Role of endogenous insulin in pancreatic secretion in rats

Iwabe, Chika; Shiratori, Keiko; Shimizu, Kyoko; Hayashi, Naoaki

doi:10.1159/000055828

Cited by 10 publications

(2 citation statements)

References 38 publications

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“…Pancreatic β cells account for only 1–5% of the pancreatic capacity, most of which is occupied by exocrine pancreatic tissue . However, studies in both humans with diabetes and animals given β cell toxins indicate that insulin is necessary for normal acinar cell function . On the other hand, some studies have demonstrated that PV is positively associated with β cell function as evaluated by the insulinogenic index and the homeostasis model assessment of β cell function (HOMA‐β) in type 2 DM .…”

Section: Discussionmentioning

confidence: 99%

Pancreatic volume is reduced in patients with latent autoimmune diabetes in adults

Lü

Hou

Pang

et al. 2016

Diabetes Metabolism Res

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Aims This study aimed to compare pancreatic volume and its clinical significance among patients with type 2 diabetes mellitus (DM), adult-onset type 1 DM and latent autoimmune diabetes in adults (LADA).Methods This is a cross-sectional study. One hundred twenty-six outpatients (68 with LADA and 58 with type 1 DM) and 158 inpatients (71 with type 2 DM and 87 non-diabetic controls) were recruited during May-July 2013 in Shanghai Jiao Tong University Affiliated Sixth People's Hospital. All the patients underwent abdominal computerized tomography; pancreatic volume was then calculated.Results The mean pancreatic volume was highest in the controls, followed by those in patients with type 2 DM, LADA and type 1 DM. The pancreatic volume in LADA was comparable with that in type 2 DM but significantly greater than that in type 1 DM (p < 0.05). The pancreatic volume in patients with LADA was significantly correlated with sex, waist circumference, body surface area, body mass index, diastolic blood pressure and high-density lipoprotein cholesterol (all p < 0.05). The correlation between pancreatic volume and fasting C-peptide was high in patients with LADA (r = 0.643, p < 0.001) and moderate in patients with type 2 DM (r = 0.467, p < 0.001). The area under the receiver operating characteristic curve for pancreatic volume predictive of absolute insulin deficiency (FCP < 0.9 ng/mL) was 0.85 (0.76-0.94) in LADA.Conclusions Pancreatic atrophy in LADA was less marked than in type 1 DM. Pancreatic atrophy may suggest reduced level of fasting C-peptide in patients with LADA.

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Section: Discussionmentioning

confidence: 99%

Pancreatic volume is reduced in patients with latent autoimmune diabetes in adults

Lü

Hou

Pang

et al. 2016

Diabetes Metabolism Res

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“…In whole animal studies, 2DG is used to induce the release of endogenous insulin via a vagal cholinergic pathway (Karlsson et al, 1987), which in turn intensifies the secretion of pancreatic juice in anaesthetised rats (Iwabe et al, 2001). Carlson et al (1999) showed that vagal mechanisms indeed play a crucial role in insulin release but are also responsible for controlling pancreatic islet blood flow.…”

Section: Discussionmentioning

confidence: 99%

The effect of exogenous leptin on pancreatic enzyme secretion in anaesthetized rats

Matyjek

Woliński²,

Laubitz³

et al. 2005

J. Anim. Feed Sci.

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The influence of leptin on the secretion of pancreatic juice was examined in biliary-pancreatic duct-cannulated anaesthetised rats. Exogenous leptin was given in boluses either intravenously or intraduodenally. A low dose of leptin (0.1 μg/kg BW) had no effect on pancreatic secretion. Leptin in a dose of 1 μg/kg BW given intravenously inhibited protein and amylase output only when the exocrine pancreas was stimulated by CCK-8 (12 pmol/kg BW, iv). Leptin in a high, pharmacological dose (10 μg/kg BW) given intravenously inhibited juice secretion, protein and amylase output, whereas given intraduodenally, stimulated them. Intravenous infusion of 2-deoxy-glucose (0.25 g/kg BW per h) induced pancreatic juice secretion, which was abolished by a leptin bolus (10 μg/kg BW). In conclusion, leptin can regulate the exocrine pancreas via different mechanisms.

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Insulo–Acinar Relationship

Shiratori

Shimizu

2018

The Pancreas

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Role of endogenous insulin in pancreatic secretion in rats

Cited by 10 publications

References 38 publications

Pancreatic volume is reduced in patients with latent autoimmune diabetes in adults

Pancreatic volume is reduced in patients with latent autoimmune diabetes in adults

The effect of exogenous leptin on pancreatic enzyme secretion in anaesthetized rats

Insulo–Acinar Relationship

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