2021
DOI: 10.15789/1563-0625-rog-2287
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ROLE OF GSK-3 IN Wnt/β-CATENIN SIGNALING PATHWAY IN OBESITY

Abstract: The complexity of the adipogenesis mechanism results from the impact of multiple cues, among which an important place is held by the components of the Wnt signaling pathway. The search for potential markers of the development of diseases related to obesity aroused an interest in the study of GSK-3 (glycogen synthase kinase), β-catenin. GSK-3β is an intracellular serine / threonine kinase found in the cytoplasm, nucleus, mitochondria, synthesized in all body tissues and involved in regulating metabolic processe… Show more

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Cited by 2 publications
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“…Considering the involvement of GSK-3α in the pathophysiology of cardiometabolic diseases [6,9], in this study, we analyzed the obtained data on the content of GSK-3α in the blood serum of patients with acute forms of coronary artery disease, the level of which was 2 times lower than in healthy people (277 (238.25-875) pg/mL; p = 0.021); no statistically significant differences were found in patients of groups I and II. It should be noted that at normal levels of LDL and cholesterol, lower concentrations of GSK-3α were recorded, and patients with atherosclerosis had higher GSK-3α values, the highest level of GSK-3α was noted in patients with coronary artery disease and grade 3 obesity.…”
Section: Resultsmentioning
confidence: 99%
“…Considering the involvement of GSK-3α in the pathophysiology of cardiometabolic diseases [6,9], in this study, we analyzed the obtained data on the content of GSK-3α in the blood serum of patients with acute forms of coronary artery disease, the level of which was 2 times lower than in healthy people (277 (238.25-875) pg/mL; p = 0.021); no statistically significant differences were found in patients of groups I and II. It should be noted that at normal levels of LDL and cholesterol, lower concentrations of GSK-3α were recorded, and patients with atherosclerosis had higher GSK-3α values, the highest level of GSK-3α was noted in patients with coronary artery disease and grade 3 obesity.…”
Section: Resultsmentioning
confidence: 99%