Role of epigenetic alterations in aflatoxin‐induced hepatocellular carcinoma

Mungamuri, Sathish Kumar; Mavuduru, Vijay Aditya

doi:10.1002/lci2.20

Cited by 16 publications

(12 citation statements)

References 133 publications

(306 reference statements)

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“…Studies have found the risk of HCC increased when the exposure to aflatoxin occurred in the presence of HBV infection, and a continuous and higher level of aflatoxin exposure could lead to cancer progression. 31,32 However, refrigerators and refrigeration equipment are widely used in China now, which can effectively inhibit the production of aflatoxin in food. Workers chronically exposed to toxic chemical agents could have increased risk of HCC development and these toxic chemical agents had a positive synergistic effect with hepatitis virus infection on liver damage.…”

Section: Discussionmentioning

confidence: 99%

“…Occupational toxic exposure, drug intake and food contaminated by aflatoxin are defined factors associated with HCC development. Studies have found the risk of HCC increased when the exposure to aflatoxin occurred in the presence of HBV infection, and a continuous and higher level of aflatoxin exposure could lead to cancer progression 31,32 . However, refrigerators and refrigeration equipment are widely used in China now, which can effectively inhibit the production of aflatoxin in food.…”

Section: Discussionmentioning

confidence: 99%

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Association between hepatitis B and E virus infection and hepatocellular carcinoma risk

Meng

Lin

et al. 2021

Intl Journal of Cancer

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The role of hepatitis E virus (HEV) in developing hepatocellular carcinoma (HCC) is unclear. Our study aimed to investigate the role of HE infection in HCC development and the effect of hepatitis B virus (HBV) and HEV coinfection on HCC risk. A hospital-based case-control study was conducted. A total of 474 eligible HCC cases and 586 control patients were successfully recruited. The fasting venous blood was collected from the patients at the first visited to hospital and HBV infection and HEV infection were examined within 5 days. Crude and adjusted odd ratios (ORs) with 95% confidence interval (95% CI) were estimated by using logistic regression model. HBV infection (OR: 63.10, 95% CI: 42.02-97.26) rather than HEV infection (OR: 1.08, 95% CI: 0.721-1.65) was associated with an increased risk of HCC after adjustment for confounders. The association between HBV infection and HCC risk was more

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between hepatitis B and E virus infection and hepatocellular carcinoma risk

Meng

Lin

et al. 2021

Intl Journal of Cancer

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“…AFs mainly target the liver, causing hepatocellular damage [9]. It was reported that AFB1 which is formed after being metabolized, causes damage to DNA and different cellular proteins through its toxic metabolites such as AFB1-8,9 epoxide (AFBO) [10,11], and disrupts protein and lipid metabolism by stimulating the production of reactive oxygen species (ROS) [12]. It is unclear whether AFB1 directly stimulates lipid peroxidation through increased ROS synthesis or the increased sensitivity of tissue to peroxidation results from impaired antioxidant defense, but both mechanisms are probably involved [13] AFB1 is involved in antioxidant enzyme activity (GSH, SOD and CAT etc.)…”

Section: Introductionmentioning

confidence: 99%

The effect of curcumin on some cytokines, antioxidants and liver function tests in rats induced by Aflatoxin B1

Hatipoğlu

Keskin

2022

Heliyon

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“…According to scientific reports, nearly 25% of global food supplies are contaminated with AFs, making them a serious issue of concern for world nations' health ( 12 ). AFs are health hazardous environmental risk factors in the onset of liver cancer, kidney failure, and gastrointestinal problems ( 13 ), in turn, their health consequences depend on duration of exposure and enzymatic/genetic alterations in target organs ( 14 ).…”

Section: Prologuementioning

confidence: 99%

May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects

2022

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The future GCC-connected environmental risk factors expedited the progression of nCDs. Indeed, the emergence of AFs is becoming a global food security concern. AFs are lethal carcinogenic mycotoxins, causing damage to the liver, kidney, and gastrointestinal organs. Long-term exposure to AFs leads to liver cancer. Almost a variety of food commodities, crops, spices, herbaceous materials, nuts, and processed foods can be contaminated with AFs. In this regard, the primary sections of this review aim to cover influencing factors in the occurrence of AFs, the role of AFs in progression of nCDs, links between GCC/nCDs and exposure to AFs, frequency of AFs-based academic investigations, and world distribution of AFs. Next, the current trends in the application of PPs to alleviate AFs toxicity are discussed. Nearly, more than 20,000 published records indexed in scientific databases have been screened to find recent trends on AFs and application of PPs in AFs therapy. Accordingly, shifts in world climate, improper infrastructures for production/storage of food commodities, inconsistency of global polices on AFs permissible concentration in food/feed, and lack of the public awareness are accounting for a considerable proportion of AFs damages. AFs exhibited their toxic effects by triggering the progression of inflammation and oxidative/nitrosative stress, in turn, leading to the onset of nCDs. PPs could decrease AFs-associated oxidative stress, genotoxic, mutagenic, and carcinogenic effects by improving cellular antioxidant balance, regulation of signaling pathways, alleviating inflammatory responses, and modification of gene expression profile in a dose/time-reliant fashion. The administration of PPs alone displayed lower biological properties compared to co-treatment of these metabolites with AFs. This issue might highlight the therapeutic application of PPs than their preventative content. Flavonoids such as quercetin and oxidized tea phenolics, curcumin and resveratrol were the most studied anti-AFs PPs. Our literature review clearly disclosed that considering PPs in antioxidant therapies to alleviate complications of AFs requires improvement in their bioavailability, pharmacokinetics, tissue clearance, and off-target mode of action. Due to the emergencies in the elimination of AFs in food/feedstuffs, further large-scale clinical assessment of PPs to decrease the consequences of AFs is highly required.

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Role of epigenetic alterations in aflatoxin‐induced hepatocellular carcinoma

Cited by 16 publications

References 133 publications

Association between hepatitis B and E virus infection and hepatocellular carcinoma risk

Association between hepatitis B and E virus infection and hepatocellular carcinoma risk

The effect of curcumin on some cytokines, antioxidants and liver function tests in rats induced by Aflatoxin B1

May phytophenolics alleviate aflatoxins-induced health challenges? A holistic insight on current landscape and future prospects

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