Role of Gram-Negative Sepsis in Lethal Toxicity Induced by Mycoplasma

The mycoplasmas.

“…Our present knowledge of the mycoplasma membrane composition, however, rules out the presence of any molecules resembling the classical bacterial lipopolysaccharides (see Membrane Lipids). Hence, it is not surprising that the toxemia due to M. fermentans cells or membranes differed in some important details from that caused by lipopolysaccharides (99,100), and the Limulus amoebocyte lysate coagulation test, capable of detecting extremely low doses of lipopolysaccharide, remained negative in mice injected with M. fermentans (92). Thus, the nature of the toxic factors in M. fermentans cells and membranes is still unclear (see also Organ Cultures as Experimental Systems).…”

Chronic Endometritis and Positive Mycoplasma Cultures: Is There a Correlation?

“…In 1977, Ruben and colleagues s demonstrated histologic evidence of severe inflammation of the fetal membranes in cows inoculated with mycoplasma. Gabridge 6 produced histopathology associated with lethal toxicity by inoculating germfree mice with mycoplasma isolated from humans.…”