Role of free fatty acids on insulin resistance

Vazquez-Jimenez, J. Gustavo; Roura-Guiberna, Adriana; Jiménez-Mena, Luisa Reyna; Olivares-Reyes, J. Alberto

doi:10.24875/gmm.m18000092

Cited by 6 publications

(20 citation statements)

References 88 publications

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“…PUFAs perform a structural function, being important components of the cell membrane and determining its physical and chemical properties [ 10 , 16 ]. The efficiency of glucose transport and expression of many receptors depend on the composition and ratio of PUFAs in the cell membrane [ 17 ]. Also, PUFAs are the precursors for inflammatory and pro-resolving lipids mediators' synthesis [ 29 , 32 ].…”

Section: Polyunsaturated Fatty Acids and Metabolic Syndrome Riskmentioning

confidence: 99%

“…This process impairs the association between TAB1 and the kinase activated by the growth factor beta (TAK1) and, consequently, results in reduced TAK1 activation and decreases the activity of the IKK- β /NF- κ B and JNK/AP-1 signaling pathways. The mitigation of TAK-1 activation by n-3 PUFAs leads to the reduced expression of TNF- α and IL-6 genes with proinflammatory actions [ 17 , 57 ].…”

Section: Polyunsaturated Fatty Acids and Metabolic Syndrome Riskmentioning

confidence: 99%

“…As FAs are insoluble in water, they are transported by binding to plasma albumin. FFAs can be taken up from circulating plasma by all mitochondria-containing cells, and they are metabolized by β -oxidation [ 17 ]. FFAs carry out many important biological functions in the body, and they are a source of energy, signal molecules, and structural components of cell membranes [ 17 ].…”

Section: Free Fatty Acids and Metabolic Syndrome Riskmentioning

confidence: 99%

“…FFAs can be taken up from circulating plasma by all mitochondria-containing cells, and they are metabolized by β -oxidation [ 17 ]. FFAs carry out many important biological functions in the body, and they are a source of energy, signal molecules, and structural components of cell membranes [ 17 ]. FFAs are involved in the pathogenesis of insulin resistance and subsequent development of metabolic syndrome [ 12 , 17 , 87 ].…”

Section: Free Fatty Acids and Metabolic Syndrome Riskmentioning

confidence: 99%

“…It is well known that excessive consumption of saturated fats contributes to the development of obesity and related diseases [ 19 ]. It has now been shown that high plasma levels of free fatty acids (FFAs), particularly saturated fatty acids (SFAs), may be associated with insulin resistance in obese patients with type 2 diabetes mellitus [ 17 ]. The lack of polyunsaturated fatty acids (PUFAs), especially n-3 PUFAs, some phospholipids, and plasmalogens in the cell membrane, is the cause of changes in glucose-insulin homeostasis and the development of inflammation [ 10 , 13 , 20 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Lipid-Induced Mechanisms of Metabolic Syndrome

et al. 2020

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Metabolic syndrome (MetS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnosis, approaches to the prevention, and treatment of this pathology. Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the background of abdominal obesity. In light of recent evidence, it has been shown that lipids, especially fatty acids (FAs), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators. On the one hand, the lack of n-3 polyunsaturated fatty acids (PUFAs) in the body leads to impaired molecular mechanisms of glucose transport, the formation of unresolved inflammation. On the other hand, excessive formation of free fatty acids (FFAs) underlies the development of oxidative stress and mitochondrial dysfunction in MetS. Understanding the molecular mechanisms of the participation of FAs and their metabolites in the pathogenesis of MetS will contribute to the development of new diagnostic methods and targeted therapy for this disease. The purpose of this review is to highlight recent advances in the study of the effect of fatty acids as modulators of insulin response and inflammatory process in the pathogenesis and treatment for MetS.

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Section: Polyunsaturated Fatty Acids and Metabolic Syndrome Riskmentioning

confidence: 99%

Section: Polyunsaturated Fatty Acids and Metabolic Syndrome Riskmentioning

confidence: 99%

Section: Free Fatty Acids and Metabolic Syndrome Riskmentioning

confidence: 99%

Section: Free Fatty Acids and Metabolic Syndrome Riskmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lipid-Induced Mechanisms of Metabolic Syndrome

et al. 2020

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Nuritional care for the remission of type 2 diabetes in adults undergoing metabolic surgery: a narrative review and propose of educational tool

Alejandra¹

2019

AOWMC

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Chronic non-communicable diseases (NCDs) are the principal cause of death in the world. In Mexico, type 2 diabetes (T2D) is the leading cause of death. An increase of 5kg/m2 in the body mass index (BMI) significantly increased the mortality by T2D. Metabolic surgery is an alternative treatment for people who are living with obesity and T2D. Metabolic surgical procedures induce anatomo-physiological changes, which improves glycemic control, decreases the risk of mortality due to T2D, promotes weight loss, and body fat, and in some cases, have the potential for the remission of T2D. These surgeries impact nutritional status in the short, medium and long term, therefore, a nutritionist should evaluate and implement nutrition interventions in these individuals. There are no guidelines for nutrition to promote and maintain remission of T2D in individuals with these types of surgeries. The objective of this review is to summarize current scientific evidence to guide the clinical practice in this context. The therapeutic goals include, besides promoting weight loss, monitor waist circumference and body composition, evaluation of glycemic control with regulation of hypoglycemic drugs, and avoiding nutritional deficiencies. For adequate results it is recommended to incorporate behavioral strategies and nutritional education focused on healthy and sustainable eating patterns. Adequate nutritional monitoring favors a better prognosis in the fulfillment of therapeutic objectives of both diseases after metabolic surgery.

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Impact of Lipids on Insulin Resistance: Insights from Human and Animal Studies

Elkanawati,

Sumiwi,

Levita

2024

DDDT

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Insulin resistance (IR) is a complex pathological condition central to metabolic diseases such as type 2 diabetes mellitus (T2DM), cardiovascular disease, non-alcoholic fatty liver disease, and polycystic ovary syndrome (PCOS). This review evaluates the impact of lipids on insulin resistance (IR) by analyzing findings from human and animal studies. The articles were searched on the PubMed database using two keywords: (1) “Role of Lipids AND Insulin Resistance AND Humans” and (2) “Role of Lipids AND Insulin Resistance AND Animal Models”. Studies in humans revealed that elevated levels of free fatty acids (FFAs) and triglycerides (TGs) are closely associated with reduced insulin sensitivity, and interventions like metformin and omega-3 fatty acids show potential benefits. In animal models, high-fat diets disrupt insulin signaling and increase inflammation, with lipid mediators such as diacylglycerol (DAG) and ceramides playing significant roles. DAG activates protein kinase C, which eventually impairs insulin signaling, while ceramides inhibit Akt/PKB, further contributing to IR. Understanding these mechanisms is crucial for developing effective prevention and treatment strategies for IR-related diseases.

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Role of free fatty acids on insulin resistance

Cited by 6 publications

References 88 publications

Lipid-Induced Mechanisms of Metabolic Syndrome

Lipid-Induced Mechanisms of Metabolic Syndrome

Nuritional care for the remission of type 2 diabetes in adults undergoing metabolic surgery: a narrative review and propose of educational tool

Impact of Lipids on Insulin Resistance: Insights from Human and Animal Studies

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