Role of different types of nanomaterials against diagnosis, prevention and therapy of COVID-19

Ghaemi, Ferial; Amiri, Amirhassan; Bajuri, Mohd Yazid; Yuhana, Nor Yuliana; Феррара, Массимилиано

doi:10.1016/j.scs.2021.103046

Cited by 28 publications

(22 citation statements)

References 274 publications

(342 reference statements)

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“…The potential and different alternatives have been evaluated for the use of breath sensor technology in monitoring critically ill and COVID-19 patients. In fact, different types of nanomaterials have attracted the attention of the scientists in diagnosis, detection, monitoring, and therapy applications against COVID-19 [ 26 ]. Looking at the pathophysiology of COVID-19, there are several indicators that a coronavirus infection is detectable in the breath VOC pattern.…”

Section: Discussionmentioning

confidence: 99%

Breath Sensor Technology for the Use in Mechanical Lung Ventilation Equipment for Monitoring Critically Ill Patients

et al. 2022

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Background: The need for mechanical lung ventilation is common in critically ill patients, either with COVID-19 infection or due to other causes. Monitoring of patients being ventilated is essential for timely and improved management. We here propose the use of a novel breath volatile organic compound sensor technology to be used in a mechanical lung ventilation machine for this purpose; the technology was evaluated in critically ill COVID-19 patients on mechanical lung ventilation. Methods: Based on the consistency results of our study data, the breath sensor device with metal oxide gas sensors and environment-controlling sensors was mounted on the ventilation exhaust port of the ventilation machine; this allowed to ensure additional safety since the device was placed outside the contour between the patient and equipment. Results: The sensors allowed stable registration of the signals for up to several weeks for 10 patients in total, depending on the storage amount; a proportion of patients were intubated or received tracheostoma during the evaluation period. Future studies are on the way to correlate sensor readings to other parameters characterizing the severity of the patient condition and outcome. Conclusions: We suppose that such technology will allow patient monitoring in real-time for timely identification of deterioration, potentially requiring some change of management. The obtained results are preliminary and further studies are needed to examine their clinical significance.

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Section: Discussionmentioning

confidence: 99%

Breath Sensor Technology for the Use in Mechanical Lung Ventilation Equipment for Monitoring Critically Ill Patients

et al. 2022

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“…As a result, damaged cell membrane (coenzyme A) disturbed the cellular respiration, other biochemical systems, and ultimately cause cell lysis ( Ghotekar et al, 2021 ; Bandala et al, 2021 ). Depending upon the complexity of the virus structure, the comprehensive degradation mechanism involves; (a) the peroxidation of proteins, lipids by radicles that depresses the periplasmic enzyme activity and damage the genetic RNA material; (b) release of metal ions (photocatalyst) into the cell that interacts with COOH, –NH, –SH like functional groups to damage nucleic acids; and (c) disturbing the cellular metabolism without the induction of oxidative stress ( Li et al, 2020a ; Ghaemi et al, 2021 ). Thus, understanding the deactivation mechanism of viruses might be helpful to construct more superior potential photocatalytic materials with apt morphology and practical importance.…”

Section: Photocatalytic Performance Evaluation On Virus Disinfectionmentioning

confidence: 99%

Current perspective in metal oxide based photocatalysts for virus disinfection: A review

Soni

Khosla

Singh

et al. 2022

Journal of Environmental Management

103

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Nanotechnology holds huge potential for the prevention of various viral outbreaks that have increased at a disquieting rate over the past decades. Metal oxide nanomaterials with oxidative capability are the effective materials that provide platforms as well as tools for the well understanding of the mechanism, its detection, and treatment of various viral diseases like measles, influenza, herpes, ebola, current COVID-19 etc. In this inclusive review, we survey various previous research articles on different notable photoactive transition metal oxides that possess enough potential to act as antiviral agents for the deactivation of harmful viruses. We investigated and highlighted the plausible photocatalytic oxidative mechanism of photoactive transition metal oxides in degrading viral coatings, genomic RNA using suitable free radical generation. The key finding of the present review article including the discovery of a vision on the suitable photocatalytic transition metal oxides that have been proven to be excellent against harmful viruses and consequently combatting deadly CoV-2 in the environment. This review intends to provide conclusive remarks and a realistic outlook on other advanced photocatalytic metal oxides as a potential solution in battling other similar upcoming pandemics.

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“…In this case, lipidic formulations and polymeric nanoparticles can be used as carriers, as their size, morphology and charge are tailored according the particular situation [ 251 , 252 , 253 , 254 , 255 , 256 ]. In a very recent review, Ghaemi et al [ 257 ] highlighted the most used nanomaterials/nanoparticles with high potential in therapy, prevention and detection of targeted virus proteins: carbon nanotubes, graphene and graphene oxide, fullerene, quantum dots, CuNPs, ZnNPs, AgNPs, TiO 2 and chitosan NPs. They concluded that the inclusion of nanomaterials in biosensors offer more detection capability, stability, simplicity of design, reliability and affordability.…”

Section: Metal Nanoparticles and Carbon-based Nanomaterials In (Bio)sensors Designmentioning

confidence: 99%

“…The antigen lateral flow detection of SARS-CoV-2 as a point-of-care approach is realized by using a membrane strip with two lines: first line for the antibody-Au NPs, and second line for the captured antibodies. Biological samples such as blood or urine samples can be applied on the membrane, while, based on the capillary mechanism, proteins are drawn across the strip and an antigen/antibody AuNPs complex is formed and immobilized, a pair of red or blue lines becoming evident [ 257 , 264 ].…”

Section: Metal Nanoparticles and Carbon-based Nanomaterials In (Bio)sensors Designmentioning

confidence: 99%

Metal Nanoparticles and Carbon-Based Nanomaterials for Improved Performances of Electrochemical (Bio)Sensors with Biomedical Applications

et al. 2021

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Monitoring human health for early detection of disease conditions or health disorders is of major clinical importance for maintaining a healthy life. Sensors are small devices employed for qualitative and quantitative determination of various analytes by monitoring their properties using a certain transduction method. A “real-time” biosensor includes a biological recognition receptor (such as an antibody, enzyme, nucleic acid or whole cell) and a transducer to convert the biological binding event to a detectable signal, which is read out indicating both the presence and concentration of the analyte molecule. A wide range of specific analytes with biomedical significance at ultralow concentration can be sensitively detected. In nano(bio)sensors, nanoparticles (NPs) are incorporated into the (bio)sensor design by attachment to the suitably modified platforms. For this purpose, metal nanoparticles have many advantageous properties making them useful in the transducer component of the (bio)sensors. Gold, silver and platinum NPs have been the most popular ones, each form of these metallic NPs exhibiting special surface and interface features, which significantly improve the biocompatibility and transduction of the (bio)sensor compared to the same process in the absence of these NPs. This comprehensive review is focused on the main types of NPs used for electrochemical (bio)sensors design, especially screen-printed electrodes, with their specific medical application due to their improved analytical performances and miniaturized form. Other advantages such as supporting real-time decision and rapid manipulation are pointed out. A special attention is paid to carbon-based nanomaterials (especially carbon nanotubes and graphene), used by themselves or decorated with metal nanoparticles, with excellent features such as high surface area, excellent conductivity, effective catalytic properties and biocompatibility, which confer to these hybrid nanocomposites a wide biomedical applicability.

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Role of different types of nanomaterials against diagnosis, prevention and therapy of COVID-19

Abstract: Graphical Abstracts

Cited by 28 publications

References 274 publications

Breath Sensor Technology for the Use in Mechanical Lung Ventilation Equipment for Monitoring Critically Ill Patients

Breath Sensor Technology for the Use in Mechanical Lung Ventilation Equipment for Monitoring Critically Ill Patients

Current perspective in metal oxide based photocatalysts for virus disinfection: A review

Metal Nanoparticles and Carbon-Based Nanomaterials for Improved Performances of Electrochemical (Bio)Sensors with Biomedical Applications

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