Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis

Sen, Alaattin; Stark, Holger

doi:10.3748/wjg.v25.i23.2846

Cited by 18 publications

(15 citation statements)

References 159 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…steroids) and exogenous (e.g. drugs) substances (59), was lower in the colonic enterocytes of patients suffering from Crohn's disease and ulcerative colitis (60). Our observation on Atlantic salmon also corroborates with this finding.…”

Section: Soy Products Also Impaired the Transport Mechanisms And Metasupporting

confidence: 88%

Intestinal Transcriptome Analysis Reveals Soy Derivative-Linked Changes in Atlantic Salmon

et al. 2020

View full text Add to dashboard Cite

Intestinal inflammation in farmed fish is a non-infectious disease that deserves attention because it is a major issue linked to carnivorous fishes. The current norm is to formulate feeds based on plant-derived substances, and the ingredients that have antinutritional factors are known to cause intestinal inflammation in fishes such as Atlantic salmon. Hence, we studied inflammatory responses in the distal intestine of Atlantic salmon that received a feed rich in soybean derivatives, employing histology, transcriptomic and flow cytometry techniques. The fish fed on soy products had altered intestinal morphology as well as upregulated inflammation-associated genes and aberrated ion transport-linked genes. The enriched pathways for the upregulated genes were among others taurine and hypotaurine metabolism, drug metabolism—cytochrome P450 and steroid biosynthesis. The enriched gene ontology terms belonged to transmembrane transporter- and channel-activities. Furthermore, soybean products altered the immune cell counts; lymphocyte-like cell populations were significantly higher in the whole blood of fish fed soy products than those of control fish. Interestingly, the transcriptome of the head kidney did not reveal any differential gene expression, unlike the observations in the distal intestine. The present study demonstrated that soybean derivatives could evoke marked changes in intestinal transport mechanisms and metabolic pathways, and these responses are likely to have a significant impact on the intestine of Atlantic salmon. Hence, soybean-induced enteritis in Atlantic salmon is an ideal model to investigate the inflammatory responses at the cellular and molecular levels.

show abstract

Section: Soy Products Also Impaired the Transport Mechanisms And Metasupporting

confidence: 88%

Intestinal Transcriptome Analysis Reveals Soy Derivative-Linked Changes in Atlantic Salmon

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Given that ulcerative colitis begins most commonly between the ages of 15 and 25 with a second peak of onset in the 6th decade of life, Mother's reported symptoms are concordant with her ulcerative colitis / bowel disease susceptibility. We also note that according to Sen and Stark ( 2019 ), CYP2D6 * 4 polymorphisms may be risk factors for ulcerative colitis. Both Mother and Daughter display CYP2D6 * 4 .…”

Section: Discussionsupporting

confidence: 55%

Whole Genome Interpretation for a Family of Five

et al. 2021

View full text Add to dashboard Cite

Although best practices have emerged on how to analyse and interpret personal genomes, the utility of whole genome screening remains underdeveloped. A large amount of information can be gathered from various types of analyses via whole genome sequencing including pathogenicity screening, genetic risk scoring, fitness, nutrition, and pharmacogenomic analysis. We recognize different levels of confidence when assessing the validity of genetic markers and apply rigorous standards for evaluation of phenotype associations. We illustrate the application of this approach on a family of five. By applying analyses of whole genomes from different methodological perspectives, we are able to build a more comprehensive picture to assist decision making in preventative healthcare and well-being management. Our interpretation and reporting outputs provide input for a clinician to develop a healthcare plan for the individual, based on genetic and other healthcare data.

show abstract

“…[91,92] Studies have shown that induction of colonic CYP27B1, enhancing the local production of 1,25(OH) 2 D 3 , is a protective mechanism for colonic inflammation. [93,94] Collectively, these data suggest that MCh may exert its anti-inflammatory action through inducing the production of 1,25(OH) 2 D 3 so as to protect the mucosal barrier and decrease colonic inflammation , though it might be an exaggerated inference but highly probable in the light of current literature. Further studies are required for a better understanding of the role of either CYP27B1 or 1,25(OH) 2 D 3 in the pathogenesis of UC.…”

Section: Discussionmentioning

confidence: 87%

Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis

Semiz

Acar

Çetin

et al. 2020

Journal of Translational Internal Medicine

Self Cite

View full text Add to dashboard Cite

Background and ObjectiveThis study was aimed to elucidate the molecular mechanism of Momordica charantia (MCh), along with a standard drug prednisolone, in a rat model of colitis induced by trinitrobenzene sulfonic acid (TNBS).MethodsAfter the induction of the experimental colitis, the animals were treated with MCh (4 g/kg/day) for 14 consecutive days by intragastric gavage. The colonic tissue expression levels of C-C motif chemokine ligand 17 (CCL-17), interleukin (IL)-1β, IL-6, IL-23, interferon-γ (IFN-γ), nuclear factor kappa B (NF-kB), and tumor necrosis factor-α (TNF-α), were determined at both mRNA and protein levels to estimate the effect of MCh. Besides, colonic specimens were analyzed histopathologically after staining with hematoxylin and eosin.ResultsThe body weights from TNBS-instigated colitis rats were found to be significantly lower than untreated animals. Also, the IFN-γ, IL-1β, IL-6, Il-23, TNF-α, CCL-17, and NF-kB mRNA and protein levels were increased significantly from 1.86-4.91-fold and 1.46-5.50-fold, respectively, in the TNBS-instigated colitis group as compared to the control. Both the MCh and prednisolone treatment significantly reduced the bodyweight loss. It also restored the induced colonic tissue levels of IL-1β, IL-6, IFN-γ, and TNF-α to normal levels seen in untreated animals. These results were also supported with the histochemical staining of the colonic tissues from both control and treated animals.ConclusionThe presented data strongly suggests that MCh has the anti-inflammatory effect that might be modulated through vitamin D metabolism. It is the right candidate for the treatment of UC as an alternative and complementary therapeutics.

show abstract

Role of cytochrome P450 polymorphisms and functions in development of ulcerative colitis

Cited by 18 publications

References 159 publications

Intestinal Transcriptome Analysis Reveals Soy Derivative-Linked Changes in Atlantic Salmon

Intestinal Transcriptome Analysis Reveals Soy Derivative-Linked Changes in Atlantic Salmon

Whole Genome Interpretation for a Family of Five

Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis

Contact Info

Product

Resources

About