Role of Cytokines and Chemokines in the Outcome of Children With Severe Asthma

Hatami, Hamed; Ghaffari, Negar; Ghaffari, Javad; Rafatpanah, Houshang

doi:10.32598/jpr.7.1.17

Cited by 8 publications

(9 citation statements)

References 61 publications

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“…В целом, первый является ключевым цитокином, продуцируемым преимущественно CD4+ Th2-лимфоцитами, тучными клетками и базофилами [31]. Он индуцирует не только продукцию IgE, но и экспрессию молекул главного комплекса гистосовместимости II класса, рецепторов В7 и CD40, а также мембранного IgM на поверхности В-лимфоцитов, тем самым увеличивая возможности антиген-презентирующих клеток.…”

Section: таблица 1 -клиническая эффективность рибомунила у детей с виunclassified

“…При этом известно, что повышение соотношения IL-4/ ИФНg в бронхо-альвеолярной жидкости, как правило, сопровождается увеличением количества Th2-лимфоцитов в дыхательных путях, что ассоциируется с более тяжелым течением астмы у детей [33]. Наряду с уровнем IL-5, ИФНg, GM-CSF (granulocyte-macrophage colony-stimulating factor, гранулоцитарно-макрофагальный колоние-стимулирующий фактор), показатели IL-4 являются значимыми биомаркерами тяжести аллергических заболеваний, в том числе, БА [31].…”

Section: таблица 1 -клиническая эффективность рибомунила у детей с виunclassified

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Clinical-Immunological Effectiveness of Ribomunyl in Children With Virus-Induced Bronchial Asthma

Белан

Никифорова

Заячникова

et al. 2020

Farm. farmakol. (Pâtigorsk)

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The aim of the study is to research the effects of immunostimulant Ribomunyl in virus-induced bronchial asthma (VBA) children.Materials and methods. 14 virus-induced bronchial asthma (VBA) children were agministrated with immunostimulant Ribomunyl as a part of complex therapy in a 18-month trial (3 cycles of treatment). The comparison group consisted of 16 patients who received only standard therapy for bronchial asthma. At the end of the study, against the background of basic BA therapy, the following parameters were estimated: the frequency of acute respiratory viral infections (ARVI), the need for antibacterial therapy, the frequency of IgG to respiratory-syncytial virus (RSV) prevalence, the serum level dynamics of total IgE, IFN-γ, interleukin-4 (IL-4), interferon gamma (IFN-γ).Results. The inclusion of Ribomunyl into the basic therapy complex in virus-induced bronchial asthma (VBA) children, made it possible to reduce the need for the VBA basic therapy complex by 50% and by 12,5% (р=0,0279). At the same time, as for the frequency of acute respiratory viral infections (ARVI), there was a comparable decrease in both groups, but in the main group the number of cases requiring antibiotic therapy decreased from 78.6% to 42.9% (p=0.0199). The inclusion of Ribomunyl into the basic therapy complex resulted in the decrease of the total IgE serum level; in the patients with the initial presence of IgG to the respiratory syncytial virus (RSV), the IL-4 level decreased and the IFN-γ level increased.Conclusion. Ribomunyl improves the treatment of virus-induced bronchial asthma (VBA) children, herewith the dynamics of immunological indicators is more in RSV-seropositive patients.

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Section: таблица 1 -клиническая эффективность рибомунила у детей с виunclassified

Clinical-Immunological Effectiveness of Ribomunyl in Children With Virus-Induced Bronchial Asthma

Белан

Никифорова

Заячникова

et al. 2020

Farm. farmakol. (Pâtigorsk)

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“…Reversible airflow obstruction, bronchial hyper-responsiveness, mucus hypersecretion, inflammatory cell migration into the airways, and structural airway remodeling due to cytokines and chemokines are characteristics of asthma. Some of cytokines and/ or chemokines are related to the severity of asthma and prediction of asthma (2,3). There is an association between anxiety in parents and the severity of their child's asthma (4).…”

Section: Contextmentioning

confidence: 99%

Maternal Serum IgE, Cord Blood IgE, and Children’s Allergy: A Narrative Review

2019

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Context: Asthma is chronic inflammatory disorder of the respiratory system in childhood. IgE has an important role in allergic disorders such as asthma. The aim of this study is to review the association between maternal serum IgE and incidence of childhood asthma. Evidence Acquisition: Three researchers searched all articles in PubMed, Scopus, Google and Embase databases related to maternal serum IgE, cord blood IgE, childhood asthma and incidence using key words such as maternal IgE, cord blood IgE, relation, association, childhood asthma, child allergy. Results: We found a few related articles on the topic of maternal IgE, cord blood IgE, and childhood asthma. We reviewed 11 articles for this study. Parental atopy and allergy are more important predictive factors for children's allergies such as asthma. IgE levels was higher in children whose mothers had higher IgE levels. Total IgE level was significantly higher in boys compared to girls. Conclusions: Increasing maternal and cord blood IgE may be a predictive factor for development of children asthma. More data is needed to clearify this relation.

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“…Asthma creates a high burden for the families and the country health system (4). The exact cause of asthma is unknown, but genetic and environmental factors play a role (5,6). Environmental factors include irritants; indoor and outdoor allergens play a key role in the development and stimulation of asthma symptoms (7).…”

Section: Introductionmentioning

confidence: 99%

House Dust Mite Allergen Levels of Der p1 and Der f1 in Houses of Asthmatic Children

et al. 2020

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Background: Exposure to house dust mites is an important cause of asthma among children. The main asthma-causing mites found in homes are Dermatophagoides farinae and Dermatophagoides. pteronyssinus. Der f1 or Der p1 are allergens of the mentioned mites. This study aimed to assess the levels of Der p1, and Der f1 in the homes of families that had a case of childhood asthma in a northern city of Iran and to determine the association between indoor house environment and the level of mites allergens present there. Objectives: This study aimed to evaluate House Dust Mite Allergen Levels of Der p1 and Der f1 in Houses of Asthmatic Children. Methods: Dust samples were collected from bedrooms of 91 homes of families that had cases of childhood asthma. Families filled a questionnaire about demographical characteristics and the indoor condition of their living environment. The levels of Der f1 and Der p1 were measured by enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed in SPSS v. 24 and a P-value less than 0.05 was considered significant. Results: we found that Der p1 was more prevalent than Der f1 among samples. The mean concentration of Der p1 concentration was 271.35 ng/g (9 times greater than the concentration of Der f1). When the indoor environment status was evaluated, it was found that keeping pets and having old carpets are associated with Der f1 (P<0.05). However, no significant association was found between Der p1 and the indoor conditions of the home. Conclusions: Our study showed that Der p1 level is higher than Der f1 level in the houses of children with asthma. We suggest removing carpets and pets from the house.

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Role of Cytokines and Chemokines in the Outcome of Children With Severe Asthma

Cited by 8 publications

References 61 publications

Clinical-Immunological Effectiveness of Ribomunyl in Children With Virus-Induced Bronchial Asthma

Clinical-Immunological Effectiveness of Ribomunyl in Children With Virus-Induced Bronchial Asthma

Maternal Serum IgE, Cord Blood IgE, and Children’s Allergy: A Narrative Review

House Dust Mite Allergen Levels of Der p1 and Der f1 in Houses of Asthmatic Children

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