Role of endogenous zinc in bones of newborn rats

Drzazga, Z.; Michalik, Katarzyna; Maciejewska, Karina; Trzeciak, Hanna; Kaszuba, Michał

doi:10.1002/biof.5520300405

Cited by 11 publications

(13 citation statements)

References 9 publications

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“…7b) confirms the substantial role of Zn mainly at the beginning of bone ontogenesis. These results are compatible to the results obtained for mandibles (28), although quantitative comparison of element concentration indicates that the content of Ca and Zn is a little lower in the femur than in the mandible.…”

Section: Resultssupporting

confidence: 91%

Optical and X‐ray Fluorescence Spectroscopy Studies of Bone and Teeth in Newborn Rats After Maternal Treatment with Indinavir

Drzazga

Michalik

Maciejewska

et al. 2010

Photochem & Photobiology

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An experiment estimating influence of antiviral drug indinavir treatment during pregnancy on bones and teeth development in newborn rats was performed. Two different fluorescence noninvasive spectroscopy techniques, i.e. laser (407 nm)-induced fluorescence method to characterize the organic fluorescent molecules and X-ray fluorescence analysis to determine mineral components were used to study the surface response of femur, mandible and incisor during their formation in the first month of a rat's life. Differences in autofluorescence depending on the form of the bone were observed on the basis of the emission from enamel in 7-, 14- and 28-day-old newborn rats. The dependence between decrease in intensity of fluorescence and increase in mineralization with age in newborn rats was observed. An enhancement of the autofluorescence and a decrease in the concentration of Ca as a main element, as well as disturbances in the concentration of Zn as trace element were observed for bone as well as teeth in newborns during the first month of their life after maternal administration of indinavir (500 mg kg(-1) p.o.) in comparison with the control group. The results indicate that indinavir causes a delay in development of the skeleton and teeth in newborn rats.

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Section: Resultssupporting

confidence: 91%

Optical and X‐ray Fluorescence Spectroscopy Studies of Bone and Teeth in Newborn Rats After Maternal Treatment with Indinavir

Drzazga

Michalik

Maciejewska

et al. 2010

Photochem & Photobiology

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“…In our previous studies, concentration of Ca with age of rats changed differently in various types of bones. In skulls and femurs Ca content decreased slightly, in mandibles it increased a little, while in tibiae there were no visible changes . These results did not show continuous increase of Ca content with age, as was expected, in spite of the fact that they were conducted in newborns.…”

Section: Discussionsupporting

confidence: 47%

“…Quantitative analysis using FP method let the concentrations of elements present in studied material to be obtained: Ca, Mn, Fe, Cu, Zn, As, Se, Sr, Cd, Pb. Content of abundant element Ca was reported earlier [36]. We made an attempt to measure P signal, however it could be analyzed only qualitatively, because this element has characteristic energy, for which used detector has a weak efficiency (below 30%) and quantitative data would not be reliable enough.…”

Section: Resultsmentioning

confidence: 99%

Role of trace elements (Zn, Sr, Fe) in bone development: Energy dispersive X‐ray fluorescence study of rat bone and tooth tissue

Maciejewska

Drzazga

Kaszuba³

2014

BioFactors

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Osteoporosis is one of the most common debilitating disease around the world and it is more and more established among young people. There are well known recommendations for nutrition of newborns and children concerning adequate calcium and vitamin D intake in order to maintain proper bone density. Nevertheless, important role in structure and function of a healthy bone tissue is played by an integration between all constituents including elements other than Ca, like trace elements, which control vital processes in bone tissue. It is important from scientific point of view as well as prevention of bone diseases, to monitor the mineralization process considering changes of the concentration of minerals during first stage of bone formation. This work presents studies of trace element (zinc, strontium, and iron) concentration in bones and teeth of Wistar rats at the age of 7, 14, and 28 days. Energy dispersive X-ray fluorescence (EDXRF) was used to examine mandibles, skulls, femurs, tibiae, and incisors. The quantitative analysis was performed using fundamental parameters method (FP). Zn and Sr concentrations were highest for the youngest individuals and decreased with age of rats, while Fe content was stable in bone matrix for most studied bones. Our results reveal the necessity of monitoring concentration of not only major, but also minor elements, because the trace elements play special role in the first period of bone development.

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“…Zinc is the composition of bone, also involved in bone metabolism. As an activator of lots of metal enzymes, zinc can induce activities of bone metabolic enzymes, such as alkaline phosphatase, collagenase, and sulfuricoylase, and also influence the levels of 1,25-OH vitamin D3 and calcitonin [37,38]. Zinc deficiency has been shown to reduce osteoblastic activity, collagen and proteoglycan synthesis, and alkaline phosphatase activity, as well as to retard growth and cause bone fragility and bone deposition of calcium and magnesium [39,40].…”

Section: Discussionmentioning

confidence: 98%

Correlation Analysis Between Bone Mineral Density and Serum Element Contents of Postmenopausal Women in Xi’an Urban Area

Liu

Zhang

et al. 2009

Biol Trace Elem Res

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The objective of this paper is to investigate the correlation between serum macro-element and trace element contents and bone mineral density (BMD) as well as the occurrence of osteoporosis. After the epidemiological investigation of 290 postmenopausal women from ages 45 to 65 in the Xi'an urban area, their blood was collected and serum concentrations of macro-elements, calcium, phosphonium, potassium, sodium, magnesium, and trace elements, zinc, iron, copper, and selenium were determined using atomic absorption spectrometry. Their BMD was measured by QDR-2000 dual-energy X-ray absorptiometry (DEXA). The correlation analysis between BMD and serum element contents was done with the software of SPSS 13.0. The correlation analysis of serum elements of postmenopausal women showed that there was a significant correlation between serum calcium and the other elements, and also a significant correlation between serum phosphonium and the others except serum potassium. The serum potassium content had a significant correlation with serum calcium, sodium and iron, but sodium content showed a significant correlation with the others except iron and selenium. In addition, copper had a significant correlation with the others except potassium and selenium. In correlation analysis between BMD and the elements contents, only did the potassium content show a significant positive correlation with BMD of lumbar vertebra and proximal femora. The comparison results between osteoporosis group, osteopenia group, and healthy group showed that there was no significant difference in the element contents between the groups, but there existed a tendency that potassium content increased with the rise of BMD. There exist significant correlations between the contents of serum elements such as calcium, phosphonium, sodium, potassium, magnesium, zinc, iron, copper, and selenium, but no significant differences in these elements contents between the osteoporosis group, osteopenia group, and healthy group. Serum potassium content shows a significant positive correlation with BMD, suggesting potassium may be involved in the development of osteoporosis in postmenopausal women.

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Role of endogenous zinc in bones of newborn rats

Cited by 11 publications

References 9 publications

Optical and X‐ray Fluorescence Spectroscopy Studies of Bone and Teeth in Newborn Rats After Maternal Treatment with Indinavir

Optical and X‐ray Fluorescence Spectroscopy Studies of Bone and Teeth in Newborn Rats After Maternal Treatment with Indinavir

Role of trace elements (Zn, Sr, Fe) in bone development: Energy dispersive X‐ray fluorescence study of rat bone and tooth tissue

Correlation Analysis Between Bone Mineral Density and Serum Element Contents of Postmenopausal Women in Xi’an Urban Area

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