2012
DOI: 10.1161/circresaha.111.255745
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Role of Coronin 1B in PDGF-Induced Migration of Vascular Smooth Muscle Cells

Abstract: Rationale The type I subclass of Coronins, a family of actin binding proteins, regulates various actin dependent cellular processes including migration. However, the existence and role of coronins in vascular smooth muscle cell (VSMC) migration has yet to be determined. Objective The goal of the present study was to define the mechanism by which coronins regulate platelet-derived growth factor (PDGF)-induced VSMC migration. Methods and Results Coronin 1B (Coro1B) and 1C (Coro1C) were both found to be expre… Show more

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Cited by 25 publications
(25 citation statements)
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“…Cells were processed as previously described [26]. In short, cell were quickly washed with PBS, fixed with 10% formaldehyde for 10 min, rinsed with dH 2 O and permeabilized with 0.5% Triton-X-100 in PBS for 5 min.…”
Section: Methodsmentioning
confidence: 99%
“…Cells were processed as previously described [26]. In short, cell were quickly washed with PBS, fixed with 10% formaldehyde for 10 min, rinsed with dH 2 O and permeabilized with 0.5% Triton-X-100 in PBS for 5 min.…”
Section: Methodsmentioning
confidence: 99%
“…plays a role in platelet-derived growth factor-mediated smooth muscle cell migration and proliferation, 49 a pathway that has been studied for its potential as a target for therapy in PH. 55 HIST1H4C has been linked to proliferative pathways involving bone morphogenetic protein (BMP) and activin receptor-like kinase 1 (ALK-1).…”
Section: Coro1bmentioning
confidence: 99%
“…CORO1B inhibits actin filament nucleation and its downmodulation is required for smooth muscle cell migration. 39 Moreover, it is well known that RhoH is strictly required for cell migration in response to CXCL12. The diminished level of RhoH in monocytes treated with lenalidomide could impair the cellular distribution of phosphorylated focal adhesion kinase that fails to effectively co-ordinate the activation of the Rho GTPases RhoA and Rac, leading to defective migration.…”
Section: Discussionmentioning
confidence: 99%