Role of ghrelin axis in colorectal cancer: A novel association

Waseem, Talat; Javaid-ur-Rehman,; Ahmad, Farooq; Azam, Muhammad; Qureshi, Mansoor Ahmad

doi:10.1016/j.peptides.2008.03.020

Cited by 77 publications

(96 citation statements)

References 32 publications

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“…6,7 Therefore, there is considerable interest in a possible role of ghrelin as an orexigenic peptide for the treatment of anorexia. [21][22][23][24] Ghrelin is synthesized mainly in the upper third of the stomach with direct and indirect effects in the area postrema, the nucleus of the solitary tract, the nucleus of hypothalamus, and the brainstem, but it also may have direct and indirect metabolic effects on cells outside the central nervous system. [25][26][27][28][29][30][31][32] Figure 2.…”

Section: Discussionmentioning

confidence: 99%

Effects by daily long term provision of ghrelin to unselected weight‐losing cancer patients

Lundholm

Gunnebo

Körner

et al. 2010

Cancer

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BACKGROUND:The short-term provision of ghrelin to patients with cancer indicates that there may be benefits from long-term provision of ghrelin for the palliative treatment of weight-losing cancer patients. This hypothesis was evaluated in a randomized, double-blind, phase 2 study. METHODS: Weight-losing cancer patients with solid gastrointestinal tumors were randomized to receive either high-dose ghrelin treatment (13 lg/kg daily; n ¼ 17 patients) or low-dose ghrelin treatment (0.7 lg/kg daily; n ¼ 14 patients) for 8 weeks as a once-daily, subcutaneous injections. Appetite was scored on a visual analog scale; and food intake, resting energy expenditure, and body composition (dual x-ray absorpitometry) were measured before the start of treatment and during follow-up. Serum levels of ghrelin, insulin, insulin-like growth factor 1, growth hormone (GH), triglycerides, free fatty acids, and glucose were measured. Health-related quality of life, anxiety, and depression were assessed by using standardized methods (the 36-item Short Form Health Survey and the Hospital Anxiety and Depression Scale). Physical activity, rest, and sleep were measured by using a multisensor body monitor. RESULTS: Treatment groups were comparable at inclusion. Appetite scores were increased significantly by high-dose ghrelin analyzed both on an intent-to-treat basis and according to the protocol. High-dose ghrelin reduced the loss of whole body fat (P < .04) and serum GH (P < .05). There was a trend for high-dose ghrelin to improve energy balance (P < .07; per protocol). Otherwise, no statistically significant differences in outcome variables were observed between the high-dose and low-dose groups. Adverse effects were not observed by high-dose ghrelin, such as serum levels of tumor markers (cancer antigen 125 [CA 125], carcinoembryonic antigen,. CONCLUSIONS: The current results suggested that daily, long-term provision of ghrelin to weight-losing cancer patients with solid tumors supports host metabolism, improves appetite, and attenuates catabolism.

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Section: Discussionmentioning

confidence: 99%

Effects by daily long term provision of ghrelin to unselected weight‐losing cancer patients

Lundholm

Gunnebo

Körner

et al. 2010

Cancer

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“…The ghrelin expression has been described in several endocrine and non-endocrine tumors and related cell lines in humans, such as: thyroid follicular cancer and parathyroid adenomas (Volante et al 2003, Raghay et al 2006, pituitary adenomas and other neuroendocrine tumors (Kim et al 2001, Korbonits et al 2001, Wasko et al 2008, oral squamous cell carcinoma (Alnema et al 2010), gastric carcinoids and colon cancer , Waseem et al 2008, pancreatic-related endocrine tumors (Duxbury et al 2003, Ekeblad et al 2007), renal carcinoma (Dagli et al 2009), bronchial carcinoid (Arnaldi et al 2003), testicular and ovarian tumors (Gaytan et al 2004(Gaytan et al , 2005, adrenocortical tumors (Barzon et al 2005), prostate cancer (Cassoni et al 2004, and breast cancer . Moreover, in these tissues the n-octanoylated ghrelin and des-acyl ghrelin concentrations might reach even higher levels than those in the blood, through local production.…”

Section: The Role Of Ghrelin In Cancermentioning

confidence: 99%

“…Another study showed the colorectal cancer cells proliferation and promotion of invasion by ghrelin in an autocrine and paracrine manner. This effect was almost completely abolished when the cells were pre-treated with either GHS-R antagonist (D-[Lys3]GHRP6) or a neutralizing ghrelin -specific antibody (Waseem et al 2008).…”

Section: The Role Of Ghrelin In Cancerogenesis -New Possibilitiesmentioning

confidence: 99%

A role of ghrelin in cancerogenesis

Majchrzak¹,

Szyszko²,

Pawłowski³

et al. 2012

Polish Journal of Veterinary Sciences

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Ghrelin is a 28 amino-acid multi-functional peptide hormone, which was identified as a natural ligand of the growth hormone secretagogue receptor (GHS-R). Pituitary growth hormone-releasing activity in both animals and humans has been well documented. It has various biological functions, including regulation of appetite and body weight, control of energy homeostasis, modulation of cardiovascular and gastrointestinal system and anti-inflammatory effect.However, both ghrelin and its receptor (GHS-R) are widely distributed in various tumors, which strongly implies their role in neoplastic cell growth trough autocrine/paracrine mechanism. Multiple studies have demonstrated the role of ghrelin in cancer cells proliferation, differentiation, invasiveness and apoptosis inhibition.The ghrelin axis is more complex than it was originally thought and consist of several compounds that might interact with each other and affect ghrelin activities. Here, we provide an overview of the ghrelin and its receptor role in tumor progression.

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“…It was shown that ghrelin treatment inhibited apoptosis in endometrial cancer (20), pheochromocytoma (21), and adrenocortical carcinoma cell lines (22). Ghrelin stimulates cell migration and invasion in pancreatic cell lines (15), colorectal cell lines (16), and astrocytoma cells (23). Nikolopoulos and cols.…”

Section: Resultsmentioning

confidence: 99%

Serum ghrelin levels in papillary thyroid carcinoma

Uçan

Şahi̇n

Kızılgül

et al. 2017

Arch. Endocrinol. Metab.

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Objective: Ghrelin plays a role in several processes of cancer progression, and numerous cancer types express ghrelin and its receptor. We aimed to investigate serum levels of ghrelin in patients with papillary thyroid carcinoma (PTC) and its association with the prognostic factors in PTC. Materials and methods: We enrolled 54 patients with thyroid cancer (7 male, 47 female) and 24 healthy controls (6 male, 18 female) in the study. We compared demographic, anthropometric, and biochemical data, and serum ghrelin levels between the groups. Serum ghrelin levels were measured using as enzyme-linked immunosorbent assay. Results: Ghrelin levels were similar between the groups, but plasma ghrelin levels were significantly higher in tumors larger than 1 cm diameter compared with papillary microcarcinomas. Serum ghrelin levels also correlated with tumor size (r = 0.499; p < 0.001). Body mass index, thyroid-stimulating hormone, and HOMA-IR levels were similar between the groups. There were no statistically significant differences regarding average age and other prognostic parameters including lymph node invasion, capsule invasion, multifocality and surgical border invasion between patients with microcarcinoma and tumors larger than 1 cm. Conclusion: In our study, no significant difference in serum ghrelin levels was determined between patients with papillary thyroid cancer and healthy controls however, serum ghrelin levels were higher in tumors larger than 1 cm compared to in those with thyroid papillary microcarcinoma. Arch Endocrinol Metab. 2017;61(5):464-9

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Role of ghrelin axis in colorectal cancer: A novel association

Cited by 77 publications

References 32 publications

Effects by daily long term provision of ghrelin to unselected weight‐losing cancer patients

Effects by daily long term provision of ghrelin to unselected weight‐losing cancer patients

A role of ghrelin in cancerogenesis

Serum ghrelin levels in papillary thyroid carcinoma

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