Role of epstein‐barr virus in the severity of recurrent respiratory papillomatosis

Costa, Victor; El‐Achkar, Vivian Narana Ribeiro; Barros, Patrícia Pimentel de; León, Jorge Esquiche; Ribeiro‐Silva, Alfredo; Carlos, Román; Pignatari, Shirley Shizue Nagata; Ferreira, Silvaneide; Mello, Bárbara Piffero; Sichero, Laura; Villa, Luisa L.; Kaminagakura, Estela

doi:10.1002/lary.28465

Cited by 8 publications

(7 citation statements)

References 45 publications

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“…Among these patients, we previously reported that JORRPs were significantly more aggressive (mean Derkay score of 10.9) than AORRP cases (mean Derkay score of 8.2; p = .02), 24 and that the presence of Epstein-Barr was not associated to progression/severity of RRP. 25 Molecular variants of HPVs 6 and 11 were here characterized based on the nucleotide sequence of segments of the viral genome that enclose sufficient single nucleotide polymorphisms to discriminate between major viral lineages and sublineages. 14,15 We observed predominance of HPV-6 B1 and B3 variants with some nonsignificant differences in their distribution: specifically, HPV-6 B1 variants were detected in higher frequency among JORRP cases.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus 6 and 11 variants in recurrent respiratory papillomatosis

Sichero

Ferreira

López

et al. 2020

Journal of Medical Virology

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Human papillomavirus (HPV) types 6 and 11 are the etiological agents of recurrent respiratory papillomatosis (RRP). We examined the prevalence and distribution of HPVs 6 and 11 genetic variants in juvenile onset (JORRP) and adult onset (AORRP) laryngeal papillomas. Cases of JORRP and AORRP were collected, retrospectively. HPV detection and genotyping were accessed by polymerase chain reaction‐sequencing in 67 RRP samples. Overall, the most prevalent HPV‐6 variants were from B1 (55.8%) and B3 (27.9%) sublineages, whereas among HPV‐11 positive samples A2 (62.5%) variants were predominant. A higher prevalence of HPV‐6 B1 was observed in JORRP (83.3% B1 and 16.7% B3), compared with AORRP cases (58.3% B1 and 41.7% B3). HPV‐11 A2 variants were more prevalent both in JORRP (57.2%) and in AORRP cases (70.0%). Nevertheless, with the exception that HPV‐6 B1 were significantly less likely to recur, there was a lack of association between any particular HPVs 6 or 11 variant and clinicopathological features. Our data do not support an association between HPVs 6 and 11 variability and RRP.

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Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus 6 and 11 variants in recurrent respiratory papillomatosis

Sichero

Ferreira

López

et al. 2020

Journal of Medical Virology

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“…Age at onset was the only significant risk factor for aggressive disease in JO-RRP, whereas in adults, both HPV11 and observation time ≥10 years were significant [ 64 ]. In a series by Costa et al (2019), 36 patients with JO-RRP and 44 patients AO-RRP were subdivided into low- and high-risk groups based on Derkay scores [ 71 ]. HPV6 detection was significantly higher in AO-RRP cases ( p = 0.03), whereas HPV11 was more prevalent in JO-RRP cases ( p = 0.02), and even more prevalent in high-risk JO-RRP cases (Derkay laryngoscopic scale ≥ 20) ( p = 0.04) [ 71 ].…”

Section: Laryngeal Squamous Cell Papillomas (Rrp)mentioning

confidence: 99%

“…In a series by Costa et al (2019), 36 patients with JO-RRP and 44 patients AO-RRP were subdivided into low- and high-risk groups based on Derkay scores [ 71 ]. HPV6 detection was significantly higher in AO-RRP cases ( p = 0.03), whereas HPV11 was more prevalent in JO-RRP cases ( p = 0.02), and even more prevalent in high-risk JO-RRP cases (Derkay laryngoscopic scale ≥ 20) ( p = 0.04) [ 71 ]. Similar results were published by Nogueira et al (2021), who found that age of onset of RRP had an important impact on the number of surgeries needed to control the disease.…”

Section: Laryngeal Squamous Cell Papillomas (Rrp)mentioning

confidence: 99%

HPV-Associated Benign Squamous Cell Papillomas in the Upper Aero-Digestive Tract and Their Malignant Potential

Syrjänen

2021

Viruses

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Squamous cell papilloma (SCP) in the upper aero-digestive tract is a rare disease entity with bimodal age presentation both at childhood and in adults. It originates from stratified squamous and/or respiratory epithelium. Traditionally, SCPs have been linked to chemical or mechanical irritation but, since the 1980s, they have also been associated with human papillomavirus (HPV) infection. Approximately 30% of the head and neck SCPs are associated with HPV infection, with this association being highest for laryngeal papillomas (76–94%), followed by oral (27–48%), sinonasal (25–40%), and oropharyngeal papillomas (6–7%). There is, however, a wide variation in HPV prevalence, the highest being in esophageal SCPs (11–57%). HPV6 and HPV11 are the two main HPV genotypes present, but these are also high-risk HPVs as they are infrequently detected. Some 20% of the oral and oropharyngeal papillomas also contain cutaneous HPV genotypes. Despite their benign morphology, some SCPs tend to recur and even undergo malignant transformation. The highest malignant potential is associated with sinonasal inverted papillomas (7–11%). This review discusses the evidence regarding HPV etiology of benign SCPs in the upper aero-digestive tract and their HPV-related malignant transformation. In addition, studies on HPV exposure at an early age are discussed, as are the animal models shedding light on HPV transmission, viral latency, and its reactivation.

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“…Juvenile onset recurrent respiratory papillomatosis (JoRRP) is a rare and challenging HPV-induced disease, frequently associated with mucosal HPV-type infection, in particular HPV 6 and 11, and characterised by the growth of squamous papillomata in the airway epithelium [ 1 ]. It is defined by the onset before 12 years of age with the peak of incidence being commonly before 5 years [ 2 ]. Because of JoRRP’s typical recurrence, patients often require multiple surgical debulking procedures to maintain an airway patency [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis

Bertinazzi

Gheit

Polesel

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose The aim of our study was to evaluate the prevalence of different HPV genera—alpha, beta and gamma—in Juvenile onset Recurrent Respiratory Papillomatosis (JoRRP) and examine the association of type and genus-specific viral features with the clinical outcome of disease. Methods This retrospective observational study included consecutive patients with JoRRP who were treated in a referral centre between October 2000 and October 2020. All patients underwent cold excision and laser vaporisation of papillomatous lesions. Samples were analysed for the presence of 120 viral genotypes (22 alpha-HPV, 46 beta-HPV, 52 gamma-HPV) using a highly sensitive multiplex genotyping assay. Results Twenty patients with JoRRP, aged 0.3–11 years, were included, with a median follow-up of 13.5 years. All samples were HPV DNA positive: 20 (100%) for alpha-HPV DNA; 7 (35%) for beta—HPV DNA; 0 for gamma-HPV DNA. Three groups were defined according to the number of infections: seven cases (35%) with HPV mono-infection; ten cases (50%) with HPV double-infection; three cases (15%) with ≥ 3 HPV infections. At diagnosis, patients with ≥ 3 HPV infections reported higher median Derkay’s score than those with mono-infection (21 vs 14, P = 0.018). Number of HPV infections was also associated with clinical outcomes, with an average of 0.5 surgical procedures/year in patients with mono-infection, 1.2 for double-infection, 2.6 for ≥ 3 infections (P = 0.006). Conclusion Despite the small sample size, these preliminary data support an association between the number of different alpha and beta HPV co-infections and the clinical severity of the disease.

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Role of epstein‐barr virus in the severity of recurrent respiratory papillomatosis

Cited by 8 publications

References 45 publications

Prevalence of human papillomavirus 6 and 11 variants in recurrent respiratory papillomatosis

Prevalence of human papillomavirus 6 and 11 variants in recurrent respiratory papillomatosis

HPV-Associated Benign Squamous Cell Papillomas in the Upper Aero-Digestive Tract and Their Malignant Potential

Clinical implications of alpha, beta, and gamma HPV infection in juvenile onset recurrent respiratory papillomatosis

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