Role of galectin-3 in autoimmune and non-autoimmune nephropathies

Saccon, Francesca; Gatto, Mariele; Ghirardello, Anna; Iaccarino, Leonardo; Punzi, Leonardo; Doria, Andrea

doi:10.1016/j.autrev.2016.09.023

Cited by 55 publications

(36 citation statements)

References 134 publications

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“…Recently, Gal-3 has been indicated to be involved in the following broad pathological processes: Inflammation [9], fibrosis, cell-to-cell [10,11] or cell-to-matrix [12] contacts, cell proliferation [13,14], and protection from apoptosis [15,16]. Furthermore, many studies have revealed that Gal-3 expression is detected in many disease conditions, such as heart disease [17][18][19][20][21][22][23], kidney disease [24][25][26][27], diabetes mellitus [24,25,28], viral infection [29][30][31][32], autoimmune disease [33][34][35][36], neurodegenerative disorders [37][38][39][40][41][42], and tumor formation [43][44][45][46][47][48][49][50][51][52].…”

Section: Clinical Significance and Applications Of Galectine-3 (Gal-3)mentioning

confidence: 99%

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Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases

et al. 2020

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Galectin-3 is a β-galactoside-binding lectin which is important in numerous biological activities in various organs, including cell proliferation, apoptotic regulation, inflammation, fibrosis, and host defense. Galectin-3 is predominantly located in the cytoplasm and expressed on the cell surface, and then often secreted into biological fluids, like serum and urine. It is also released from injured cells and inflammatory cells under various pathological conditions. Many studies have revealed that galectin-3 plays an important role as a diagnostic or prognostic biomarker for certain types of heart disease, kidney disease, viral infection, autoimmune disease, neurodegenerative disorders, and tumor formation. In particular, it has been recognized that galectin-3 is extremely useful for detecting many of these diseases in their early stages. The purpose of this article is to review and summarize the recent literature focusing on the biomarker characteristics and long-term outcome predictions of galectin-3, in not only patients with various types of diseases, but associated animal models.

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Section: Clinical Significance and Applications Of Galectine-3 (Gal-3)mentioning

confidence: 99%

“…Studies in animal models demonstrate that Gal-3 plays a pivotal role in several nephropathies [36]. In several animal models of CKD, inhibition or suppression of Gal-3 has a protective effect on CKD outcomes.…”

Section: Gal-3 In Animal Data For Ckdmentioning

confidence: 99%

Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases

et al. 2020

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“…Galectins constitute a large family of β-galactoside binding lectins, and galectin-3 is known to promote cell migration by modulating cell-cell adhesion and cell-matrix adhesion which are critical aspects for embryogenesis, inflammation as well as for cancer dissemination. 97 It is strongly expressed in the ureteric bud and its derivatives, and its upregulation is critical in controlling the ureteric bud branching, thus it promotes nephrogenesis during development. 98 Galectin-3 has also been reported to play a role in ameliorating ischemic and nephrotoxic AKI.…”

Section: Other Compoundsmentioning

confidence: 99%

“…Elevated plasma galectin-3 levels are also associated with increased risks of rapid renal function decline, incidence of CKD, and progressive renal impairment. 97 98 Galectin-3 has been proposed as a potential therapeutic target for the treatment of CKD, and currently clinical trials using a galectin-3 inhibitor are under investigation. 98 100 …”

Section: Other Compoundsmentioning

confidence: 99%

Bioactive Compounds for the Treatment of Renal Disease

Yoo

2018

Yonsei Med J

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Kidney diseases including acute kidney injury and chronic kidney disease are among the largest health issues worldwide. Dialysis and kidney transplantation can replace a significant portion of renal function, however these treatments still have limitations. To overcome these shortcomings, a variety of innovative efforts have been introduced, including cell-based therapies. During the past decades, advances have been made in the stem cell and developmental biology, and tissue engineering. As part of such efforts, studies on renal cell therapy and artificial kidney developments have been conducted, and multiple therapeutic interventions have shown promise in the pre-clinical and clinical settings. More recently, therapeutic cell-secreting secretomes have emerged as a potential alternative to cell-based approaches. This approach involves the use of renotropic factors, such as growth factors and cytokines, that are produced by cells and these factors have shown effectiveness in facilitating kidney function recovery. This review focuses on the renotropic functions of bioactive compounds that provide protective and regenerative effects for kidney tissue repair, based on the available data in the literature.

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“…A função extracelular dessa proteína é dependente da propriedade lectina do domínio Cterminal, podendo ser inibida por ligantes sacarídicos específicos como a lactose (SANO et al, 2000). Pode ser encontrada em diversos tecidos, como tratos digestivo e urogenital, pulmões, sangue, rins e coração; e é presente no núcleo, citoplasma, superfície celular e pode ser secretada para o meio extracelular (CHEN et al, 2016;KOBAYASHI et al, 2014;NISHI et al, 2007;SACCON et al, 2017;YAN et al, 2016).…”

Section: Galectina-3unclassified

Propriedades biológicas das proteínas Galectina-3 e rP21 na infecção por Trypanosoma cruzi in vitro e in vivo

Silva¹

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Role of galectin-3 in autoimmune and non-autoimmune nephropathies

Cited by 55 publications

References 134 publications

Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases

Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases

Bioactive Compounds for the Treatment of Renal Disease

Propriedades biológicas das proteínas Galectina-3 e rP21 na infecção por Trypanosoma cruzi in vitro e in vivo

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