Role of CYP17 rs743572 Polymorphism in Benign Prostatic Hyperplasia: A Multivariate Integrated Analysis

Abstract

Objective: Many published studies have investigated the association between CYP17 rs743572 polymorphism and benign prostatic hyperplasia (BPH) susceptibility but have yielded inconsistent results. Hence, we performed this meta-analysis using the multivariate statistic method to address a more precise association. Methods: Case-control or cohort studies with adequate genotype distribution or minor allele frequency (MAF) were identified by searching the PubMed, Embase, and Web of Science databases up to December, 2018. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association between CYP17 rs743572 polymorphism and BPH susceptibility. Results: Pooled MAFs of 13 studies were 37% in Caucasians and 56% in Orientals, respectively. Pooled results of 8 studies suggested that CYP17 rs743572 was not associated with the BPH susceptibility in the overall population (OR = 0.98, 95% CI: 0.80–1.20 for A2 vs. A1; OR = 0.99, 95% CI: 0.79–1.25 for A1/A2 vs. A1/A1; OR = 0.97, 95% CI: 0.62–1.53 for A2/A2 vs. A1/A1). Sensitivity analysis showed the results were robust. Subgroup analysis based on ethnicity suggested that, in Orientals, A2 allele carriers had a 28% lower risk of developing BPH compared with A1 allele carriers, and the risk of BPH is 47% lower in A2/A2 genotype carriers compared with A1/A1 genotype carriers. No significant association was observed in Caucasians. Conclusion: In conclusion, our study indicates a negative association between CYP17 and BPH in Orientals. However, due to limited sample size, the conclusion should be interpreted with caution.

Systematic review and meta-analysis of candidate gene association studies of benign prostate hyperplasia

“…There is no consensus on the effect of genetic polymorphisms of these genes on BPH susceptibility. For example, the A1 allele with a gene dosage effect and -34T>C polymorphisms of CYP17 have been associated with an increased risk of BPH and its clinical progression, while no positive association was found in Orientals [ 49 ]. Similarly, the VDR gene polymorphism was not found significantly associated with BPH in Asians and Caucasians [ 18 ], whereas a significant association was demonstrated by two variants (Taq-I and Bsm-I) in Asians [ 15 ] and the other two variants (ApaI and BsmI) in Lebanese men [ 16 ].…”

The single-nucleotide polymorphism rs743572 of CYP17A1 shows significant association with polycystic ovary syndrome: a meta-analysis

“…Except for rs743572, other SNPs of CYP17A1 are rarely reported in PCOS (see Results). This single nucleotide polymorphism is a substitution with T to C in the 5 'untranslated region (Li et al, 2017) which gives rise to two variant genotypes 'CC' and 'CT'.Rs743572 mediates the regulation of gene expression (Rahimi and Mohammadi, 2019) and could enhance androgen synthesis (Weng et al, 2019). Initial characterization of this polymorphism was conducted by H. Carey, etc.…”