Role of folate in nonalcoholic fatty liver disease

Sid, Victoria; Siow, Yaw L.; Karmin, O

doi:10.1139/cjpp-2016-0681

Cited by 66 publications

(51 citation statements)

References 321 publications

(651 reference statements)

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“…Folic acid: The role of folic acid in alcoholic liver disease is already well known, while being less clear in NAFLD. We noticed a statistically relevant increase in the consumption of folic acid in our NASH patients; despite various studies showing a deficiency of this vitamin in NAFLD subjects [ 56 , 57 ], previous studies have not found out any correlation between folic acid serum levels and NAFLD evolution [ 55 , 56 , 57 ]. Moreover, a study conducted on 10 NASH patients receiving folic acid supplement for six months resulted in no improvements in liver damage markers [ 58 ].…”

Section: Discussioncontrasting

confidence: 73%

Qualitative and Quantitative Evaluation of Dietary Intake in Patients with Non-Alcoholic Steatohepatitis

et al. 2017

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There are very few reports about the intake of nutrients for the development or progression of non-alcoholic steatohepatitis (NASH). The aim of this study was to identify the dietary habits and the nutrient intake in patients with NASH, in comparison to chronic hepatitis C (HCV)-related patients. We prospectively evaluated the intake of macronutrients and micronutrients in 124 NAFLD and 162 HCV patients, compared to 2326 subjects as a control group. We noticed major differences in macro- and micronutrients intakes in NASH and HCV patients compared to controls. Proteins, carbohydrate (glucose, fructose, sucrose, maltose and amide), saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), folic acid, vitamin A and C (p < 0.0001), and thiamine (p < 0.0003) ingestion was found to be higher in patients with NASH, while total lipids, polyunsaturated fatty acid (PUFA), riboflavin and vitamin B6 daily intake were lower compared to controls (p < 0.0001). Similarly, NASH patients had significantly reduced carbohydrate intake (p < 0.0001) and an increased intake of calcium (p < 0.0001) compared to HCV positive patients. Finally, we showed in NASH males an increase in the intake of SFA, PUFA, soluble carbohydrates (p < 0.0001) and a decrease in the amount of fiber (p < 0.0001) compared to control males. In NASH female population, we showed an increase of daily total calories, SFA, MUFA, soluble carbohydrates, starch and vitamin D ingested (p < 0.0001) with a reduction of fibers and calcium (p < 0.0001) compared to control females. This study showed how NASH patients’ diets, in both male and females, is affected by a profound alteration in macro- and micronutrients intake.

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Section: Discussioncontrasting

confidence: 73%

Qualitative and Quantitative Evaluation of Dietary Intake in Patients with Non-Alcoholic Steatohepatitis

et al. 2017

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“…Folate plays an essential role in lipid metabolism and folic acid supplementation can attenuate steatosis and improve oxidative stress in rodent models of NAFLD. Folate can also blunt the increase of inflammatory cytokines secreted by immune cells 32. Resveratrol has antioxidant, antiapoptotic and anti-inflammatory properties in patients with NAFLD 33.…”

Section: Discussionmentioning

confidence: 99%

Association between nut intake and non-alcoholic fatty liver disease risk: a retrospective case-control study in a sample of Chinese Han adults

et al. 2019

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ObjectivesNut consumption has been associated with a lower risk of type 2 diabetes, metabolic syndrome and insulin resistance. However, its effect on the risk of non-alcoholic fatty liver disease (NAFLD) is unknown. Therefore, we investigated the relationship between nut consumption and NAFLD risk.Setting and participantsWe conducted a retrospective case-control study including 534 patients diagnosed with NAFLD and 534 controls matched by sex and age (±5 years) from the Affiliated Nanping First Hospital of Fujian Medical University in China.Main outcome measuresInformation on dietary intake was collected using a semiquantitative food frequency questionnaire and nut consumption was calculated. Nut consumption was categorised using quartiles based on the distribution of daily nut intake of the controls. Binary logistic regression models were used to estimate ORs and the 95% CIs for the association between nut consumption and NAFLD risk.ResultsAfter adjusting for potential confounding variables, nut consumption was not associated with NAFLD risk in the overall sample. When the fully adjusted model was stratified by sex, a significant inverse association was found between high nut consumption and NAFLD only among the men in the highest quartile (OR=0.43; 95% CI 0.26 to 0.71;Ptrend =0.01). The inverse association of nut consumption with NAFLD risk in men remained significant after controlling for other known or suspected risk factors for NAFLD.ConclusionsDiets with a higher intake of nuts may be associated with a decreased risk of NAFLD, particularly in men.

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“…There is currently no pharmacological agent approved for the treatment of NAFLD (Schuppan and Schattenberg, 2013;Sid et al, 2017). Folic acid is a water-soluble B vitamin that has been shown to modulate lipid metabolism and oxidative stress (Sarna et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Folic Acid Supplementation Attenuates Chronic Hepatic Inflammation in High‐Fat Diet Fed Mice

Sid

Shang

Siow

et al. 2018

Lipids

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Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease worldwide. Hepatic inflammation is an important pathogenic mediator of NAFLD. There is currently no pharmacological agent approved for the treatment of NAFLD. Folic acid is a water‐soluble B vitamin that has been shown to have lipid‐lowering and antioxidant effects. The objective of this study was to investigate the effect of folic acid supplementation on hepatic inflammation and to identify the underlying mechanisms. Male C57BL/6 J mice were fed a control diet (10% kcal fat), a high‐fat diet (HFD) (60% kcal fat), or a HFD supplemented with folic acid (26 mg/kg diet) for 8 weeks. HFD feeding led to increased body mass gain, lipid accumulation, activation of transcription factor nuclear factor‐κB (NF‐κB), and elevation of inflammatory cytokine gene expression in the liver. Folic acid supplementation attenuated hepatic lipid accumulation and aggregation of inflammatory foci induced by HFD feeding. This was associated with a significant reduction of NF‐κB activation and inflammatory cytokine expression. These results suggest that the hepatoprotective effect of folic acid in NAFLD may be attributed, in part, to its anti‐inflammatory action.

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Role of folate in nonalcoholic fatty liver disease

Cited by 66 publications

References 321 publications

Qualitative and Quantitative Evaluation of Dietary Intake in Patients with Non-Alcoholic Steatohepatitis

Qualitative and Quantitative Evaluation of Dietary Intake in Patients with Non-Alcoholic Steatohepatitis

Association between nut intake and non-alcoholic fatty liver disease risk: a retrospective case-control study in a sample of Chinese Han adults

Folic Acid Supplementation Attenuates Chronic Hepatic Inflammation in High‐Fat Diet Fed Mice

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