Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications

Sahu, Bijayashree; Tikoo, Ojas; Pati, Benudhara; Senapati, Unmod; Bal, Naresh C.

doi:10.1007/112_2022_73

Cited by 9 publications

(6 citation statements)

References 278 publications

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“…40,41 Physical activity is also suggested to modulate the secretion of many contraction-associated myokines. 18 One of these, myostatin accumulation, is another plausible cause for InR-induced skeletal muscle wasting and fat accumulation in mice. 42 In our study, an increased circulatory concentration of this in SED is associated with loss of muscle protein due to fat storage.…”

Section: Discussionmentioning

confidence: 99%

“…Secretion of these during or after exercise depends on the duration of activity and the site of secretion to play inflammatory and anti-inflammatory roles. [17][18][19] These changes in metabolism are closely associated with the molecular adaptation of organs to the molecules in the systemic circulation (energysensing metabolites and cytokines).…”

Section: Introductionmentioning

confidence: 99%

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Long-term physical inactivity induces significant changes in biochemical pathways related to metabolism of proteins and glycerophospholipids in mice

Sahu,

Pani,

Swalsingh

et al. 2024

Mol. Omics

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long-term physical inactivity induces significant changes in biochemical pathways related to metabolism of proteins and glycerophospholipids in mice

Sahu,

Pani,

Swalsingh

et al. 2024

Mol. Omics

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“…Leptin, a neuromodulator protein formed predominantly in the white subcutaneous adipose tissue is a crucial body-weight regulator in the human feeding and satiety cycle [35,36]. Leptin sends satiety impulses to the hypothalamus and thus decreasing food intake and fat storage while ensuring modulation of energy expenditure and carbohydrate metabolism, and finally averting excessive weight gain [37].…”

Section: Etiology Of Obesitymentioning

confidence: 99%

Obesity: A Prerequisite for Major Chronic Illnesses

Abiola Afolabi,

Zakaria,

Md. Salleh

et al. 2023

Obesity - Recent Insights and Therapeutic Options

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Obesity is rampantly soaring at an alarming rate globally and simultaneously causing an increased incidence, and predisposition to various comorbidities. obesity is body mass index of >30kg/m2, while <18kg/m2 is underweight. The world at large fails to recognize obesity as an inevitable disease that requires strict measures to control this modifiable risk factor. W.H.O news release reported that over one billion people globally are obese among which 650 million were adults, 340 million were adolescents, and 39 million were children. The lowest obesity prevalence was reported in Timor Leste at 3.80%, Bangladesh at 3.60%, and Vietnam at 2.10% while the highest were noted in Nauru at 61%, cook island at 55.9%, and Palau at 55.3%. obesity is the most prevailing health problem (15% globally) associated with an increased propensity for development of several medical illnesses, obesity-associated adverse outcomes causing fatal complications that are difficult to manage, and premature mortality. The obese often feel they are not socially cared for by society and are accorded limited time by physicians who don’t view their health concerns from their own perspectives. Thus, making them pessimistic from low self-esteem and discrimination, body shaming, and stigmatization. They eventually develop depressive-anxiety disorder because of distrust insight.

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“…Recent studies have shown that myocytes and brown adipocytes are both derived from mesenchymal stem cells and share similar precursor transcriptomes (Bal et al, 2016;Bal et al, 2017;Scheele and Wolfrum, 2020;Pan and Chen, 2021;Sahu et al, 2023), and both BAT and skeletal muscle use energy substrates including fat and glucose, as fuel to generate heat (Pani et al, 2022). From a metabolic perspective, the thermogenesis of BAT and skeletal muscle is in a dynamic balance.…”

Section: Introductionmentioning

confidence: 99%

The crosstalk between BAT thermogenesis and skeletal muscle dysfunction

Chen

Wang

et al. 2023

Front. Physiol.

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Metabolic defects increase the risk of skeletal muscle diseases, and muscle impairment might worsen metabolic disruption, leading to a vicious cycle. Both brown adipose tissue (BAT) and skeletal muscle play important roles in non-shivering thermogenesis to regulate energy homeostasis. BAT regulates body temperature, systemic metabolism, and seretion of batokines that have positive or negative impacts on skeletal muscle. Conversely, muscle can secrete myokines that regulate BAT function. This review explained the crosstalk between BAT and skeletal muscle, and then discussed the batokines and highlighted their impact on skeletal muscle under physiological conditions. BAT is now considered a potential therapeutic target for obesity and diabetes treatment. Moreover, manipulation of BAT may be an attractive approach for the treatment of muscle weakness by correcting metabolic deficits. Therefore, exploring BAT as a potential treatment for sarcopenia could be a promising avenue for future research.

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Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications

Cited by 9 publications

References 278 publications

Long-term physical inactivity induces significant changes in biochemical pathways related to metabolism of proteins and glycerophospholipids in mice

Long-term physical inactivity induces significant changes in biochemical pathways related to metabolism of proteins and glycerophospholipids in mice

Obesity: A Prerequisite for Major Chronic Illnesses

The crosstalk between BAT thermogenesis and skeletal muscle dysfunction

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