Role of herpes simplex-1, epstein barr and human cytomegalo viruses in aggressive periodontitis

Dani, Sneha; Dwarakanath, CD; Alampalli, Ramesh Vishwanathmurthy; Bhat, Kishore; An, Shi; Gundannavar, Gayatri

doi:10.14419/ijdr.v1i2.1344

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…2,16 The prevalence of the herpesvirus is shown to be varying in studies conducted all around the globe. The data from the healthy group in our study was similar to the findings of Dani et al, 17 who found 20% of HCMV and 7% EBV prevalence in Indian subjects. In a few studies, EBV is detected in a healthy oral cavity which is similar to our findings, but with no HCMV detection.…”

Section: Discussionsupporting

confidence: 91%

“…The occurrence of herpesvirus is known to vary with different geographical locations, ethnicity, type of periodontal lesion being studied and the viral identification technique employed. 2,7 The current study found the occurrence of both the viruses similar to the previous reports by Sharma et al 9 and Dani et al, 17 however, Bilichodmath et al 10 found higher levels of EBV in chronic periodontitis patients. The findings of the present study were at lower levels as compared to some studies done in other countries.…”

Section: A Study Done By Contreras Et Al In American Patientssupporting

confidence: 89%

“…7,18,19 Although few studies showed similar detection rates of HCMV as in our study, there has been a wide and varied report with high levels of viruses to none in certain population with healthy periodontium. 7,9,17,18,[20][21][22][23] In CP, there have been varied reports with some studies finding very high levels of EBV and HCMV. 10,18,20,21,23 Our results showed significantly higher levels of both the HCMV and the EBV virus in CP as compared to the healthy periodontium but still was lower than the median range as quoted by Slots 2010.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Joshi¹,

Bhat²,

Katti³

et al. 2015

The Journal of Contemporary Dental Practice

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Objective: The identification of new uncultured species and viruses supports the possibility of combination of the herpesvirus-bacterial periodontal infection for periodontitis. The paucity of data and studies with larger sample size in Indian subjects provides an unclear picture of the presence of the herpesvirus in this population. Materials and methods:This was a cross-sectional study consisting of 100 each in the healthy group and chronic periodontitis (CP) group. The subgingival plaque was collected and polymerase chain reaction was performed post deoxyribonucleic acid (DNA) extraction by using specific primers for human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV). The data were analyzed using Fisher's exact test, Mann-Whitney U test and Spearman's coefficient correlation.Results: Human cytomegalovirus and EBV viruses were significantly higher in the CP group as compare to the healthy group. A higher percentage of those with CMV positive had EBV also positive (28.3%) compared to only 9.1% of CMV negative being EBV positive in the CP group. When both the healthy and CP group in total was compared, there was a significant correlation with all clinical parameters. Conclusion:Both the viruses dominated in disease as compared to health were similar to the earlier findings. The CP group had higher pocket depth and clinical attachment loss in the virus positive subjects. These findings could suggest that 91-9620127630, e-mail: drvinayakjoshi@gmail.com virus serves as a prelude to the disease and the combination of the two viruses could play a role in the pathogenesis. Prevalence of Herpesvirus and Correlation with Clinical

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Section: Discussionsupporting

confidence: 91%

Section: A Study Done By Contreras Et Al In American Patientssupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Joshi¹,

Bhat²,

Katti³

et al. 2015

The Journal of Contemporary Dental Practice

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“…The remaining 12 studies were considered for the present metaanalysis. 15,16,18,[40][41][42][43][44][45][46][47][48] They were published in a relatively narrow period, between 2004 and 2020; one of them was performed in Ghana, 40 one in Turkey, 47 three in India, 41,44,48 three in Latin America, 42,43,45 and four in Europe. 15,16,18,46 The characteristics of primary studies are displayed in Table 1.…”

Section: Re Sultsmentioning

confidence: 99%

Herpes simplex virus type 1 in subgingival plaque and periodontal diseases. Meta‐analysis of observational studies

Arduino

Cabras

Lodi

et al. 2022

J of Periodontal Research

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Background and objectives:This meta-analysis of observational studies (PROSPERO registration number CRD42021236054) sought to investigate strength and generalizability of the association of herpes simplex virus type 1 (HSV-1) in subjects with plaque-induced gingivitis and periodontitis, since the data from literature are contrasting. Material and methods:Case-control and cross-sectional studies, investigating HSV-1 in subgingival plaque/crevicular fluid and periodontal status, were searched through MEDLINE via PubMed, Scopus, Web of Science and Google Scholar. From each study the crude odds ratio (OR) with 95% confidence interval (95CI) was extracted, and the pooled OR was assessed for periodontitis, chronic and aggressive, and gingivitis. The meta-analytic method was chosen based on the level of heterogeneity. The generalizability of results, determined by the meta-analysis bias, was investigated through secondary analyses including sensitivity analyses for study quality, publication bias, and study inclusion, and subgroup analyses for quality of scientific journals that published the primary studies, world Region, subgingival plaque sampling method and study design.Results: Twelve studies were included (738 cases, 551 controls). The pooled ORs were 4.4 (95CI, 1.9-10.2) for any periodontitis; specifically, 2.8 (95CI, 1.0-8.3) for chronic periodontitis, 11.8 (95CI,) for aggressive periodontitis and 4.8 (95CI, 2.1-11.0) for gingivitis. These estimates were statistically significant, excluding for chronic periodontitis, resulting marginally significant (p = .05). Secondary analyses on any and aggressive periodontitis, and, partly, chronic periodontitis corroborated the results, while the material was insufficient for secondary analyses on gingivitis. Conclusions:The results obtained indicated that HSV-1 is associated with periodontitis, while data about gingivitis are inconclusive. HSV-1 investigation in subgingival plaque could help assess periodontitis risk and severity and, if causal association were confirmed, could contribute to its control.

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“…Conventional singleplex PCR was applied to amplify and detect a single target gene of EBV, such as EBNA2 [ 31 ] and LMP2 [ 32 ], while multiplex PCR was used to simultaneously amplify target sequences of several periodontopathic bacteria and herpesviruses [ 33 , 34 , 35 , 36 ]. Another PCR technique, the nested PCR, was implemented to increase the specificity of EBV DNA amplification and reduce the non-specific amplification by the involvement of two sets of primers (outer and inner pairs) for the same target [ 37 , 38 , 39 , 40 , 41 ].…”

Section: Polymerase Chain Reaction (Pcr)-based Detection Methodsmentioning

confidence: 99%

Detection of Epstein–Barr Virus in Periodontitis: A Review of Methodological Approaches

et al. 2020

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Periodontitis, an inflammatory condition that affects the structures surrounding the tooth eventually leading to tooth loss, is one of the two biggest threats to oral health. Beyond oral health, it is associated with systemic diseases and even with cancer risk. Obviously, periodontitis represents a major global health problem with significant social and economic impact. Recently, a new paradigm was proposed in the etiopathogenesis of periodontitis involving a herpesviral–bacterial combination to promote long-term chronic inflammatory disease. Periodontitis as a risk factor for other systemic diseases can also be better explained based on viral–bacterial etiology. Significant efforts have brought numerous advances in revealing the links between periodontitis and Epstein–Barr virus (EBV), a gamma herpesvirus ubiquitous in the adult human population. The strong evidence from these studies may contribute to the advancement of periodontitis research and the ultimate control of the disease. Advancing the periodontitis research will require implementing suitable methods to establish EBV involvement in periodontitis. This review evaluates and summarizes the existing methods that allow the detection and diagnosis of EBV in periodontitis (also applicable in a more general way to other EBV-related diseases), and discusses the feasibility of the application of innovative emerging technologies.

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Role of herpes simplex-1, epstein barr and human cytomegalo viruses in aggressive periodontitis

Cited by 6 publications

References 24 publications

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Herpes simplex virus type 1 in subgingival plaque and periodontal diseases. Meta‐analysis of observational studies

Detection of Epstein–Barr Virus in Periodontitis: A Review of Methodological Approaches

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