Role of H-FABP values in determining the etiologic factors of the cardiac injuries

Akpinar, Guleser; Duman, Ali; Gülen, Bedia; Kapçı, Mücahit; Altınbilek, Ertuğrul; Ikizceli, İ̇brahim

doi:10.11604/pamj.2017.26.36.8746

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…In most cases, restoration of sinus rhythm was spontaneous or under medical treatment, within one hour to a week after CABG. Thus, ischemic lesion during open heart surgery should represent a therapeutic objective in order to reduce the occurrence of POAF [14]. Recent studies have shown that H-FABP can be used especially in early diagnosis of acute coronary syndrome, heart failure, liver and kidney lesions, pulmonar y thromboembolism and some kind of intoxications.…”

Section: Resultsmentioning

confidence: 99%

Heart-Type Fatty Acid-Binding Protein (H-FABP) in Patients with Type 2 Diabetes Beneficiaries of Rehabilitation Program Post Coronary Artery Bypass Grafting

Namat¹,

Felea²,

Costache³

et al. 2018

Rev. Chim.

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Heart-type fatty acid-binding protein (H-FABP) is a non-invasive bio-marker, with high sensitivity and specificity, being capable to point out the myocardial injury and to predict major adverse cardiovascular events (MACE). Cardiac rehabilitation program, through a complex and sustained post-interventional management plays an important role in reducing the plasma levels of H-FABP. In the study, which included 120 post-coronary artery bypass (CABG) patients, we analyzed the link between low levels of general post-surgical health status and the presence of cardiovascular risk factors, common biochemical markers, and especially the role played by diabetic status in lowering the plasma H-FABP levels. From the group, 65 patients had been diagnosed with type 2 Diabetes Mellitus (T2DM). The H-FABP values decreased both in diabetics and in non-diabetics between the two phases of CR, 6 months away from CABG. More than half of the patients had important reduction of H-FABP, at 6 months after the onset of CR program. Half of the group registered a smaller reduction of H-FABP, but more noticeable in diabetics. Ischemic lesion during open heart surgery is linked to high levels of H-FABP and with an occurence risk of postoperative atrial fibrillation, that can be also triggered and sustained by multiple endocrine conditions related to aging. Thus, metabolic control should always remain a target of the complex management in cardiac rehabilitation.

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Section: Resultsmentioning

confidence: 99%

Heart-Type Fatty Acid-Binding Protein (H-FABP) in Patients with Type 2 Diabetes Beneficiaries of Rehabilitation Program Post Coronary Artery Bypass Grafting

Namat¹,

Felea²,

Costache³

et al. 2018

Rev. Chim.

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“…In assessment of the H-FABP in relation to BCI, no significance was found between cardiac injury due to blunt thoracic trauma and H-FABP ( P > 0.05); therefore, it is recommended to conduct wide-scale prospective studies for its use in this context. [28]…”

Section: Diagnosticsmentioning

confidence: 99%

Traumatic blunt cardiac injuries: An updated narrative review

Fadel

El‐Menyar

ElKafrawy

et al. 2019

Int J Crit Illn Inj Sci

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Blunt cardiac injury (BCI) is defined as injuries sustained due to blunt trauma to the heart, and it remains unchanged for long time. The spectrum of BCI ranges from a minor “bruise” to specific postcontusion cardiac conditions such as free-wall rupture. This is a narrative review provides a continued and updates details regarding BCIs from 2008 to 2017. For this purpose, a narrative review of literature was conducted using appropriate database for retrieval of articles through systematic search methodology. Autopsy-based studies are very limited. It can be concluded that regardless of the variability in the spectrum of modalities and medical/surgical resources, BCIs diagnosis and management remain a puzzle and needs further prospective studies.

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“…It is also responsible for the synthesis of membranes and mediators, it influences gene expression, and it protects cells during ischemia by inactivating radicals. It is excreted renally and has a half-life of 20 min [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation

Namat

Ciocoiu

et al. 2022

JCDD

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(1) Background: The heart-type fatty acid-binding protein (H-FABP) is a specific myocardial biomarker and high levels indicate ischemia regardless of patient-reported symptoms. Concurrently, major adverse cardiovascular events and surgery such as coronary artery by-pass grafting (CABG) cause substantial psycho-emotional distress e.g., depression and anxiety. Comprehensive cardiac rehabilitation is, therefore, essential to both physical and psychological recovery. (2) Methods: This is a unicentric, prospective study on 120 consecutive post-CABG patients undergoing a 6-month cardiac rehabilitation program based on physical exercise, Mediterranean diet principles, and Q10 coenzyme antioxidant supplements. H-FABP levels, depression, and anxiety scores (Hamilton HAM-D and HAM-A scales) were monitored after surgery and at 6 months. (3) Results: Mean H-FABP dropped from 60.56 to 4.81. Physical ability increased from 1–2 to 4–5 METS. Mean depression and anxiety improved from 15.88 to 6.96 and from 25.13 to 15.68, respectively. Median scores went down 50% for depression and 9% for anxiety. Explored associations between H-FABP and psycho-emotional status were statistically insignificant. (4) Conclusions: patients adhered to the program and improved significantly in all studied aspects. Clinical significance is discussed in the context of countries like Romania, where such programs are limited by systemic and financial constraints. Further research directions are identified.

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Role of H-FABP values in determining the etiologic factors of the cardiac injuries

Cited by 5 publications

References 12 publications

Heart-Type Fatty Acid-Binding Protein (H-FABP) in Patients with Type 2 Diabetes Beneficiaries of Rehabilitation Program Post Coronary Artery Bypass Grafting

Heart-Type Fatty Acid-Binding Protein (H-FABP) in Patients with Type 2 Diabetes Beneficiaries of Rehabilitation Program Post Coronary Artery Bypass Grafting

Traumatic blunt cardiac injuries: An updated narrative review

H-FABP Levels and Psycho-Emotional Improvement of CABG Patients during Cardiac Rehabilitation

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