Role of dysfunctional peri-organ adipose tissue in metabolic disease

Editorial: The impact of adipose tissue dysfunction on cardiovascular and renal disease, Volume II

“…Excess adipose tissue mass has been traditionally associated with metabolic dysfunction, but recent evidence suggests that adipose tissue quality and distribution are more critical for metabolic health than quantity ( 2 ). In addition to the well-known visceral and subcutaneous fat depots, other adipose tissues around blood vessels, such as perivascular, perirenal and epicardial fat, have emerged as novel contributors to CVD and CKD pathogenesis ( 3 – 5 ). These adipose tissues have unique features and dysfunctions in obesity and metabolic syndrome that may cause vascular and renal damage.…”