Role of DJ-1 in parkinson’s disease

Lev, Nirit; Roncevich, Dusan; Ickowicz, Debby; Melamed, Eldad; Offen, Daniel

doi:10.1385/jmn:31:03:307

Cited by 31 publications

(5 citation statements)

References 78 publications

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“…Mutations in the DJ1 and LRRK2 genes are associated with decreased mitochondrial membrane potential, increased oxidative stress, decreased complex I function, and increased mitochondrial fragmentation. (36,37) Neuroprotective effects of fucoxanthin Fucoxanthin (C 42 H 58 O 6 ) is a carotenoid marine xanthophyll that is found in brown seaweed such as Undaria pinnatifida and Laminaria japonica. (38,39) It has a strong antioxidant capacity because of the presence of multiple double bonds, including a conjugated carbonyl group.…”

Section: Mitochondrial Dysfunction In Brain Disordersmentioning

confidence: 99%

“…(69) Similarly, DJ1 and LRRK2 gene mutations are associated with loss of mitochondrial membrane potential and morphology. (36,37) DJ1 binds to the β-subunit of the F1Fo ATP synthase enhancing ATP production. In contrast, a DJ1 mutant fails to close the mitochondrial inner membrane leak, thereby altering energy metabolism.…”

Section: Mitochondrial Dysfunction In Brain Disordersmentioning

confidence: 99%

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Mitochondrial protective potential of fucoxanthin in brain disorders

Ferdous,

Jansen,

Amjad

et al. 2024

J Nutr Sci

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Mitochondrial dysfunction is a common feature of brain disorders. Mitochondria play a central role in oxidative phosphorylation; thus changes in energy metabolism in the brain have been reported in conditions such as Alzheimer’s disease, Parkinson’s disease, and stroke. In addition, mitochondria regulate cellular responses associated with neuronal damage such as the production of reactive oxygen species (ROS), opening of the mitochondrial permeability transition pore (mPTP), and apoptosis. Therefore, interventions that aim to protect mitochondria may be effective against brain disorders. Fucoxanthin is a marine carotenoid that has recently gained recognition for its neuroprotective properties. However, the cellular mechanisms of fucoxanthin in brain disorders, particularly its role in mitochondrial function, have not been thoroughly discussed. This review summarises the current literature on the effects of fucoxanthin on oxidative stress, neuroinflammation, and apoptosis using in vitro and in vivo models of brain disorders. We further present the potential mechanisms by which fucoxanthin protects mitochondria, with the objective of developing dietary interventions for a spectrum of brain disorders. Although the studies reviewed are predominantly preclinical studies, they provide important insights into understanding the cellular and molecular functions of fucoxanthin in the brain. Future studies investigating the mechanisms of action and the molecular targets of fucoxanthin are warranted to develop translational approaches to brain disorders.

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Section: Mitochondrial Dysfunction In Brain Disordersmentioning

confidence: 99%

Section: Mitochondrial Dysfunction In Brain Disordersmentioning

confidence: 99%

Mitochondrial protective potential of fucoxanthin in brain disorders

Ferdous,

Jansen,

Amjad

et al. 2024

J Nutr Sci

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“…This mutation has been estimated to account for 1% of idiopathic PD cases and 4% of familial PD cases [66]. In addition, another mutation, that of DJ-1 related to the autosomal recessive inheritance of Parkinson's disease, has been identified [68]. Mutations in the DJ-1 gene have been linked to early-onset PD, slow disease progression, and a good response to l-DOPA [68].…”

Section: The Genetics Underlying Pdmentioning

confidence: 99%

“…In addition, another mutation, that of DJ-1 related to the autosomal recessive inheritance of Parkinson's disease, has been identified [68]. Mutations in the DJ-1 gene have been linked to early-onset PD, slow disease progression, and a good response to l-DOPA [68]. DJ-1 knockout in mice resulted in reduced survival and increased vulnerability to oxidative stress in both in vitro and in vivo models [68].…”

Section: The Genetics Underlying Pdmentioning

confidence: 99%

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The Use of a Novel Alpha-Synuclein Binding Aptamer in Models of Parkinson’s Disease

Ventura¹

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is because of her team's participation and assistance with the synthesis that any of these experiments could be conducted.I would like to thank my family, friends, members of the Department, and all of the colleagues I have had the pleasure of working with over the years. Without each and every one of you, I would not have had the emotional support, guidance, and/or expertise needed to complete this degree. I am also indebted to Dr. Hymie Anisman for his support and encouragement. Importantly, I would like to thank my supervisor, Dr. Matthew Holahan. Matt I am extremely grateful for your patience and support throughout the past decade, thank you.

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Targeted copy number variant identification across the neurodegenerative disease spectrum

Dilliott

Zhang

Wang

et al. 2022

Molec Gen & Gen Med

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Background Although genetic factors are known to contribute to neurodegenerative disease susceptibility, there remains a large amount of heritability unaccounted for across the diagnoses. Copy number variants (CNVs) contribute to these phenotypes, but their presence and influence on disease state remains relatively understudied. Methods Here, we applied a depth of coverage approach to detect CNVs in 80 genes previously associated with neurodegenerative disease within participants of the Ontario Neurodegenerative Disease Research Initiative ( n = 519). Results In total, we identified and validated four CNVs in the cohort, including: (1) a heterozygous deletion of exon 5 in OPTN in an Alzheimer's disease participant; (2) a duplication of exons 1–5 in PARK7 in an amyotrophic lateral sclerosis participant; (3) a duplication of >3 Mb, which encompassed ABCC6 , in a cerebrovascular disease (CVD) participant; and (4) a duplication of exons 7–11 in SAMHD1 in a mild cognitive impairment participant. We also identified 43 additional CNVs that may be candidates for future replication studies. Conclusion The identification of the CNVs suggests a portion of the apparent missing heritability of the phenotypes may be due to these structural variants, and their assessment is imperative for a thorough understanding of the genetic spectrum of neurodegeneration.

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Role of DJ-1 in parkinson’s disease

Cited by 31 publications

References 78 publications

Mitochondrial protective potential of fucoxanthin in brain disorders

Mitochondrial protective potential of fucoxanthin in brain disorders

The Use of a Novel Alpha-Synuclein Binding Aptamer in Models of Parkinson’s Disease

Targeted copy number variant identification across the neurodegenerative disease spectrum

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