Role of Coprophagy in Utilization of Triglycerides, Calcium, Magnesium and Phosphorus in the Rat

Tadayyon, Bahram; Lutwak, Leo

doi:10.1093/jn/97.2.243

Cited by 19 publications

(5 citation statements)

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“…We previously reported that an increase of Ca absorption raised the Ca content of the femur in normal weaning rats (Ohta et al 1993). In contrast, Tadayyon & Lutwak (1968) reported that increased absorption of Ca did not raise the Ca content of the femur. Disagreement between these results may also be caused by differences in dietary conditions.…”

Section: Discussionmentioning

confidence: 88%

“…In the present study the prevention of coprophagy did not alter the absorption of Ca and Mg in rats which were allowed free access to the FO-free purified diet. Tadayyon & Lutwak (1968) reported that the prevention of coprophagy decreased the apparent absorptive ratios of both Ca and Mg by about 10 %. In their study the consumption of diet was restricted and rats were fed on diets containing several levels of Ca and P. Previously, we reported that increased Ca or P in the diet decreased the absorption of Mg markedly.…”

Section: Discussionmentioning

confidence: 99%

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Prevention of coprophagy modifies magnesium absorption in rats fed with fructo-oligosaccharides

Ohta¹,

Baba²,

Ohtsuki³

et al. 1996

Br J Nutr

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We developed a new type of anal cup for prevention of coprophagy and determined whether the absorption of Ca and Mg and the stimulatory effects of feeding fructo-oligosaccharides (FO) on the absorption of Ca and Mg were altered by prevention of coprophagy in rats. Rats were fed on a FOfree diet or a diet containing 50 g FO/kg for 2 weeks with or without prevention of coprophagy. FOfeeding increased the apparent absorptive ratio of Ca and Mg in rats with or without prevention of coprophagy. However, in the FO-fed groups the absorptive ratio of Mg in rats with prevention of coprophagy was higher than in rats withont prevention of coprophagy. The Ca content of the femur was higher in rats fed on the FO-diet than in rats fed on the FO-free diet both with and without coprophagy. In conclusion, FO-feeding increased the absorption of Ca and Mg in rats both with and without coprophagy. Moreover, prevention of coprophagy enhanced the absorption of Mg in rats fed with FO. Coprophagy has to be considered when the effects of luminal fermentation or mineral absorption are examined in rats.Coprophagy : Fructo-oligosaccharides : Calcium : Magnesium Coprophagy occurs in many rodent species (Giovannetti, 1982). In the laboratory rat, large amounts of excreted faeces are re-ingested. Coprophagy has a positive effect on the supply of vitamins (Schulze & Haenel, 1969) and the digestibility of minerals such as Fe (Neale, 1982) or Ca (Cree et al. 1986). Therefore, in rat experiments, coprophagy may lead to errors in the evaluation of nutrient absorption and digestibility when the results of these studies are extrapolated to humans. Therefore, it is important to examine the consequences of coprophagy on intestinal absorption of nutrients.We reported previously that a diet containing fructo-oligosaccharides (FO), increased the apparent absorption of Ca and Mg in rats. FO, which are not digestible by human enzymes, are fermented by luminal bacteria and stimulate the growth of bifidobacteria (Hidaka et al. 1991). The same effects have been observed with other indigestible carbohydrates, such as resistant starch (Schulz et al. 1993), lactulose (Heijnen et al. 1993 and inulin (Levrat et al. 1991). In all the previous studies the effects of indigestible carbohydrates were observed in rats that were allowed to practise coprophagy. However, there have been no observations of whether the stimulatory effects of such indigestible carbohydrates on mineral absorption occur in rats when coprophagy is prevented.available at https://www.cambridge.org/core/terms. https://doi

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Prevention of coprophagy modifies magnesium absorption in rats fed with fructo-oligosaccharides

Ohta¹,

Baba²,

Ohtsuki³

et al. 1996

Br J Nutr

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“…The weight difference between the C P --and the CPq-animals, which was found by Armstrong and Softly (1966) as well, has to be attributed chiefly to the prevention of CP and its consequences (Tadayyon and Lutwak, 1969). Both groups of animals had an absolutely equal food intake during the first 14 days, and an equal intake relative to their respective body weights during the last 3 days.…”

Section: Discussionmentioning

confidence: 76%

Influence of coprophagy prevented by partial immobilization on calcium metabolism and bone morphology in the rat

Remagen

Große

1974

Res. Exp. Med.

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Summary. We investigated the influence of coprophagy on the calcium metabolism of the rat. 20 experimental animals were prevented from coprophagy by wrapping them in leather harnesses and compared with 21 controls on the same food intake. Kinetics of calcium metabolism were analysed using 45Ca as tracer.The radiochemical results were compared with the histological observations in the epi-metaphyses of the knee joints.In the experimental animals prevented from coprophagy we found: 1. a highly significant lower body weight; 2. a highly significant diminution of the following parameters of calcium metabolism: compartment sizes and exchange rate between them, calcium excretion rates, bone accretion and resorption; 3. a narrower epiphyseal growth cartilage, clearly shorter and narrower primary trabeculae, rarefied secondary metaphyseal trabeculae.Histological alterations identical to those observed with coprophagy prevented, were found in 4 animals kept in harnesses but with coprophagy allowed.It is concluded that prevention of coprophagy has no measurable influence on the parameters of calcium metabolism.

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“…It is known that rats are a coprophagic species however, both the blind mole rats ( Spalax ehrenbergi ) and the normal rats are shown to exhibit place preference for its latrine to some extent . In this context, pudendal nerve transection in rats has been evaluated to assess the effect of neuropraxia on the external anal sphincter .…”

Section: Introductionmentioning

confidence: 99%

Behavioral outcomes of a novel, pelvic nerve damage rat model of fecal incontinence

Janssen

Breukink

Melenhorst

et al. 2017

Neurogastroenterology Motil

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Role of Coprophagy in Utilization of Triglycerides, Calcium, Magnesium and Phosphorus in the Rat

Cited by 19 publications

References 5 publications

Prevention of coprophagy modifies magnesium absorption in rats fed with fructo-oligosaccharides

Prevention of coprophagy modifies magnesium absorption in rats fed with fructo-oligosaccharides

Influence of coprophagy prevented by partial immobilization on calcium metabolism and bone morphology in the rat

Behavioral outcomes of a novel, pelvic nerve damage rat model of fecal incontinence

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