Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways

Duvigneau, J. Catharina; Esterbauer, Harald; Kozlov, Andrey V.

doi:10.3390/antiox8100475

Cited by 75 publications

(55 citation statements)

References 238 publications

(282 reference statements)

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“…Biliverdin is rapidly reduced by biliverdin reductase to produce bilirubin, which can effectively remove peroxyl radicals, thereby inhibiting LPO, attenuating heme-induced oxidative stress, cell activation, and death [ 55 ]. Likewise, the released carbon monoxide activates nuclear factor E2-related factor 2 (Nrf2) signaling, promoting the endogenous antioxidant availability and increasing HO-1 levels [ 58 ]. On the other hand, ROS stimulate ferritin synthesis and iron sequestration, being essential for proper iron homeostasis [ 55 ].…”

Section: Meat Consumption As a Source Of Oxidative Stressmentioning

confidence: 99%

Can Meat and Meat-Products Induce Oxidative Stress?

et al. 2020

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High meat and meat-products consumption has been related to degenerative diseases. In addition to their saturated fatty acids and cholesterol contents, oxidation products generated during their production, storage, digestion, and metabolization have been largely implicated. This review begins by summarizing the concept of meat and meat-products by the main international regulatory agencies while highlighting the nutritional importance of their consumption. The review also dials in the controversy of white/red meat classification and insists in the need of more accurate classification based on adequate scores. Since one of the negative arguments that meat receives comes from the association of its consumption with the increase in oxidative stress, main oxidation compounds (malondialdehyde, thermaloxidized compounds, 4-hydroxy-nonenal, oxysterols, or protein carbonyls) generated during its production, storage, and metabolization, are included as a central aspect of the work. The review includes future remarks addressed to study the effects meat consumption in the frame of diet–gene interactions, stressing the importance of knowing the genetic variables that make individuals more susceptible to a possible oxidative stress imbalance or antioxidant protection. The importance of consumed meat/meat-products in the frame of a personalized nutrition reach in plant-food is finally highlighted considering the importance of iron and plant biophenols on the microbiota abundance and plurality, which in turn affect several aspects of our physiology and metabolism.

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Section: Meat Consumption As a Source Of Oxidative Stressmentioning

confidence: 99%

Can Meat and Meat-Products Induce Oxidative Stress?

et al. 2020

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“…Human heme catabolism is accomplished by the inducible heme oxigenase (HO-1) and, likely to a lesser extent, by the constitutional HO-2 (Duvigneau et al 2019). HO-1 metabolizes the heme group of a variety of hemeproteins including myoglobin, neuroglobin, cytochrome c, cytochrome p450, nitric oxide synthases, and guanylate cyclase.…”

Section: Heme Oxygenase 1 (Ho-1) Carbon Monoxide (Co) and Heme Metabmentioning

confidence: 99%

The role of host defences in Covid 19 and treatments thereof

Dattilo¹

2020

Mol Med

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Hydrogen sulfide (H2S) is a natural defence against the infections from enveloped RNA viruses and is likely involved also in Covid 19. It was already shown to inhibit growth and pathogenic mechanisms of a variety of enveloped RNA viruses and it was now found that circulating H2S is higher in Covid 19 survivors compared to fatal cases. H2S release is triggered by carbon monoxide (CO) from the catabolism of heme by inducible heme oxygenase (HO-1) and heme proteins possess catalytic activity necessary for the H2S signalling by protein persulfidation. Subjects with a long promoter for the HMOX1 gene, coding for HO-1, are predicted for lower efficiency of this mechanism. SARS-cov-2 exerts ability to attack the heme of hemoglobin and other heme-proteins thus hampering both release and signalling of H2S. Lack of H2S-induced persulfidation of the KATP channels of leucocytes causes adhesion and release of the inflammatory cytokines, lung infiltration and systemic endothelial damage with hyper-coagulability. These events largely explain the sex and age distribution, clinical manifestations and co-morbidities of Covid-19. The understanding of this mechanism may be of guidance in re-evaluating the ongoing therapeutic strategies, with special attention to the interaction with mechanical ventilation, paracetamol and chloroquine use, and in the individuation of genetic traits causing increased susceptibility to the disruption of these physiologic processes and to a critical Covid 19. Finally, an array of therapeutic interventions with the potential to clinically modulate the HO-1/CO/H2S axis is already available or under development. These include CO donors and H2S donors and a boost to the endogenous production of H2S is also possible.

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“…HO-1 expression, but not HO-2, is increased in cultured VSM and endothelial cells in response to various stress stimuli ( Christodoulides et al, 1995 ). Similar to SirT1, HO-1 overexpression serves a protective role by virtue of anti-oxidant ( Ferrandiz and Devesa, 2008 ; Bonacasa et al, 2013 ), anti-inflammatory ( Lee et al, 2004 ), anti-apoptotic ( Ferrandiz and Devesa, 2008 ), and anti-proliferative ( Deng et al, 2004 ; Lee et al, 2004 ) effects in endothelial, smooth muscle cells and macrophages in the vascular wall ( Kim et al, 2011 ), by increasing CO and/or biliverdin production or by reducing the pro-oxidant heme levels ( Abraham and Kappas, 2005 ; Duvigneau et al, 2019 ). Like SirT1, HO-1 confers protection in several vascular injury models, such us ischemic heart disease, atherosclerosis, hypertension, diabetes, or vascular proliferative diseases ( Abraham and Kappas, 2005 ; Loboda et al, 2008 ; Kim et al, 2011 ).…”

Section: Sirt1 and Ho-1 In Aortic Aneurysmmentioning

confidence: 99%

The Role of Sirtuin-1 in the Vasculature: Focus on Aortic Aneurysm

et al. 2020

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Sirtuin-1 (SirT1) is a nicotinamide adenine dinucleotide-dependent deacetylase and the best characterized member of the sirtuins family in mammalians. Sirtuin-1 shuttles between the cytoplasm and the nucleus, where it deacetylates histones and nonhistone proteins involved in a plethora of cellular processes, including survival, growth, metabolism, senescence, and stress resistance. In this brief review, we summarize the current knowledge on the anti-oxidant, anti-inflammatory, anti-apoptotic, and antisenescence effects of SirT1 with an emphasis on vascular diseases. Specifically, we describe recent research advances on SirT1-mediated molecular mechanisms in aortic aneurysm (AA), and how these processes relate to oxidant stress and the heme-oxygenase (HO) system. HO-1 and HO-2 catalyze the rate-limiting step of cellular heme degradation and, similar to SirT1, HO-1 exerts beneficial effects in the vasculature through the activation of anti-oxidant, anti-inflammatory, anti-apoptotic, and anti-proliferative signaling pathways. SirT1 and HO-1 are part of an integrated system for cellular stress tolerance, and may positively interact to regulate vascular function. We further discuss sex differences in HO-1 and SirT1 activity or expression, and the potential interactions between the two proteins, in relation to the progression and severity of AA, as well as the ongoing efforts for translational applications of SirT1 activation and HO-1 induction in the treatment of cardiovascular diseases including AA.

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Role of Heme Oxygenase as a Modulator of Heme-Mediated Pathways

Cited by 75 publications

References 238 publications

Can Meat and Meat-Products Induce Oxidative Stress?

Can Meat and Meat-Products Induce Oxidative Stress?

The role of host defences in Covid 19 and treatments thereof

The Role of Sirtuin-1 in the Vasculature: Focus on Aortic Aneurysm

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