Role of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography in gastrointestinal cancers

Gauthé, Mathieu; Richard-Molard, Marion; Cacheux, Wulfran; Michel, Pierre; Jouve, Jean-Louis; Mitry, Emmanuel; Alberini, Jean-Louis; Lièvre, Astrid

doi:10.1016/j.dld.2015.02.005

Cited by 31 publications

(24 citation statements)

References 177 publications

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“…Due to relatively low spatial resolution, FDG PET-CT does not add to assessment of primary tumour (T) stage [24]. For the assessment of locoregional lymph nodal staging in gastric cancer, FDG PET-CT is more specific but less sensitive than CT alone [25][26][27]. However, recent studies have shown poorer prognosis for patients with FDG-avid nodes [11,28,29], suggesting an additional role for PET-CT in identifying patients at higher risk of metastasis.…”

Section: Introductionmentioning

confidence: 99%

Staging FDG PET-CT changes management in patients with gastric adenocarcinoma who are eligible for radical treatment

Bosch

Chicklore

Cook

et al. 2019

Eur J Nucl Med Mol Imaging

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Aim 18-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET-CT) is valuable in the management of patients with oesophageal cancer, but a role in gastric cancer staging is debated. Our aim was to review the role of FDG PET-CT in a large gastric cancer cohort in a tertiary UK centre. Methods We retrospectively reviewed data from 330 patients presenting with gastric adenocarcinoma between March 2014 and December 2016 of whom 105 underwent pre-treatment staging FDG PET-CT scans. FDG PET-CT scans were graded qualitatively and quantitatively (SUV max) and compared with staging diagnostic CT and operative pathology results (n = 30) in those undergoing resection. Results Of the 105 patients (74 M, median age 73 years) 86% of primary tumours were metabolically active (uptake greater than normal stomach) on FDG PET-CT [41/44 (93%) of the intestinal histological subtype (SUV max 14.1 ± 1.3) compared to 36/46 (78%) of non-intestinal types (SUV max 9.0 ± 0.9), p = 0.005]. FDG PET-CT upstaged nodal or metastastic staging of 20 patients (19%; 13 intestinal, 6 non-intestinal, 1 not reported), with 17 showing distant metastases not evident on other imaging. On histological analysis, available in 30 patients, FDG PET-CT showed low sensitivity (40%) but higher specificity (73%) for nodal involvement. Conclusion FDG PET-CT provides new information in a clinically useful proportion of patients, which leads to changes in treatment strategy, most frequently by detecting previously unidentified metastases, particularly in those with intestinal-type tumours.

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Section: Introductionmentioning

confidence: 99%

Staging FDG PET-CT changes management in patients with gastric adenocarcinoma who are eligible for radical treatment

Bosch

Chicklore

Cook

et al. 2019

Eur J Nucl Med Mol Imaging

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“…There was no correlation between patients' serum CEA levels and lesions' maximum standardized uptake values. Gauthe et al reported PET/CECT's sensitivity and specificity in detection of tumour recurrence in colorectal cancer (CRC) patients with elevated CEA as 94.1 and 77.2%, respectively [ 9 ]. This patient's peak post-operative CEA was 14.8 g/dl when he presented 48 months after his initial surgical resection with his symptoms.…”

Section: Discussionmentioning

confidence: 99%

Entero-enteric fistula from the stump of an end-to-side ileocolic anastomosis mimicking cancer recurrence

et al. 2015

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Enteric fistulae are a complex and technically frustrating complication of any bowel surgery. The constellation of associated non-specific symptoms often leads to extensive investigation and, in this case, suspicion of disease recurrence. A 71-year-old gentleman with a history of previous colorectal cancer presented with chronic diarrhoea, weight loss and left lower quadrant pain. Elective exploratory laparoscopy was performed to investigate possible disease recurrence due to elevated carcinoembryonic antigen levels and a positron emission tomography positive area within the mesentery. A jejunal–ileal fistula was found at laparotomy where the blind ileal stump of the end-to-side ileocolic anastomosis had fistulated into the jejunum. Resection of the affected jejunum was performed with end-to-end jejuno-jejunal re-anastomosis and stapling of the ileal stump. Specimen histology was negative for recurrence. Intestinal fistulae represent a diagnostic challenge. This is the first case report describing an enteric fistula mimicking cancer recurrence.

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“…Вместе с тем визуализация очаговых образований является показанием для более тщательного обследования, поскольку с большей долей вероятности свидетельствует о наличии онкологического процесса. В 75-88 % случаев фокальные накопления РФП в ободочной кишке связаны со злокачественными или предраковыми образованиями, подтверждёнными эндоскопическим исследованием, из которых 28-67 % являются предраковыми процессами, 20-46 % составляют аденокарциномы и 13-30 %доброкачественные опухоли [17]. [21].…”

Section: первичная диагностика кррunclassified

The Value of Pet/Ct in the Diagnosis, Stading and Monitoring of Colorectal Cancer

et al. 2019

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The purpose of the study was to provide up-to-date data on the efficacy of positron emission computed tomography (PET) for the diagnosis, assessment of tumor extension and monitoring of colorectal cancer.Material and Methods. The Medline and Pubmed databases were used for searching for publications devoted to clinical trials of diagnostic value of PET with 18F-Ftordesoxyglucose (PET with 18F-FDG).Results. Data on the value of PET with 18F-FDG in visualization of the primary tumor, detection of lymph node and distant metastases and assessment of the treatment response in patients with colorectal cancer were presented.Conclusion. PET with 18F-FDG was shown to be a promising imaging method for colorectal cancer. It is the most sensitive method in the detection of liver metastases. 18F-FDG PET is particularly superior to CT and MET in the ability to assess tumor response to treatment and predict early tumor response to therapy. The development of new radiopharmaceuticals for the diagnosis, staging, monitoring and prediction of colorectal cancer is of great importance.

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Role of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography in gastrointestinal cancers

Cited by 31 publications

References 177 publications

Staging FDG PET-CT changes management in patients with gastric adenocarcinoma who are eligible for radical treatment

Staging FDG PET-CT changes management in patients with gastric adenocarcinoma who are eligible for radical treatment

Entero-enteric fistula from the stump of an end-to-side ileocolic anastomosis mimicking cancer recurrence

The Value of Pet/Ct in the Diagnosis, Stading and Monitoring of Colorectal Cancer

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