Role of Corticosterone in Lipid Metabolism in Broiler Chick White Adipose Tissue

Honda, Kazuhisa; Kurachi, Kiyotaka; Takagi, Shoko; Saneyasu, Takaoki; Kamisoyama, Hiroshi

doi:10.2141/jpsa.0210060

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…On days 1,7,14,21,28,35,42,49, and 56, one broiler per replicate cage with a body weight close to the average was randomly selected and its body weight was checked; then, blood samples were collected from the wing vein and centrifuged at 3000× g for 15 min to collect serum samples and stored at −20 • C for later analysis. After that, these selected, yellow-feathered broilers were slaughtered by cervical dislocation, liver and abdominal adipose were quickly excised and weighted, about 1 g liver and abdominal adipose was rapidly collected into RNAase-free tubes, and then it was quickly frozen in liquid nitrogen and stored at −80 • C for later analysis.…”

Section: Sample Collectionmentioning

confidence: 99%

“…In other words, hepatic lipid metabolism as well as adipocyte hyperplasia and hypertrophy contribute to abdominal adipose deposition in broilers. The development of adipose tissue is regulated by various factors, including nutritional manipulation and hormonal and transcription factors [11][12][13][14]. In poultry, some experiments were conducted to evaluate lipid metabolism and abdominal adipose deposition in different broiler lines or weights [12,15,16].…”

Section: Introductionmentioning

confidence: 99%

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Age-Related Changes in Hepatic Lipid Metabolism and Abdominal Adipose Deposition in Yellow-Feathered Broilers Aged from 1 to 56 Days

Lan,

Wei,

et al. 2023

Animals

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The objective of this study was to evaluate the age-related changes in hepatic lipid metabolism, adipocyte hyperplasia, hypertrophy, and lipid metabolism in the abdominal adipose tissue of yellow-feathered broilers. Blood, liver, and abdominal adipose samples were collected on days 1, 7, 14, 21, 28, 35, 42, 49, and 56. Body, liver, and abdominal weight increased (p < 0.05) with age-related changes. The triacylglycerol content peaked on day 14, and total cholesterol content peaked on day 56. The adipocyte diameter and area peaked on day 56, and total DNA content peaked on day 7. The age-related changes in hepatic lipogenesis-related gene (ChREBP, SREBP-1c, ACC, FAS, SCD1) expression mainly occurred during days 1 to 21, hepatic lipolysis-related gene (CPT1, LPL, ApoB) expression mainly occurred during days 1 to 14, and abdominal adipose-deposition-related gene (PPARα, CPT1, LPL, PPARγ, C/EBPβ) expression occurred during days 1 to 14. These results demonstrated a dynamic pattern of hepatic lipid metabolism and abdominal adipose deposition in yellow-feathered broilers, which provides practical strategies to regulate hepatic lipid metabolism and reduce abdominal adipose deposition in yellow-feathered broilers.

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Section: Sample Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Age-Related Changes in Hepatic Lipid Metabolism and Abdominal Adipose Deposition in Yellow-Feathered Broilers Aged from 1 to 56 Days

Lan,

Wei,

et al. 2023

Animals

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“…Therefore, chronic CORT exposure decreased the protein expression of Beclin1, HSL and ATGL, indicating the inhibition of autophagy and lipolysis in the adipose tissues of chickens. Unlike acute GC exposure stimulating lipolysis in vivo [ 46 ], long-term GC administration induced adipocyte GR expression [ 30 ] and, in our study, suppressed the lipolytic capacity in chicken adipose tissues. Rapidly increasing plasma GC levels provides the basic energy demands to stress adaptation, while prolonged and high GC exposure could induce mitochondrial dysfunction [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 51%

m6A-Mediated PPARA Translational Suppression Contributes to Corticosterone-Induced Visceral Fat Deposition in Chickens

Zhou

Zhang

Liu

et al. 2022

IJMS

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Excess fat deposition in broilers leads to great economic losses and is harmful to consumers’ health. Chronic stress in the life cycle of chickens could be an important trigger. However, the underlying mechanisms are still unclear. In this study, 30-day-old chickens were subcutaneously injected with 2 mg/kg corticosterone (CORT) twice a day for 14 days to simulate long-term stress. It was shown that chronic CORT exposure significantly increased plasma triglyceride concentrations and enlarged the adipocyte sizes in chickens. Meanwhile, chronic CORT administration significantly enlarged the adipocyte sizes, increased the protein contents of FASN and decreased HSL, ATGL, Beclin1 and PPARA protein levels. Moreover, global m6A methylations were significantly reduced and accompanied by downregulated METTL3 and YTHDF2 protein expression by CORT treatment. Interestingly, the significant differences of site-specific m6A demethylation were observed in exon7 of PPARA mRNA. Additionally, a mutation of the m6A site in the PPARA gene fused GFP and revealed that demethylated RRACH in PPARA CDS impaired protein translation in vitro. In conclusion, these results indicated that m6A-mediated PPARA translational suppression contributes to CORT-induced visceral fat deposition in chickens, which may provide a new target for the treatment of Cushing’s syndrome.

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“…Poultry are sensitive to multiple psychological stressors, reviewed in [ 20 ], with the circulating concentrations of corticosterone having been reported to be increased by restraint [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ], withdrawal of feed [ 21 , 22 ] and exposure to Escherichia coli lipopolysaccharide [ 23 , 24 ] in chickens, as well as herding in turkeys [ 25 ]. The difficulty of attempting to transpose stress responses across species is exemplified by the different responses to shackling in chickens and turkeys, with marked increases in feather flapping and the circulating concentrations of corticosterone in chickens [ 26 , 27 ] but not in turkeys [ 24 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

“…The difficulty of attempting to transpose stress responses across species is exemplified by the different responses to shackling in chickens and turkeys, with marked increases in feather flapping and the circulating concentrations of corticosterone in chickens [ 26 , 27 ] but not in turkeys [ 24 , 27 ]. The activation of the HPA in chickens decreases growth [ 28 , 29 ] and enhances adiposity [ 30 ] and increases triglyceride lipase in the adipose tissue [ 22 ]. These effects are undesirable in poultry production.…”

Section: Introductionmentioning

confidence: 99%

Effects of Restraint Stress on Circulating Corticosterone and Met Enkephalin in Chickens: Induction of Shifts in Insulin Secretion and Carbohydrate Metabolism

Scanes,

Pierzchała-Koziec,

Gajewska

2024

Animals

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This study examined the effects of acute restraint stress in the presence or absence of naltrexone on the circulating concentrations of insulin, glucose, Met-enkephalin and corticosterone in 14-week-old chickens [design: 2 sex × 2 stress/non-stress × 2 +/− naltrexone]. In chickens (five male and five females per treatment) subjected to restraint for 30 min, there were increases in the plasma concentrations of corticosterone and Met-enkephalin. The plasma concentrations of insulin and glucose were also increased in the chickens during restraint. Moreover, there were increases in the plasma concentrations of insulin and glucose in the chickens. The patterns of expression of the proenkephalin gene (PENK) in both the anterior pituitary gland and the adrenal gland were very similar to that of plasma Met-enkephalin. There were relationships between the plasma concentrations of corticosterone, Met-enkephalin, insulin and glucose after 30 min of restraint. The effects of naltrexone treatment on both untreated and stressed chickens were also examined, with naltrexone attenuating the stress-induced increases in the plasma concentrations of corticosterone, Met-enkephalin and glucose but not in those of insulin. The present study demonstrates that stress increases insulin secretion in chickens but also induces insulin resistance.

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Role of Corticosterone in Lipid Metabolism in Broiler Chick White Adipose Tissue

Cited by 5 publications

References 36 publications

Age-Related Changes in Hepatic Lipid Metabolism and Abdominal Adipose Deposition in Yellow-Feathered Broilers Aged from 1 to 56 Days

Age-Related Changes in Hepatic Lipid Metabolism and Abdominal Adipose Deposition in Yellow-Feathered Broilers Aged from 1 to 56 Days

m6A-Mediated PPARA Translational Suppression Contributes to Corticosterone-Induced Visceral Fat Deposition in Chickens

Effects of Restraint Stress on Circulating Corticosterone and Met Enkephalin in Chickens: Induction of Shifts in Insulin Secretion and Carbohydrate Metabolism

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