Role of DNA methylation in human age prediction

Goel, Neelam; Karir, Priya; Garg, Vivek Kumar

doi:10.1016/j.mad.2017.08.012

Cited by 51 publications

(33 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Age has been associated with cancer-related markers ( 29 ) and we found that age was correlated inversely with TL ( r S = −0.21) and positively with DNA methylation of AHRR ( r S = 0.26 for average methylation of AHRR ; Supplementary Table 3 , available at Carcinogenesis Online).…”

Section: Resultsmentioning

confidence: 76%

DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 76%

DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Because a 10‐year difference may cause minor but measurable differences, it is recommended to match the comparison group by age. DNA methylation is a potential age‐biomarker or predictor; depending on the methods used the accuracy of age prediction is 5 years or less . Further, to reduce cost and because the number of subjects was low, pooling of sperm samples was performed.…”

Section: Does the Environment Influence Male Fertility And Sperm Charmentioning

confidence: 99%

Epigenetics as a Driver of Developmental Origins of Health and Disease: Did We Forget the Fathers?

Soubry

2017

BioEssays

View full text Add to dashboard Cite

What are the effects of our environment on human development and the next generation? Numerous studies have provided ample evidence that a healthy environment and lifestyle of the mother is important for her offspring. Biological mechanisms underlying these environmental influences have been proposed to involve alterations in the epigenome. Is there enough evidence to suggest a similar contribution from the part of the father? Animal models provide proof of a transgenerational epigenetic effect through the paternal germ line, but can this be translated to humans? To date, literature on fathers is scarce. Human studies do not always incorporate appropriate tools to evaluate paternal influences or epigenetic effects. In reviewing the literature, I stress the need to explore and recognize paternal contributions to offspring's health within the Developmental Origins of Health and Disease hypothesis, and coin this new concept the Paternal Origins of Health and Disease paradigm (POHaD). A better understanding of preconceptional origins of disease through the totality of paternal exposures, or the paternal exposome, will provide evidence-based public health recommendations for future fathers.

show abstract

“…12,13 It is shown that DNA methylation varies with development and environment, and it is involved in the development of various diseases. 14 Our previous studies have demonstrated that atherosclerosisrelated gene was involved in the development of PE. 15 The role of epigenetic modifications, particularly DNA methylation of the targeted gene in the trophoblastic cell apoptosis in PE, needs to be further studied.…”

Section: Introductionmentioning

confidence: 97%

Hypermethylation of endoplasmic reticulum disulfide oxidase 1α leads to trophoblast cell apoptosis through endoplasmic reticulum stress in preeclampsia

Xiong

Ding

Gao

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

Abnormal trophoblast cell apoptosis is implicated in the pathogenesis of pregnancy-related disorders including preeclampsia (PE), and endoplasmic reticulum (ER) stress has been considered as a novel pathway in the regulation of cell apoptosis. In this study, we observed that both apoptosis and ER stress are triggered in trophoblast cells under hypoxia as well as in the placenta of PE rats. Quantitative polymerase chain reaction and Western blot analysis showed that the expression of endoplasmic reticulum disulfide oxidase 1α (ERO1α) is suppressed in trophoblast cells under hypoxia due to the hypermethylation of the ERO1α promoter region, and the inhibition of ERO1α expression plays an important role in ER stress and trophoblast cell apoptosis. Furthermore, we found that DNA methyltransferase 1 (DNMT1) is a key methyltransferase for DNA methylation in the regulation of ERO1α expression, and the binding level of DNMT1 to the ERO1α promoter is markedly elevated under hypoxia although DNMT1 expression is inhibited by hypoxia, suggesting that the binding level of DNMT1 to the ERO1α promoter region rather than the DNMT1 expression level contributes to the hypermethylation of ERO1α. Taken together, these results demonstrate that the hypermethylation of ERO1α mediated by increased binding of DNMT1 to the ERO1α promoter leads to trophoblast cell apoptosis through ER stress in the placenta of PE rats, which shed insight into the etiology of PE and might present a validated therapeutic target for the treatment of PE.

show abstract

Role of DNA methylation in human age prediction

Cited by 51 publications

References 62 publications

DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons

DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons

Epigenetics as a Driver of Developmental Origins of Health and Disease: Did We Forget the Fathers?

Hypermethylation of endoplasmic reticulum disulfide oxidase 1α leads to trophoblast cell apoptosis through endoplasmic reticulum stress in preeclampsia

Contact Info

Product

Resources

About