Role of G protein-coupled receptors in inflammation

Sun, Lei; Ye, Richard D.

doi:10.1038/aps.2011.200

Cited by 153 publications

(131 citation statements)

References 105 publications

Supporting

Mentioning

130

Contrasting

Order By: Relevance

“…It should be noted in this context that activation of chemoattractant GPCRs, including the fMLF and C5a receptors, also promotes ROS production in neutrophils in a G i -dependent fashion (47). In these cells, ROS accumulation requires the activity of multiple signaling pathways including the activation of PI3 kinase and the small GTPase Rac (47).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatic Gi signaling regulates whole-body glucose homeostasis

Rossi¹,

Zhu²,

McMillin³

et al. 2018

Journal of Clinical Investigation

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…In these cells, ROS accumulation requires the activity of multiple signaling pathways including the activation of PI3 kinase and the small GTPase Rac (47). It remains to be explored whether similar signaling cascades are involved in G i -mediated ROS production in hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Gi signaling regulates whole-body glucose homeostasis

Rossi¹,

Zhu²,

McMillin³

et al. 2018

Journal of Clinical Investigation

View full text Add to dashboard Cite

“…Inflammatory mediators modulate GRKs signaling either by transcription regulation or its degradation. GRK2 act as mediator in the pathway that causes inflammatory pain (Sun and Richard, 2012). Thus, targeting GRKS by P. longum could be the reason of its anti-inflammatory properties.…”

Section: Module and Go Enrichment Analysis Of Human Pinmentioning

confidence: 99%

Piper longum: A review of its phytochemicals and their network pharmacological evaluation

Choudhary¹,

Singh²

2017

Preprint

View full text Add to dashboard Cite

Absorption Distribution Metabolism Excretion Toxicity ADMETModule and GO analysis AbstractPiper longum L. (P. longum, also called as long pepper) is one of the common culinary herb and has been extensively used as an important constituent of various indigenous medicines, specifically in traditional Indian medicinal system known as Ayurveda. Towards obtaining a global regulatory framework of P. longum's constituents, in this work we first reviewed phytochemicals present in this herb and then studied their pharmacological and medicinal features using network pharmacology approach. We developed high-confidence level tripartite networks consisting of phytochemicals -protein targets -disease association and explain the role of its phytochemicals to various chronic diseases. 7 drug-like phytochemicals in this herb were found as the potential regulators of 5 FDA approved drug targets; and 28 novel drug targets were also reported. 105 phytochemicals were linked with immunomodulatory potency by pathway level mapping in human metabolic network. A sub-network of human PPI regulated by its phytochemicals was derived and various modules in this sub-network were successfully associated with specific diseases.

show abstract

“…thrombomodulin (TM) (which binds thrombin) and endothelial protein C receptor (EPCR) [42]. It has been demonstrated that cell receptor occupancy is one of the critical factors determining the switch in the effects of thrombin from anticoagulant (TM/EPCR-mediated generation of activated protein C) to proinflammatory action, mediated through PAR-1 [43][44][45]. At the same time, the interplay of environmental inflammatory factors may direct the effects of FVIIc-TF signaling towards proinflammatory actions, depending on the availability of TF-inhibiting forces (TF pathway inhibitor [TFPI]) and cellular receptors that act in concert with FVIIc-TF, including PAR-2 [46].…”

Section: Coagulation and Thrombosismentioning

confidence: 99%

The Northwick Park Heart Study: evidence from the laboratory

Cate

Meade

2014

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

Abstract. The Northwick Park Heart Study (NPHS) has shown associations of high plasma fibrinogen and factor VII (FVIIc) levels with the risk of death from coronary heart disease (CHD). The finding for fibrinogen has been confirmed in many other studies. Whereas one further study has found a similar prospective association for FVIIc, several have not. Experimental studies have demonstrated the impact that the coagulation activity of fibrinogen and FVIIc have on the progression and phenotype of atherosclerotic lesions. FVIIc-driven thrombin generation and fibrin formation within the vessel wall are important determinants of both plaque (in)stability and atherothrombosis. In blood, local concentrations of FVIIc and thrombin may be sufficient to allow interactions between these serine proteases and protease-activated receptors, to drive cellular inflammatory reactions that further promote these processes. Local fibrinogen concentrations dictate fibrin clot structure and resistance to fibrinolysis. Within the atherosclerotic plaque, coagulation reactions driven by proinflammatory stimuli may initially support lesion stability (as part of wound healing), but, with advanced inflammation, thrombin and fibrin generation diminish because of proteolytic activity contributing to plaque instability. The NPHS findings have proved controversial, but, in the light of current knowledge, a reappraisal of the importance of FVIIc and fibrinogen in atherosclerosis, atherothrombosis and CHD is justified. Hypercoagulability, reflected in turn by thrombin generation capacity, and local concentrations of coagulation proteins, including FVIIc and fibrinogen, is linked to plaque phenotype, and even minute local concentrations of fibrinogen and proteases such as FVIIc may affect thrombin generation capacity.

show abstract

Role of G protein-coupled receptors in inflammation

Cited by 153 publications

References 105 publications

Hepatic Gi signaling regulates whole-body glucose homeostasis

Hepatic Gi signaling regulates whole-body glucose homeostasis

Piper longum: A review of its phytochemicals and their network pharmacological evaluation

The Northwick Park Heart Study: evidence from the laboratory

Contact Info

Product

Resources

About