Role of endoplasmic reticulum stress-related unfolded protein response and its implications in dengue virus infection for biomarker development

Das, Biswadeep; Samal, Sagnika; Hamdi, Hamida; Pal, Aditi; Biswas, Arpita; Behera, Jyotika; Singh, Gurdip; Behera, Chinmay Kumar; Sahoo, Debee Prasad

doi:10.1016/j.lfs.2023.121982

Cited by 9 publications

(1 citation statement)

References 76 publications

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“…This stress response disrupts the process of lipogenesis and exacerbates the accumulation of fat in the liver, resulting in a vicious cycle that drives the advancement of fatty liver disease toward more severe conditions like hepatitis, hepatic fibrosis, and even hepatic cirrhosis. The unfolded protein response is activated as a response to ER stress, serving as a protective mechanism for the liver during the early phase (Das et al., 2023 ). However, as the stress persists, UPR can intensify inflammatory responses, leading to the promotion of hepatocyte apoptosis.…”

Section: Disease-associated With Er and Mitochondria Dysfunctionmentioning

confidence: 99%

Intricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum

Girigoswami,

Pallavi,

Girigoswami

2023

Drug Delivery

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It is evident that site-specific systemic drug delivery can reduce side effects, systemic toxicity, and minimal dosage requirements predominantly by delivering drugs to particular pathological sites, cells, and even subcellular structures. The endoplasmic reticulum (ER) and associated cell organelles play a vital role in several essential cellular functions and activities, such as the synthesis of lipids, steroids, membrane-associated proteins along with intracellular transport, signaling of Ca 2+ , and specific response to stress. Therefore, the dysfunction of ER is correlated with numerous diseases where cancer, neurodegenerative disorders, diabetes mellitus, hepatic disorder, etc., are very common. To achieve satisfactory therapeutic results in certain diseases, it is essential to engineer delivery systems that can effectively enter the cells and target ER. Nanoparticles are highly biocompatible, contain a variety of cargos or payloads, and can be modified in a pliable manner to achieve therapeutic effectiveness at the subcellular level when delivered to specific organelles. Passive targeting drug delivery vehicles, or active targeting drug delivery systems, reduce the nonselective accumulation of drugs while reducing side effects by modifying them with small molecular compounds, antibodies, polypeptides, or isolated bio-membranes. The targeting of ER and closely associated organelles in cells using nanoparticles, however, is still unsymmetrically understood. Therefore, here we summarized the pathophysiological prospect of ER stress, involvement of ER and mitochondrial response, disease related to ER dysfunctions, essential therapeutics, and nanoenabled modulation of their delivery to optimize therapy.

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Section: Disease-associated With Er and Mitochondria Dysfunctionmentioning

confidence: 99%