Role of Demineralized Allograft Subchondral Bone in the Treatment of Shoulder Lesions of the Talus: Clinical Results With Two-Year Follow-Up

Galli, Melissa M.; Protzman, Nicole M.; Bleazey, Scott T.; Brigido, Stephen A.

doi:10.1053/j.jfas.2014.05.008

Cited by 14 publications

(12 citation statements)

References 19 publications

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“… 19 , 20 Large lesions without a cartilage buttress are not proper for microfracture, given that osteochondral lesions of the talar shoulder are not suitable for microfracture. 21 , 22 However, further large-scale study is needed for the establishment of the exact indications. Nevertheless, we believe that arthroscopic microfracture can be an alternative treatment option to obtain the healing of defects and avoid external rotation limitation in young and active patients with recurrent dislocation with a LINE lesion.…”

Section: Discussionmentioning

confidence: 99%

Microfracture in Linear, Isolated, Narrow, Engaging Hill-Sachs Lesion

Yoo

Shin

Heo

et al. 2018

Arthroscopy Techniques

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Treatment of Hill-Sachs lesions is still controversial despite the frequent incidence in patients with recurrent shoulder dislocation. We report the use of arthroscopic microfracture for the treatment of recurrent shoulder dislocation with a linear, isolated, narrow, engaging Hill-Sachs lesion. Arthroscopic microfracture can be an alternative treatment option to obtain healing of defects and avoid external rotation limitation in young, active patients with recurrent dislocation with linear, isolated, narrow, engaging lesions.

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Section: Discussionmentioning

confidence: 99%

Microfracture in Linear, Isolated, Narrow, Engaging Hill-Sachs Lesion

Yoo

Shin

Heo

et al. 2018

Arthroscopy Techniques

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“…Clinically, DBM sponges have been used to treat osteochondral lesions of the talus and have been reported to cause no complications or immune reactions and have been reported to aid in alleviation of pain and disability (Bleazey and Brigado 2012;Galli et al 2014). NHS Blood and Transplant have developed a method of producing DBM sponges, Cell Tissue Bank using mineralised cancellous bone cubes as the starting material, which are compressible, non-cytotoxic and are osteoinductive when implanted intramuscularly into mice .…”

Section: Discussionmentioning

confidence: 99%

Development of an improved bone washing and demineralisation process to produce large demineralised human cancellous bone sponges

2015

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Shaped demineralised bone matrices (DBM) made from cancellous bone have important uses in orthopaedic and dental procedures, where the properties of the material allow its insertion into confined defects, therefore acting as a void filler and scaffold onto which new bone can form. The sponges are often small in size, <1.0 cm(3). In this study, we report on an improved bone washing and demineralisation process that allows production of larger DBM sponges (3.375 or 8.0 cm(3)) from deceased donor bone. These sponges were taken through a series of warm water washes, some with sonication, centrifugation, 100 % ethanol and two decontamination chemical washes and optimally demineralised using 0.5 N hydrochloric acid under vacuum. Demineralisation was confirmed by quantitative measurement of calcium and qualitatively by compression. Protein and DNA removal was also determined. The DBM sponges were freeze dried before terminal sterilisation with a target dose of 25 kGy gamma irradiation whilst frozen. Samples of the sponges were examined histologically for calcium, collagen and the presence of cells. The data indicated lack of cells, absence of bone marrow and a maximum of 1.5 % residual calcium.

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“…Nonetheless, there is some evidence that DBM can be beneficial in foot and ankle trauma [58][59][60]. In a study by Galli et al, the efficacy of 12 medial malleolar osteotomies with DBM subchondral bone grafting was evaluated as treatment for medial cystic, full thickness OCLs following failed microfracture.…”

Section: Demineralized Bone Matrixmentioning

confidence: 99%

“…Pain scores were shown to be significantly reduced between 6 and 24 months. In this study, disability was recorded as pain scores while ambulating up and down stairs, as well as walking for less than four blocks [58].…”

Section: Demineralized Bone Matrixmentioning

confidence: 99%

The role of biologic in foot and ankle trauma—a review of the literature

Zhao

Carney

Chambers

et al. 2018

Curr Rev Musculoskelet Med

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The most recent studies have shown benefits for biologic use in patients predisposed to poor bone and soft tissue healing. Biologics have shown benefit in treating soft tissue injuries such as Achilles ruptures as well as the complications of trauma such as non-unions and osteoarthritis. Biologics have shown some benefit in improving functional and pain scores, as well as reducing time to heal in foot and ankle traumatic injuries, with particular success shown with patients that have risk factors for poor healing. As the use of biologics continues to increase, there is a need for high-level studies to confirm early findings of lower level reports.

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Role of Demineralized Allograft Subchondral Bone in the Treatment of Shoulder Lesions of the Talus: Clinical Results With Two-Year Follow-Up

Cited by 14 publications

References 19 publications

Microfracture in Linear, Isolated, Narrow, Engaging Hill-Sachs Lesion

Microfracture in Linear, Isolated, Narrow, Engaging Hill-Sachs Lesion

Development of an improved bone washing and demineralisation process to produce large demineralised human cancellous bone sponges

The role of biologic in foot and ankle trauma—a review of the literature

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