1991
DOI: 10.1111/1523-1747.ep12480997
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Role of Hair Follicles in the Repigmentation of Vitiligo

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Cited by 305 publications
(266 citation statements)
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“…However, in patients affected by vitiligo, a progressive skin disease with defective pigmentation, the repigmentation process starts from perifollicular areas, thus implying that, during this process, undifferentiated melanocytes in interfollicular epidermis may derive from melanocyte stem cells of the hair follicle bulge area (Falabella & Barona 2009). Consistently, a migration process of bulge melanoblasts towards interfollicular epidermis has been previously observed (Cui et al, 1991). Overall, these observations may suggest that melanoblasts in the hair follicles function as a reservoir population both for the bulb hair follicle and for interfollicular epidermis.…”
Section: Nts and The Origin Of Melanomasupporting
confidence: 85%
“…However, in patients affected by vitiligo, a progressive skin disease with defective pigmentation, the repigmentation process starts from perifollicular areas, thus implying that, during this process, undifferentiated melanocytes in interfollicular epidermis may derive from melanocyte stem cells of the hair follicle bulge area (Falabella & Barona 2009). Consistently, a migration process of bulge melanoblasts towards interfollicular epidermis has been previously observed (Cui et al, 1991). Overall, these observations may suggest that melanoblasts in the hair follicles function as a reservoir population both for the bulb hair follicle and for interfollicular epidermis.…”
Section: Nts and The Origin Of Melanomasupporting
confidence: 85%
“…High melanin content protects the skin from harmful ultraviolet rays owing to the ability to absorb UV radiation and quench the UV-induced intracellular free radicals (1,5,6). Defects in or a lack of melanocytes can lead to pigment disorders, such as piebaldism, albinism, vitiligo, and hair graying (7)(8)(9).…”
Section: Introductionmentioning
confidence: 99%
“…27 As no intrinsic aberrations were observed in the function of integrins on the vitiligo melanocyte cell surface, it follows that conclusions drawn from adhesion and migration studies performed employing control melanocytes will also apply to melanocytes derived from vitiligo patients. This is of major importance as for repigmentation, melanocytes surrounding vitiligo lesions and melanocytes from hair shafts 28 need be stimulated to re-enter vitiligo lesional skin. Observations that LTC-4 and nerve growth factor (NGF) stimulate melanocyte migration 29 are, thus, of great interest for the development of new therapeutic modalities.…”
Section: Discussionmentioning
confidence: 99%