Role of Gut Microbiota in the Pharmacological Effects of Natural Products

Pan, Chuyue; Guo, Qing; Lu, Na

doi:10.1155/2019/2682748

Cited by 28 publications

(19 citation statements)

References 89 publications

(96 reference statements)

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“…These compounds are well known to bring beneficial effects to the host by affecting metabolic activities of its gut microbiota. Many previous studies have shown that natural products exert pharmacological effects by modulating the composition of gut microbiota [22,23,24]. Likewise, the potential beneficial effects of JGT on colitis may be partially related to its interaction with gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

Korean Traditional Medicine (Jakyakgamcho-tang) Ameliorates Colitis by Regulating Gut Microbiota

et al. 2019

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The objective of this study was to examine the anti-colitis activity of Jakyakgamcho-tang (JGT) in dextran sulfate sodium (DSS)-induced colitis and explore changes of the gut microbial community using 16S rRNA amplicon sequencing and metabolomics approaches. It was found that treatment with JGT or 5-aminosalicylic acid (5-ASA) alleviated the severity of colitis symptoms by suppressing inflammatory cytokine levels of IL-6, IL-12, and IFN-γ. The non-metric multidimensional scaling analysis of gut microbiome revealed that JGT groups were clearly separated from the DSS group, suggesting that JGT administration altered gut microbiota. The operational taxonomic units (OTUs) that were decreased by DSS but increased by JGT include Akkermansia and Allobaculum. On the other hand, OTUs that were increased by DSS but decreased by 5-ASA or JGT treatments include Bacteroidales S24-7, Ruminococcaceae, and Rikenellaceae, and the genera Bacteroides, Parabacteroides, Oscillospira, and Coprobacillus. After JGT administration, the metabolites, including most amino acids and lactic acid that were altered by colitis induction, became similar to those of the control group. This study demonstrates that JGT might have potential to effectively treat colitis by restoring dysbiosis of gut microbiota and host metabolites.

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Section: Introductionmentioning

confidence: 99%

Korean Traditional Medicine (Jakyakgamcho-tang) Ameliorates Colitis by Regulating Gut Microbiota

et al. 2019

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“…Accumulated evidence supports that the gut microbiome plays pivotal roles in cancer malignancy, via a primary mechanism influencing anti-tumor immunosurveillance [ 51 , 52 ]. Meanwhile, emerging evidence also supports broad pharmacological effects of natural products on gut microbiota, including the microbiota composition, microbial metabolites, intestinal tight junction structure, and mucosal immunology [ 53 ]. In-depth understanding in this regard may resolve a long puzzle of why most natural products exhibit concrete pharmacological effects despite the very limited plasma and tumor exposure.…”

Section: Future Directions That May Open New Opportunities For Naturamentioning

confidence: 99%

Natural Products in Cancer Therapy: Past, Present and Future

Huang

Ding

2021

Nat. Prod. Bioprospect.

378

173

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Natural products, with remarkable chemical diversity, have been extensively investigated for their anticancer potential for more than a half-century. The collective efforts of the community have achieved the tremendous advancements, bringing natural products to clinical use and discovering new therapeutic opportunities, yet the challenges remain ahead. With remarkable changes in the landscape of cancer therapy and growing role of cutting-edge technologies, we may have come to a crossroads to revisit the strategies to understand nature products and to explore their therapeutic utility. This review summarizes the key advancements in nature product-centered cancer research and calls for the implementation of systematic approaches, new pharmacological models, and exploration of emerging directions to revitalize natural products search in cancer therapy.

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“…Given the eubiotic properties of rifamycin and berberine[ 24 , 25 ], this patient was prescribed successive administration of rifampicin (450 mg, once per day) and berberine (0.3 g, thrice per day) with monthly administered GCP (1500 mL polyethylene glycol electrolyte solution per day for 2 d) after his third recurrence. Other employed drugs included lactulose oral solution (45-50 mL per day), inulin (15-20 g per day), and probiotics consisting of Lactobacillus acidophilus, Clostridium butyricum, Bifidobacterium, Bacillus coagulans, and Enterococcus .…”

Section: To the Editormentioning

confidence: 99%

Acquired aplastic anemia: Is bystander insult to autologous hematopoiesis driven by immune surveillance against malignant cells?

Zhao¹,

Sun²,

Ju³

et al. 2020

WJSC

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We previously reported a serendipitous finding from a patient with refractory severe aplastic anemia who had gotten an unexpected hematological response to treatment with gut-cleansing preparations (GCPs). This patient experienced three recurrences over the ensuing one year of intermittent GCP treatments, with each recurrence occurring 7-8 wk from a GCP. After his third recurrence, he was prescribed successive treatment with rifampicin, berberine, and monthly administered GCP for 4 mo, and he developed an erythroid proliferative neoplasma and an overwhelming enteropathy, and eventually died of septic shock. Laboratory investigations had validated the resolution of myelosuppression and the appearance of malignant clonal hematopoiesis. From the treatment process and laboratory investigations, it is reasonably inferred that the engagement of gut inflammation is critically required in sustaining the overall pathophysiology of acquired aplastic anemia probably by creating a chronic inflammatory state. Incorporation of rifampicin, berberine, and monthly GCP into cyclosporine can enhance the immunosuppressive effect. In a subgroup of acquired aplastic anemia patients whose pathogenesis is associated with genotoxic exposure, the suppressed normal hematopoiesis may result from the bystander insult that is mediated by the soluble inflammatory cytokines generated in response to the immunogenic products of damaged hematopoietic cells in the context of chronic inflammatory state and may offer a protective antineoplastic mechanism against malignant proliferation.

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Role of Gut Microbiota in the Pharmacological Effects of Natural Products

Cited by 28 publications

References 89 publications

Korean Traditional Medicine (Jakyakgamcho-tang) Ameliorates Colitis by Regulating Gut Microbiota

Korean Traditional Medicine (Jakyakgamcho-tang) Ameliorates Colitis by Regulating Gut Microbiota

Natural Products in Cancer Therapy: Past, Present and Future

Acquired aplastic anemia: Is bystander insult to autologous hematopoiesis driven by immune surveillance against malignant cells?

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