Role of Gender and Serum Immunoglobulin E (IGE) levels on Severity of Migraine

Rosario, David; Pinto, George

doi:10.7860/jcdr/2014/7516.4007

Cited by 10 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Abramson) based on a previous study that correlated allergic sensitization characterized by high blood levels of IgE with greater disability due to headache in 100 migraine patients 18 .…”

Section: Statisticsmentioning

confidence: 99%

The influence of allergic rhinoconjunctivitis on migraine disability in children

Forcelini

Ramos

Santos

et al. 2019

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Migraine is a common condition in the pediatric population and causes a significant impact on the quality of life. Atopic disorders are some of the migraine comorbidities. Objective We hypothesized that allergic rhinitis could aggravate migraine in the pediatric population. Methods This cross-sectional study consecutively evaluated 90 pediatric outpatients (46 children 6–12 years of age; 44 adolescents up to 18 years of age) who sought medical assistance because of migraine at a general neurology clinic in Passo Fundo, RS, Brazil. They, and their parents, were given three questionnaires, to evaluate the diagnosis of current allergic rhinitis, allergic rhinoconjunctivitis and seasonal allergic rhinitis, as well as the disability caused by headache (ISAAC - International Study of Asthma and Allergies in Childhood; CARATkids - Control of Allergic Rhinitis and Asthma Test for Children; PedMIDAS - Pediatric Migraine Disability Assessment). The study was approved by the local ethics committee. Results According to the ISAAC questionnaire, children with current allergic rhinoconjunctivitis in the last year showed higher scores on the PedMIDAS than those patients without atopy (median and interquartile range 26 [10–58] vs. 5 [1–13], p = 0.008). A significant positive correlation of CARATkids scores with PedMIDAS scores was found (p = 0.007, rho = 0.39). After including other putative predictors of migraine disability (age, body mass index, time since onset of migraine) in a multiple regression analysis, only the scores on the CARATkids remained a significant independent variable correlated with PedMIDAS scores (p = 0.001; R = 0.55; R2 = 0.30). Conclusions Current allergic rhinoconjunctivitis is related to enhanced disability caused by headache in childhood migraine.

show abstract

“…Abramson) based on a previous study that correlated allergic sensitization characterized by high blood levels of IgE with greater disability due to headache in 100 migraine patients 18 .…”

Section: Statisticsmentioning

confidence: 99%

The influence of allergic rhinoconjunctivitis on migraine disability in children

Forcelini

Ramos

Santos

et al. 2019

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…Similarly, in a prospective study, Theodoropoulos et al [ 58 ] observed that interictal serum C-reactive protein levels declined and the severity of migraines and rhinitis decreased during sublingual immunotherapy. Immunotherapy induces tolerance to specific allergens through two mechanisms of action: by altering cytokine responses of T helper cells and by promoting IgG and IgA, antibodies that block the binding of IgE to mast cells [ 59 – 61 ]. Data from another study revealed a correlation between serum IgE levels and the severity and frequency of migraines: patients with higher levels of IgE had more severe headaches than those with lower levels of IgE [ 61 ].…”

Section: Comorbidity and Pathophysiologymentioning

confidence: 99%

“…Immunotherapy induces tolerance to specific allergens through two mechanisms of action: by altering cytokine responses of T helper cells and by promoting IgG and IgA, antibodies that block the binding of IgE to mast cells [ 59 – 61 ]. Data from another study revealed a correlation between serum IgE levels and the severity and frequency of migraines: patients with higher levels of IgE had more severe headaches than those with lower levels of IgE [ 61 ]. These data support the hypothesis that migraine severity and disability depend on coexisting allergic rhinitis, which might provide an interesting rationale for treatments targeted at reducing migraine intensity and disability among patients with coexisting allergy and migraine; however, further investigation is needed.…”

Section: Comorbidity and Pathophysiologymentioning

confidence: 99%

Allergic Rhinitis and Chronic Daily Headaches: Is There a Link?

Gryglas

2016

Curr Neurol Neurosci Rep

View full text Add to dashboard Cite

Allergic rhinitis and migraine remain on the list of the most common diseases affecting adults. Migraines and headaches due to allergic rhinitis are easily confused because the symptoms of both conditions often overlap. Both may occur with sinus headache, nasal congestion, and lacrimation and may worsen with weather changes and exposure to allergens. No precise clinical definition exists for what constitutes a sinus headache, which has always been a diagnostic dilemma. Contrary to popular belief, headache is not a typical symptom of rhinitis. Some studies have shown that up to 90 % of sinus headaches are actually migraines. Nevertheless, patients with self-diagnosed sinus headache self-treat or are treated by primary care physicians and/or otolaryngologists with medications for rhinosinusitis, ignoring the neurogenic causes of the symptoms when most of these patients fulfill diagnostic criteria for chronic migraine. Chronic migraine affects 2 % of the general population and has a significant socioeconomic impact on society, incurring health care costs and diminishing quality of life; therefore, the proper diagnosis and treatment of these headache patients should be a priority.

show abstract

“…No patient declined participation during the period of this research, which was conducted in accordance with the Declaration of Helsinki and was approved by the Ethical Committee of Universidade de Passo Fundo on October 18, 2016 (report number 1.779.204). Sample size was estimated with the aid of software WinPepi version 11.50 (J. H. Abramson) based on previous results from Rosario and Pinto who correlated allergic sensitization characterized by high blood levels of IgE with greater disability due to headache in 100 migraineurs 19 .…”

Section: Methodsmentioning

confidence: 99%

“…Such rich inflammatory processes that take place in allergic rhinitis could theoretically predispose the patient to migraine worsening, not only through cephalic nociceptive pathways, but also by triggering an immune response not necessarily restricted to the head. For example, allergic sensitization measured by serum immunoglobulin E (IgE) has already been linked to aggravated migraine in adults 19 .…”

mentioning

confidence: 99%

Is allergic rhinitis related to migraine disability in adults?

Forcelini

Gradaschi

Tonin

et al. 2019

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

Migraine is a chronic condition with complex pathophysiology. Although immunologic disturbances have been linked to migraine, only few attempts have been made to assess the possibility of allergic rhinitis as a worsening factor of migraine in adults. Objective This survey aimed to compare migraine disability between adult migraineurs with and without current allergic rhinitis. Methods This cross-sectional study comprised 118 adult migraineurs who were consecutively assisted at an outpatient clinic. After ordinary neurological evaluation, participants were evaluated for headache disability using the Migraine Disability Assessment (MIDAS). The presence of current allergic rhinitis, allergic rhinoconjunctivitis and seasonal allergic rhinitis was scored for each participant according to the International Study of Asthma and Allergies in questionnaire. Results There was no significant difference between the MIDAS scores of those with current allergic rhinitis, allergic rhinoconjunctivitis, or seasonal allergic rhinitis and nonatopic migraineurs. The disability caused by allergic symptoms also did not influence the MIDAS scores of patients with allergic rhinitis. The frequency of headache days during the last three months was higher in the subset of patients without allergic rhinitis (median and interquartile range 12 [8–19.2] vs. 8 [4–14]; p = 0.03). Conclusions Our results suggest that current allergic rhinitis, allergic rhinoconjunctivitis, and seasonal allergic rhinitis are not related to headache disability in adults with episodic migraine.

show abstract

Role of Gender and Serum Immunoglobulin E (IGE) levels on Severity of Migraine

Cited by 10 publications

References 7 publications

The influence of allergic rhinoconjunctivitis on migraine disability in children

The influence of allergic rhinoconjunctivitis on migraine disability in children

Allergic Rhinitis and Chronic Daily Headaches: Is There a Link?

Is allergic rhinitis related to migraine disability in adults?

Contact Info

Product

Resources

About