Role of hepcidin in the development of anemia in patients with rheumatoid arthritis

Галушко, Е. А.; Александрова, Е. Н.; Kashnikova, L N

doi:10.14412/1995-4484-2012-704

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Aksi IFN-γ dan TGF-β diperantarai melalui jalur protein kinase teraktivasi mitogen p38, sedangkan IFN-γ bekerja melalui jalur Janus-associated kinase (JAK/STAT). Aktivasi jalur ini menyebabkan produksi faktor intraseluler yang meningkatkan apoptosis melalui regulasi transkripsi dan pada akhirnya menyebabkan supresi mieloid (Galushko 2014). Sitokin IL-6 telah diketahui sebagai bagian terpenting dalam patogenesis anemia pada inflamasi kronis.…”

Section: Hasil Dan Pembahasanunclassified

Profil Hematologi, Kadar Besi (Fe), dan Rasio Mieloid: Eritroid Kuda Hiperimun yang digunakan dalam Produksi Plasma Antisera

Arifianto,

Esfandiari,

Wibawan

et al. 2024

Jurnal Sain Veteriner

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Kuda merupakan salah satu hewan yang penting dalam produksi plasma antisera sebagai bahan baku pembuatan serum. Akhir abad ke-19 kuda berperan krusial dalam pengembangan serum pertama terhadap penyakit difteri manusia. Hingga saat ini kuda masih digunakan untuk memproduksi berbagai serum anti-venom, anti-rabies, anti-tetanus, hingga anti-SARS CoV-2. Proses produksi plasma antisera diawali dengan injeksi imunogen pada kuda yang disebut dengan hiperimunisasi. Antibodi dalam jumlah besar yang terbentuk dikoleksi kemudian dipurifikasi untuk digunakan pada manusia. Hiperimunisasi menimbulkan berbagai efek samping, diantaranya adalah penimbunan fibril amiloid pada berbagai jaringan yang dapat mengganggu fisiologi dan fungsi organ tubuh. Sebanyak 12 ekor kuda digunakan dalam penelitian ini dan dibagi menjadi 4 kelompok. Kuda kontrol (n=3) terdiri atas kuda yang belum pernah mendapatkan perlakuan hiperimunisasi, sedangkan 9 kuda lainnya dikelompokkan berdasarkan lamanya waktu produksi plasma antisera dengan metode hiperimunisasi (masing-masing kelompok berjumlah 3 ekor). Kelompok I terdiri atas kuda dengan masa produksi 2-3 tahun, kelompok II terdiri atas kuda dengan masa produksi 4-5 tahun, dan kelompok III terdiri atas kuda dengan masa produksi 6-7 tahun. Sampel darah, serum, dan aspirasi sumsum tulang dianalisis utuk melihat profil eritrosit, Hb, PCV, trombosit, profil besi (besi serum, UIBC, TIBC, saturasi transferin), rasio mieloid:eritroid (M:E) dan persentase retikulosit. Analisis statistik menunjukkan bahwa terdapat perbedaan yang signifikan pada parameter eritrosit dan rasio M:E (P<0,05), sedangkan Hb, trombosit, dan profil besi tidak ditemukan perbedaan yang signifikan (P>0,05). Hal tersebut menunjukkan bahwa perlakuan hiperimunisasi menyebabkan terjadinya anemia non-regeneratif dengan mekanisme supresi eritropoiesis sumsum tulang tanpa memengaruhi komponen besi.

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Section: Hasil Dan Pembahasanunclassified

Profil Hematologi, Kadar Besi (Fe), dan Rasio Mieloid: Eritroid Kuda Hiperimun yang digunakan dalam Produksi Plasma Antisera

Arifianto,

Esfandiari,

Wibawan

et al. 2024

Jurnal Sain Veteriner

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“…The utilization of serum hepcidin is currently being suggested as the most precise serological indicator for distinguishing between anemia of chronic disease (ACD) and iron deficiency anemia (IDA). This academic discussion focuses on the notable laboratory distinctions between ACD (anemia of chronic disease) and IDA (iron deficiency anemia), as well as the anticipated outcomes when both conditions coexist [57,58] .…”

Section: Hepcidinmentioning

confidence: 99%

Prevalence of Anemia: A comprehensive review

Tejavat

2023

Int. J. Clin. Diagn. Pathol.

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Anemia is a prevalent condition associated with inadequate nutrition and global health concerns that impact both emerging and wealthy nations. It presents significant health hazards and poses challenges to social and economic progress. The World Health Organization (WHO) reports that around one-third of the global population is affected by anemia, primarily attributed to inadequate consumption of nutrient-rich diet. The objective of this review is to acquire a deeper understanding of anemia, encompassing its various classifications, etiology, clinical manifestations, and therapeutic interventions, with the intention of disseminating knowledge to the general population on this pathological condition. Anemia, a prevalent public health issue, is known to result in compromised cognitive and psychomotor development, diminished work productivity, and stunted growth in children. The primary etiological factors can be attributed to inadequacies in nutrition and infestations by parasites. The primary etiologies of anemia are nutritional deficiencies; specifically iron deficiency anemia, vitamin B12 deficiency anemia, and folate deficiency anemia.

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“…ВП при РА выявляются у значительной доли пациентов, их наличие может ухудшать прогноз болезни. Важно своевременно их распознавать и безотлагательно начинать лечение [22,23].…”

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Rheumatoid nodules in the lung parenchyma in rheumatoid arthritis

Сатыбалдыев¹,

Ананьева²

2019

Naučno-praktičeskaâ revmatologiâ

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Rheumatoid nodules (RNs) are one of the most common extra-articular manifestations of rheumatoid arthritis (RA), but are rarely located in lung tissue. The development of extra-articular (systemic) manifestations of RA is associated with the high levels of rheumatoid factor and anticyclic citrullinated peptide antibodies. The specific features of the course of RNs in lung tissue are their frequent occurrence with minimally pronounced joint inflammatory changes or remission. In rare cases, RNs are prone to disintegration and suppuration, which may be complicated by the formation of small caverns, hemoptysis, and, if located subpleurally, pneumothorax. In addition, there are publications on the possible relationship of the formation of RNs and their accelerated development to the administration of immunosuppressive drugs (methotrexate, tocilizumab, D-penicillamine, gold salts, leflunomide, infliximab, and other TNF-α inhibitors) and on the association of pulmonary RNs with methotrexate treatment. The paper describes a clinical case of a female patient with RA-systemic sclerosis overlap syndrome and RN formation in lung tissue early at disease onset when the DAS28 target level for RA has been achieved. The atypical outline of a pulmonary nodule has required a differential diagnostic search. The results of imaging RNs in the lung and their dynamics are shown. The given data are discussed.

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Role of hepcidin in the development of anemia in patients with rheumatoid arthritis

Cited by 4 publications

References 16 publications

Profil Hematologi, Kadar Besi (Fe), dan Rasio Mieloid: Eritroid Kuda Hiperimun yang digunakan dalam Produksi Plasma Antisera

Profil Hematologi, Kadar Besi (Fe), dan Rasio Mieloid: Eritroid Kuda Hiperimun yang digunakan dalam Produksi Plasma Antisera

Prevalence of Anemia: A comprehensive review

Rheumatoid nodules in the lung parenchyma in rheumatoid arthritis

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