Role of elevated plasma soluble ICAM-1 and bronchial lavage fluid IL-8 levels as markers of chronic lung disease in premature infants.

Abstract

Background -Pulmonary neutrophilia characterises both the relatively transient inflammation associated with infant

Early Activation of Inflammation and Clotting in the Preterm Lamb with Neonatal RDS: Comparison of Conventional Ventilation and High Frequency Oscillatory Ventilation

“…However, elastase in BALF probably better reflects inflammatory reaction in alveoli than the number of inflammatory cells itself (26). The finding of activated inflammation is in accordance with previous studies, which showed systemic activation of inflammation in RDS (1,5). A correlation between the severity of the inflammatory reaction (reflected by complement activation, decrease of PMN in the blood and release of ␤-glucuronidase) and the severity of protein leakage in the lungs was demonstrated in preterm rabbits (16).…”

Pulmonary inflammation and bronchopulmonary dysplasia

“…Increased concentrations of various cellular and endothelial adhesion molecules such as intercellular adhesion molecule (ICAM-1) and selectins have been detected in airway secretions and the circulation of preterm infants with BPD. [17][18][19] These data provide indirect evidence for the recruitment of circulating neutrophils into the airways and the pulmonary tissue. Most recently, a strong upregulation of ICAM-1 on endothelial cord cells and increased serum concentration of soluble ICAM-1 in preterm infants exposed to chorioamnionitis has been reported in preterm infants.…”

Neonatal Leukemoid Reaction and Early Development of Bronchopulmonary Dysplasia in a Very Low-Birth-Weight Infant

“…In addition, a few days after birth, chemoattractants (IL-8 and others), inflammatory cytokines (IL-6, IL·, Ilß, TNF-· and others) as well as other inflammatory mediators are significantly increased in airway specimens from infants subsequently developing bronchopulmonary dysplasia [14,15]. Furthermore, pulmonary neutrophilia characterizes both the relative inflammation associated with respiratory distress syndrome of prematurity and the inflammatory phase of bronchopulmonary dysplasia [16]. IL-8 levels in bronchial lavage fluid also correlated with neutrophil numbers, suggesting both recruitment and activation in response to the cytokine [16].…”