Gulum et al, ), in favour of the oxidative molecules (Sikka, ; Sikka, Rajasekaran, & Hellstrom, ). As it relates to male infertility, oxidative stress has been observed during spermatogenesis, after spermatogenesis, during epididymal maturation (Ogórek, Gąsior, Pierzchała, Daszkiewicz, & Lenartowicz, ) and after ejaculation (Wagner, Buettner, & Burns, ). ROS are molecular mediators and play pivotal roles in spermatozoa, where this phenomenon has been shown to participate in the many events that lead to fertilisation, such as sperm hyperactivation, capacitation, interaction to pellucid zone and acrosome reaction (Banihani, Abu‐Alhayjaa, Amarin, & Alzoubi, ; Moretti et al, ).…”
Section: Introductionmentioning
confidence: 99%
“…Copper is an essential element for most living organisms and plays an important role in physiological processes [185]. Needed in only trace amounts, the human body contains approximately 100 mg of copper [186].…”
Section: Coppermentioning
confidence: 99%