Role of Elastic Tissue in Cholesterol Deposition in the Arterial Wall

Jacotot, B.; Beaumont, J. L.; Monnier, Gilliane; Szigeti, M.; Bruno, Robert; Robert, L.

doi:10.1159/000175422

Cited by 41 publications

(6 citation statements)

References 12 publications

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“…We shall cite only two experimental findings to demonstrate the importance of elastin-lipid interactions in the aging of vascular wall and atherogenesis, in in vivo conditions also. The first experiment pertains to the in vivo uptake of ingested 14 C-cholesterol by the rat aorta and its elastin fibers (Szigeti et al 1972;Jacotot et al 1973). A tracer-dose of radioactive cholesterol was injected in rats fed either a normal diet or a diet containing 4% cholesterol.…”

Section: Lipid Fixation By Elastinmentioning

confidence: 99%

Rapid increase in human life expectancy: will it soon be limited by the aging of elastin?

Robert

Fülöp

2008

Biogerontology

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The postponement of the most frequent age-related diseases stimulated speculations of the possibility of "dying of old age". The selective decline of individual physiological functions-aging in spare-parts-indicates however the potential limitation of the life-span by the rapid decline of some of the vital parameters. We explored a possibility of such a limitation of maximal life-span by the age-related alteration of elastin, consisting in Ca-accumulation, lipid deposition and elastolytic degradation. The quantitative evaluation of these processes suggests an approximative upper limit for the elastic properties of the cardio-respiratory system of about 100-120 years, at least, as far as elastin is involved. This process, age-related alterations of elastic fibers, is however not the only one limiting the functional value of the cardiovascular system. Crosslinking of collagen fibers by advanced glycation end-products certainly contributes also to the age-dependent rigidification of the cardiovascular system. Therefore the answer to the initial question, can age-dependent alterations of a single matrix macromolecule be limiting such vital functions as the cardio-respiratory system-is a cautious yes, with however the caveat that other, independent mechanisms, such as the Maillard reaction, can also interfere with and limit further the functional value of such vital physiological functions.

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Section: Lipid Fixation By Elastinmentioning

confidence: 99%

Rapid increase in human life expectancy: will it soon be limited by the aging of elastin?

Robert

Fülöp

2008

Biogerontology

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“…For instance, human skin and cartilage collagens types I and II have half-lives of about 15 and 95 years, 309 while the half-lives of elastin fibers is equal to 304 or many times longer than average human life. 310,311 Therefore, in humans, ECM proteins are required to function for long years, during which time they are at risk of accumulating damage via glycation, 312 calcium and lipid accumulation, 313,314 and alterations of aspartic acid residues. 305,315 In turn these events have a profound effect on the mechanical properties of ECM proteins.…”

Section: Mechanisms and Physiology Of Agingmentioning

confidence: 99%

“…The utmost longevity of these biomolecules, relative to the intracellular proteins, exposes them to accumulated damage, which in turn affects their capability to provide mechanical properties and to manage tissue homeostasis. − Thus, at variance with the intracellular proteins, the half-lives of which are measured in hours or at most days, many ECM proteins exhibit half-lives measured in years. For instance, human skin and cartilage collagens types I and II have half-lives of about 15 and 95 years, while the half-lives of elastin fibers is equal to or many times longer than average human life. , Therefore, in humans, ECM proteins are required to function for long years, during which time they are at risk of accumulating damage via glycation, calcium and lipid accumulation, , and alterations of aspartic acid residues. , In turn these events have a profound effect on the mechanical properties of ECM proteins …”

Section: Mechanisms and Physiology Of Agingmentioning

confidence: 99%

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

Tenchov,

Sasso,

Wang

et al. 2023

ACS Chem. Neurosci.

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Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Many efforts have been put forth to understand and prevent the effects of aging. Thus, the major cellular and molecular hallmarks of aging have been identified, and their relationships to age-related diseases and malfunctions have been explored. Here, we use data from the CAS Content Collection to analyze the publication landscape of recent aging-related research. We review the advances in knowledge and delineate trends in research advancements on aging factors and attributes across time and geography. We also review the current concepts related to the major aging hallmarks on the molecular, cellular, and organismic level, ageassociated diseases, with attention to brain aging and brain health, as well as the major biochemical processes associated with aging. Major age-related diseases have been outlined, and their correlations with the major aging features and attributes are explored. We hope this review will be helpful for apprehending the current knowledge in the field of aging mechanisms and progression, in an effort to further solve the remaining challenges and fulfill its potential.

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“…Decreased distensibility in blood vessels correlates with increased tissue and serum lipids (Jacotot et al,, 1973;Newman et al, 1971;Band et al, 1973). Focal deposition of cholesterol, primary cholesterol esters, phospholipids and tryglycerides are causes of elastin fragmenta tion as well as early signs of atherosclerosis (Kramsch and Hollander, 1973;Adams and TuQan, 1961).…”

Section: Discussionmentioning

confidence: 99%

“…Increased lipid content in skin elastic fiber was demonstrated in aged and arteriosclerotic patients (Bouissou et al, 1973). In rat aorta and sponge tissue, the total amount of radioactive cholesterol incorporat ed into the insoluble fibrous fraction, containing structural glycopro teins and elastin, depended on the cholesterol content of the diet (Jacotot et al, 1973). Kramsch et al (1974) interpreted the accumulation of lipid at fragmented internal elastica as early manifestations of atheroclerosis.…”

Section: Elastinmentioning

confidence: 99%

Influence of dietary fat, meal pattern and length of feeding on cholesterol metabolism, cardiac stress-strain response and morphology in maturing male rats

Heng

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Role of Elastic Tissue in Cholesterol Deposition in the Arterial Wall

Cited by 41 publications

References 12 publications

Rapid increase in human life expectancy: will it soon be limited by the aging of elastin?

Rapid increase in human life expectancy: will it soon be limited by the aging of elastin?

Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement

Influence of dietary fat, meal pattern and length of feeding on cholesterol metabolism, cardiac stress-strain response and morphology in maturing male rats

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