Role of CT and MR imaging in predicting optimal cytoreduction of newly diagnosed primary epithelial ovarian cancer

The Use of CT Findings to Predict Extent of Tumor at Primary Surgery for Ovarian Cancer

“…Simultaneously, Gerestein et al examined 115 patients and found DPT and the presence of ascites to be most predictive [19]. Gemer et al performed validation measurements of several studies [10,[12][13][14] and found lack of confirmation of their metrics [20]. In addition to utilizing CT scan findings to predict suboptimal cytoreduction, others have attempted to predict ability to achieve an optimal cytoreduction using various preoperative tests, including non-CT imaging and CA-125 [12,13,15,[21][22][23][24][25].…”

“…This is in stark contrast to the use of CT scans to predict successful surgical debulking. Several studies have failed to show that CT findings can predict cytoreductive surgery outcomes across centers [10][11][12][13][14][15][16][17]. Subjective interpretation of CT findings and difficulty with standardized definitions have both been cited as minor contributors to this.…”

Neoadjuvant chemotherapy followed by surgical cytoreduction in advanced epithelial ovarian cancer

“…Many studies have shown good correlation between radiological and surgical staging, especially in advanced disease. [19,20] Qayyum et al [21] have shown a positive predictive value of 94% using CT scan for suboptimal cytoreduction in advanced ovarian cancer. CT scan was used in the current study for staging advanced ovarian cancer in majority of the patients and laparotomy was required for diagnosis and staging only in 25% of patients.…”

Role of CT scan-based and clinical evaluation in the preoperative prediction of optimal cytoreduction in advanced ovarian cancer: a prospective trial

“…However, the recent demonstration that CT predictors are not reliably reproducible in series different from the one(s) upon which the model was originated has questioned the true role of CT scan in predicting surgical outcome outside each own institution (Axtell et al, 2007). Additional sources of concern about the usefulness of CT imaging predictors are represented by the small size of previously published cohorts, often including early-stage cases, their retrospective nature, and heterogeneity of imaging procedures across institutions, as well as combinations of different CT predictors (Nelson et al, 1993;Forstner et al, 1995;Meyer et al, 1995;Bristow et al, 2000;Byrom et al, 2002;Dowdy et al, 2004;Qayyum et al, 2005;Axtell et al, 2007).…”