Role of granulocyte colony-stimulating factor in human reproduction

Eftekhar, Maryam; Naghshineh, Elham; Khani, Parisa

doi:10.4103/jrms.jrms_628_17

Cited by 37 publications

(16 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Молекулярный анализ тканей женской репродуктивной системы продемонстрировал их экспрессию в лютеинизированных клетках гранулезы, плацентарных тканях, клетках трофобласта и ооцитах, что указывает на возможную роль G-CSF в регуляции не только менструального цикла, но и функции плацен-ты [1]. Присутствие G-CSF практически во всех отделах женской половой системы и орга нах плода свидетельствует о ключевой роли именно этого цитокина в большинстве циклических процессов эндометрия (репарации, дифференцировки, миграции, пролиферации) и в физиологическом течении беременности [21].…”

Section: роль G-csf в регуляции репродуктивной функцииunclassified

Granulocyte colony-stimulating factor as a checkpoint of the embryo invasive potential and endometrial receptivity

et al. 2019

View full text Add to dashboard Cite

Granulocyte colony-stimulating factor (G-CSF) promotes proliferation, survival, and differentiation of myeloid-lineage cells, as well as normal hematopoietic cells. The immunomodulating effects of G-CSF, which consist in stimulating the Th2 biased type immune response, prevent the development of graft-versus-host disease (GvHD) and, as a special case of GvHD, are responsible for the embryo implantation into the endometrium after the embryo transfer. G-CSF stimulates subpopulations of neutrophils, which display anti-inflammatory properties and are involved in tissue regeneration. The increased secretion of annexin A1 and IL-10 ensures the anti-inflammatory and immunomodulating effects of neutrophils. This review article presents data from four meta-analyzes aimed to explore the efficiency of G-CSF on infertile women undergoing in vitro fertilization. These data demonstrate an increase in the embryo implantation rate and clinical pregnancy rate, which is provided by the change in the endometrial receptivity and/or the invasive potential of the developing embryo.

show abstract

Section: роль G-csf в регуляции репродуктивной функцииunclassified

Granulocyte colony-stimulating factor as a checkpoint of the embryo invasive potential and endometrial receptivity

et al. 2019

View full text Add to dashboard Cite

show abstract

“…G-CSF is a cytokine (175 aa; MW = 18.8 kDa) with several physiological roles including the stimulation of hematopoietic cell proliferation, differentiation and maturation [12,13]. However, there is evidence supporting new physiological roles for G-CSF in other non-hemopoietic organs [12–14]. G-CSF is produced by Leydig and Sertoli cells in the testis and is present in the seminal plasma [14–18].…”

Section: Introductionmentioning

confidence: 99%

“…However, there is evidence supporting new physiological roles for G-CSF in other non-hemopoietic organs [12–14]. G-CSF is produced by Leydig and Sertoli cells in the testis and is present in the seminal plasma [14–18]. Moreover, G-CSF receptor CSF3R has been identified in murine SSCs [19].…”

Section: Introductionmentioning

confidence: 99%

Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals

Aponte¹,

Gutiérrez-Reinoso

Sanchez-Cepeda

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

The understanding of mammalian spermatogenesis niche factors active during sexual development may be leveraged to impact reproduction in farm animals. The aim of this study was to evaluate the effects of r-met-hu/G-CSF (filgrastim) on prepubertal sexual development of guinea pigs (Cavia porcellus) and ram lambs (Ovis aries). Individuals of both species were administered r-met-hu/G-CSF daily for 4 days. During and after administration protocols, testicular function and development were assessed through hematological responses, hormonal profiles (gonadotropins, testosterone and cortisol) testicular morphometry and germ cell kinetics. As expected, r-met-hu/G-CSF acutely mobilized white-lineage blood cells in both species. LH was increased by r-met-hu/G-CSF in guinea pigs (P<0.01) but T remained unchanged. In ram lambs gonadotropins and T increased in dose-response fashion (P<0.01) while cortisol values were stable and similar in treated and control animals (P>0.05). In guinea pigs there were no differences in testicular weights and volumes 2-mo after r-met-hu/G-CSF application (P>0.05). However, ram lambs showed a dose-response effect regarding testis weight (P<0.05). 66.66% of ram lambs had initial testes not yet in meiosis or starting the first spermatogenic wave. After 60-days only 25% of control animals were pubertal while all treated animals (1140-μg) had reached puberty. We propose an integrated hypothesis that G-CSF can stimulate spermatogenesis through two possible ways. 1) r-met-hu/G-CSF may go through the brain blood barrier and once there it can stimulate GnRH-neurons to release GnRH with the subsequent release of gonadotrophins. 2) a local testicular effect through stimulation of steroidogenesis that enhances spermiogenesis via testosterone production and a direct stimulation over spermatogonial stem cells self-renewal. In conclusion, this study shows that r-met-hu/G-CSF differentially affects prepubertal sexual development in hystricomorpha and ovine species, a relevant fact to consider when designing methods to hasten sexual developmental in mammalian species.

show abstract

“…Unexplained recurrent implantation failure is a major clinical unmet need in the treatment of female infertility, especially in the embryo transferring technique [ 31 ]. Thus, to improve the receptivity of the endometrium, many researchers have attempted to identify novel effective drugs or technologies such as intentional injury of the local endometrium [ 4 ], melatonin [ 32 ], prostaglandins [ 33 , 34 ], growth factors [ 35 , 36 ], and chemical drugs [ 37 , 38 ]. Several herbal drugs or their constituents have also been studied as potent candidates for the treatment of implantation failure [ 38 , 39 , 40 , 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Paeoniflorin Enhances Endometrial Receptivity through Leukemia Inhibitory Factor

et al. 2021

View full text Add to dashboard Cite

Despite advances in assisted reproductive technology, treatment for deficient endometrial receptivity is a major clinical unmet need. In our previous study, the water extract of Paeonia lactiflora Pall. enhanced endometrial receptivity in vitro and in vivo via induction of leukemia inhibitory factor (LIF), an interleukin (IL)-6 family cytokine. In the present study, we found that paeoniflorin, a monoterpene glycoside, is the major active compound of P. lactiflora. Paeoniflorin significantly improved the embryo implantation rate in a murine model of mifepristone (RU486)-induced implantation failure. In addition, paeoniflorin increased the adhesion of human trophectoderm-derived JAr cells to endometrial Ishikawa cells through the expression of LIF in vitro. Moreover, using the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database of the human endometrium, we confirmed that LIF signaling is a key regulator for improving human endometrial receptivity. Therefore, these results suggest that paeoniflorin might be a potent drug candidate for the treatment of endometrial implantation failure by enhancing endometrial receptivity.

show abstract

Role of granulocyte colony-stimulating factor in human reproduction

Cited by 37 publications

References 37 publications

Granulocyte colony-stimulating factor as a checkpoint of the embryo invasive potential and endometrial receptivity

Granulocyte colony-stimulating factor as a checkpoint of the embryo invasive potential and endometrial receptivity

Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals

Paeoniflorin Enhances Endometrial Receptivity through Leukemia Inhibitory Factor

Contact Info

Product

Resources

About