Role of DNA repair processes in sister chromatid exchange frequency changes in peripheral blood lymphocytes during inflammatory diseases

Umnova, N V; Moskaleva, E. Yu.; Poroshenko, G. G.

doi:10.1007/bf00840816

Cited by 2 publications

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, Han et al (2018) found that dietary AST can reduce oxidative stress in Portunus trituberculatus (Han et al, 2018). Lymphocytes can secrete immune active substances, directly kill both bacteria‐infected cells and cancerous cells, and regulate the immune system (Umnova, Moskaleva, & Poroshenko, 1986). Many in vivo studies have demonstrated that astaxanthin can increase the immune response by enhancing lymphocyte content and function (Jagruthi et al, 2014; Wang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Amelioration of LPS‐induced inflammatory response and oxidative stress by astaxanthin in Channa argus lymphocyte via activating glucocorticoid receptor signalling pathways

Gao

et al. 2020

Aquac Res

View full text Add to dashboard Cite

The present study was conducted to evaluate the effects of astaxanthin (AST) against lipopolysaccharide (LPS)‐induced lymphocyte viability, ultrastructural lesions, apoptosis, oxidative stress and inflammatory responses in Channa argus. Lymphocytes exposed to more than 10 μg/ml LPS alone for 24 hr showed significantly decreased cell viability, elevated nitric oxide (NO) and malondialdehyde (MDA), lactate dehydrogenase (LDH) contents, and increased nuclear factor κB p65 (NF‐κB p65), myeloid differential protein‐88 (MyD88), tumour necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), interleukin‐8 (IL‐8), caspase‐3, caspase‐8 and caspase‐9 gene expression. LPS at a concentration of 10 μg/ml could induce oxidative stress and inflammatory responses in lymphocytes. The activities of antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)) were significantly decreased after exposure to 10 μg/ml LPS. Besides, AST strikingly antagonized the LPS‐induced negative effects. AST significantly increased the expression of HSP70, HSP90, IκB‐α, and glucocorticoid receptor (GR) and decreased inflammatory responses. Further study showed that AST can activate GR signalling pathway and inhibit p65 phosphorylation. In addition, AST attenuated LPS‐induced apoptosis, mitochondrial swelling, degeneration and vacuolization. Collectively, these findings suggest that AST has protective roles in LPS‐induced cell damage via modulating GR activation in C. argus lymphocytes.

show abstract

Section: Introductionmentioning

confidence: 99%

Amelioration of LPS‐induced inflammatory response and oxidative stress by astaxanthin in Channa argus lymphocyte via activating glucocorticoid receptor signalling pathways

Gao

et al. 2020

Aquac Res

View full text Add to dashboard Cite

show abstract

Effects of dietary Allium mongolicum Regel polysaccharide on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus

Zhu

Niu

et al. 2019

Mol Biol Rep

View full text Add to dashboard Cite

Role of DNA repair processes in sister chromatid exchange frequency changes in peripheral blood lymphocytes during inflammatory diseases

Cited by 2 publications

References 10 publications

Amelioration of LPS‐induced inflammatory response and oxidative stress by astaxanthin in Channa argus lymphocyte via activating glucocorticoid receptor signalling pathways

Amelioration of LPS‐induced inflammatory response and oxidative stress by astaxanthin in Channa argus lymphocyte via activating glucocorticoid receptor signalling pathways

Effects of dietary Allium mongolicum Regel polysaccharide on growth, lipopolysaccharide-induced antioxidant responses and immune responses in Channa argus

Contact Info

Product

Resources

About