2010
DOI: 10.2174/1876386301003010029
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Role of Endocannabinoids in Neuron-Glial Crosstalk

Abstract: Evidence shows bidirectional crosstalk between neurons and glia, suggesting that glia play an active role in synaptic plasticity leading to chronic pain. Importantly, gliosis has been implicated in the development and maintenance of hyperalgesia or allodynia following chronic inflammation or nerve injury. Anandamide (AEA) and 2-arachidonoylglycerol (2-AG), or the lipoamino acid N-arachydonoyldopamine (NADA), are fatty acid derivative neurotransmitters, named endocannabinoids (eCBs). These perform several biolo… Show more

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Cited by 10 publications
(13 citation statements)
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“…Both astrocytes and microglia cells express enzymes involved in the synthesis and degradation of endocannabinoids [ 26 , 69 , 70 ], and produce cannabinoids such as anandamide [ 71 ], 2-AG [ 26 , 72 ] and palmitoylethanolamide [ 73 ]. Thus, endocannabinoids with glial origin can bind and activate neuronal cannabinoid receptors and thus contribute to the neuron-glia communication [ 74 , 75 ]. Although astrocytes in the adult mouse brain express cannabinoid receptors only at low levels [ 74 , 76 , 77 ], CB1 receptors were found to modulate important astrocyte functions [ 78 80 ].…”
Section: Discussionmentioning
confidence: 99%
“…Both astrocytes and microglia cells express enzymes involved in the synthesis and degradation of endocannabinoids [ 26 , 69 , 70 ], and produce cannabinoids such as anandamide [ 71 ], 2-AG [ 26 , 72 ] and palmitoylethanolamide [ 73 ]. Thus, endocannabinoids with glial origin can bind and activate neuronal cannabinoid receptors and thus contribute to the neuron-glia communication [ 74 , 75 ]. Although astrocytes in the adult mouse brain express cannabinoid receptors only at low levels [ 74 , 76 , 77 ], CB1 receptors were found to modulate important astrocyte functions [ 78 80 ].…”
Section: Discussionmentioning
confidence: 99%
“…In our model, we found a significantly increase of spinal CB1 receptor expression, while no changes have been detected for CB2R or KOR. The involvement of the CB2R, which is known to play an important role in chronic inflammatory process and also in reducing pain behaviour associated with neuropathic pain [13,[46][47][48] has been also object of this study. The co-administration of SA with AM630, the selective CB2 receptor antagonist, ruled out the contribute of this receptor in SA-mediated effects.…”
Section: Discussionmentioning
confidence: 99%
“…The possible involvement of the ECS in neuro-glia crosstalk was also discussed in the context of neuropathic pain [159] (see Section 2.2). Glial cells and neuron-glia communication were implicated in the development of pain sensation after neutral stimuli (allodynia) and hypersensitivity (hyperalgesia).…”
Section: Cb2rs In Neuron-microglia Interactionmentioning
confidence: 99%