Role of trace elements (Zn, Sr, Fe) in bone development: Energy dispersive X‐ray fluorescence study of rat bone and tooth tissue

Abstract

Osteoporosis is one of the most common debilitating disease around the world and it is more and more established among young people. There are well known recommendations for nutrition of newborns and children concerning adequate calcium and vitamin D intake in order to maintain proper bone density. Nevertheless, important role in structure and function of a healthy bone tissue is played by an integration between all constituents including elements other than Ca, like trace elements, which control vital processes in bone tissue. It is important from scientific point of view as well as prevention of bone diseases, to monitor the mineralization process considering changes of the concentration of minerals during first stage of bone formation. This work presents studies of trace element (zinc, strontium, and iron) concentration in bones and teeth of Wistar rats at the age of 7, 14, and 28 days. Energy dispersive X-ray fluorescence (EDXRF) was used to examine mandibles, skulls, femurs, tibiae, and incisors. The quantitative analysis was performed using fundamental parameters method (FP). Zn and Sr concentrations were highest for the youngest individuals and decreased with age of rats, while Fe content was stable in bone matrix for most studied bones. Our results reveal the necessity of monitoring concentration of not only major, but also minor elements, because the trace elements play special role in the first period of bone development.

The changes in bone organic and inorganic matrix in newborn rats after maternal application of antiretroviral agents: Indinavir and zidovudine

“…Figure presents calcium concentration in chosen, representative types of bones. Ca content in normal, healthy bones changed with age differently in different types of bones, what was reported earlier . The character of change in the drug groups was mostly the same, but the values were different than in controls in some cases.…”

Urinary heavy metals, phthalates, phenols, thiocyanate, parabens, pesticides, polyaromatic hydrocarbons but not arsenic or polyfluorinated compounds are associated with adult oral health: USA NHANES, 2011–2012

“…Moreover, the only paraben element associated with bone loss around the mouth is only borderline. More studies would be needed to confirm or refute these findings in the present study and to compare with previous research as well (Maciejewska et al 2014). The link between PAHs and oral health including the aching has not ben firmly established, although the toxicology of PAHs was previously described in numerous human diseases already (Tormoehlen et al 2014).…”

The Distribution of Essential, Trace, and Nonessential Minerals in Weanling Male Rats Fed Sheep or Cow Milk

“…Minerals are key to maintaining the metabolic function of several biochemical pathways including maintaining protein structure, facilitating enzymatic reactions, and transporting nutrients . Individuals obtain the required minerals through a balanced diet .…”

“…Minerals are key to maintaining the metabolic function of several biochemical pathways including maintaining protein structure, facilitating enzymatic reactions, and transporting nutrients. [1][2][3] Individuals obtain the required minerals through a balanced diet. [4] Complex interactions that occur between minerals within the digestive system can cause positive or negative effects on the absorption and subsequent distribution of minerals within the body.…”