Role of Cytotoxic T Lymphocytes in Murine Cytomegalovirus Infection

Involvement of Natural Killer Cells in the Pathogenesis of Murine Cytomegalovirus Interstitial Pneumonitis and the Immune Response to Infection

“…The cytotoxic responses were, in other respects, similar to those described previously in Balb/c mice Quinnan et al, 1978;Quinnan et al, 1980). Two components of the virus-specific cytotoxic response could be distinguished after i.p.…”

“…The only documented exception is the interferon response which begins on day 1, as demonstrated in the present study. The other specific responses which have been measured include CTL, from days 6 to 21 (Quinnan et al, 1978;Quinnan et aL, 1980), serum antibody which mediates antivirus antibody-dependent cell-mediated cytotoxicity (ADCC) beginning about day 10 (Manischewitz & Quinnan, 1980), serum neutralizing antibo.dy which develops about day 21 Wise et al, 1979) and a virus-specific lymphocyte proliferation response which develops about day 7 (Howard et al, 1977). It is not possible to exclude the possibility that local antibody production at the site of infected tissue begins at an earlier time, but this phenomenon has not been documented during this infection.…”

“…In a preliminary report, a similar response was noted during murine influenza virus infection (Daisy et al, 1980). In each case the response begins within 3 days of onset of infection and then wanes as an H-2-restricted cytotoxic T cell response begins, about 6 days after initiation of infection (Quinnan et al, 1978;Quinnan et al, 1980;Ennis et al, 1978;Zinkernagel & Doherty, 1974). In these infections the NK cell response is, thus, one of the earliest components of the immune response.…”

The Cytotoxic Response to Murine Cytomegalovirus. I. Parameters in vivo

“…The inability to detect direct cytotoxicity agrees with difficulties reported by other workers for MCMV (Ho, 1980) and HSV (Pfizenmaier et al, 1977), but is in contradistinction to others who were able to detect cytotoxicity to MCMV from two lymphoid populations, spleen and cervical LN after intraperitoneal and intranasal routes of inoculation respectively (Quinnan et al, 1978(Quinnan et al, , 1980. The discrepancy may be accounted for by technical differences in target cell and virus preparations and manipulations of variables such as mouse ages, route of inoculation and viral dose.…”

The role of natural killer cells and antibody-dependent cell-mediated cytotoxicity during murine cytomegalovirus infection.

“…This CTL response is virus-specific, H-2-restricted, and correlates temporally with the viremic phase of infection. During this time, CTL are distributed through the peripheral blood and in cervical lymph nodes (2). These earlier findings suggest that CTL may contribute significantly to the immune control of the acute, viremic phase of infection.…”