Role of HIF-1 in Cancer Progression: Novel Insights. A Review

Pezzuto, Aldo; Carico, Elisabetta

doi:10.2174/1566524018666181109121849

Cited by 258 publications

(217 citation statements)

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“…Several interesting results from our study may promote further investigation into the functions and partners of miR-200s, push forward the clinical application of miR-200s and also provide us with more targets and strategies for therapy. Although not perfect, most of the findings from our results have been successfully confirmed by recent experimental literatures [34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51]. To better confirm the predictive power of our approach and understand the mechanisms underlying the initiation and progression of CRC, more large-scale and standard investigations are worth conducting.…”

Section: Discussionsupporting

confidence: 71%

“…It is well established that mTOR signaling, a critical protein in regulating cancer cells, takes part in varieties of fundamental biological activities containing cell death, autophagy, metabolic reprogramming, cell growth, and cell cycle [44]. HIF-1, a transcription factor with important part in response to low oxygen concentrations, or hypoxia, play significant roles in normal tissue development and function and cancer progression [45]. Activation of the HIF-1 pathway has been considered as an attractive therapeutic target [46].…”

Section: Discussionmentioning

confidence: 99%

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Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer

Peng

Cheng

et al. 2020

Cancer Cell Int

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Background: Accumulating evidence has demonstrated that could serve as promising molecular biomarkers for cancer prognosis. Nevertheless, the associations between miR-200s expression and colorectal cancer (CRC) prognosis remain controversial. Methods:We applied two mainstream approaches combining meta-analysis and bioinformatics analysis to answer whether miR-200s were associated with the prognosis of CRC patients and why miR-200s could be used as prognostic biomarkers for CRC. Results:Consequently, low expression of miR-200s was associated with unfavorable overall survival (OS) in CRC patients (HR: 1.09; 95% CI 1.01-1.17; P = 0.025). According to the subgroup analysis, the prognostic role of miR-200s was more significant for tissue samples, large samples, American patients and miR-200a subgroups. Then the target genes of miR-200s were predicted and applied for functional enrichment analyses. The results showed that the target genes of miR-200s were mainly enriched into some vital ontology subjects such as regulation ability, key cell structures and binding function. Moreover, a series of important signaling pathways were identified, which were significantly linked with the initiation and progression of CRC. Additionally, a protein-protein interaction (PPI) network of miR-200s targets was constructed to screen hub genes and modules. The identified hub genes and modules were validated to be highly involved in the occurrence and development of CRC.Conclusions: Current evidences revealed that miR-200s could be promising biomarkers for CRC prognosis. However, the findings still need to be validated with more larger-scale prospective studies and biological experiments before miR-200s could be applied into clinical application.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer

Peng

Cheng

et al. 2020

Cancer Cell Int

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“…HIF-1 regulates oxygen homeostasis and is the key factor mediating the mammalian hypoxic response [235]. HIF-1 has roles in inflammation, cancer, angiogenesis and cardiovascular disease [236,237]. Furthermore, roles for HIF have been identified in bacterial infections [235] and a link between pathogenic agents and cancer has been identified, as viruses, bacteria and parasites may deregulate HIF-1 signalling associated cancer cells [238].…”

Section: Discussionmentioning

confidence: 99%

Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination

Criscitiello

Kraev

Lange

2020

IJMS

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The bovine immune system is known for its unusual traits relating to immunoglobulin and antiviral responses. Peptidylarginine deiminases (PADs) are phylogenetically conserved enzymes that cause post-translational deimination, contributing to protein moonlighting in health and disease. PADs also regulate extracellular vesicle (EV) release, forming a critical part of cellular communication. As PAD-mediated mechanisms in bovine immunology and physiology remain to be investigated, this study profiled deimination signatures in serum and serum-EVs in Bos taurus. Bos EVs were poly-dispersed in a 70-500 nm size range and showed differences in deiminated protein cargo, compared with whole sera. Key immune, metabolic and gene regulatory proteins were identified to be post-translationally deiminated with some overlapping hits in sera and EVs (e.g., immunoglobulins), while some were unique to either serum or serum-EVs (e.g., histones). Protein-protein interaction network analysis of deiminated proteins revealed KEGG pathways common for serum and serum-EVs, including complement and coagulation cascades, viral infection (enveloped viruses), viral myocarditis, bacterial and parasitic infections, autoimmune disease, immunodeficiency intestinal IgA production, B-cell receptor signalling, natural killer cell mediated cytotoxicity, platelet activation and hematopoiesis, alongside metabolic pathways including ferroptosis, vitamin digestion and absorption, cholesterol metabolism and mineral absorption. KEGG pathways specific to EVs related to HIF-1 signalling, oestrogen signalling and biosynthesis of amino acids. KEGG pathways specific for serum only, related to Epstein-Barr virus infection, transcription mis-regulation in cancer, bladder cancer, Rap1 signalling pathway, calcium signalling pathway and ECM-receptor interaction. This indicates differences in physiological and pathological pathways for deiminated proteins in serum-EVs, compared with serum. Our findings may shed light on pathways underlying a number of pathological and anti-pathogenic (viral, bacterial, parasitic) pathways, with putative translatable value to human pathologies, zoonotic diseases and development of therapies for infections, including anti-viral therapies.

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“…The master regulator of neovascularisation, HIF, is a transcription factor that that plays an integral role in the body's response to low oxygen concentrations (i.e., hypoxia) [196,197]. Active HIF is composed of of two subunits: HIF-α and HIF-1/ARNT.…”

Section: Hypoxia-inducible-factor (Hif) Pathwaymentioning

confidence: 99%

Honokiol: A Review of Its Anticancer Potential and Mechanisms

Ong

Lee

Tang

et al. 2019

Cancers

132

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Cancer is characterised by uncontrolled cell division and abnormal cell growth, which is largely caused by a variety of gene mutations. There are continuous efforts being made to develop effective cancer treatments as resistance to current anticancer drugs has been on the rise. Natural products represent a promising source in the search for anticancer treatments as they possess unique chemical structures and combinations of compounds that may be effective against cancer with a minimal toxicity profile or few side effects compared to standard anticancer therapy. Extensive research on natural products has shown that bioactive natural compounds target multiple cellular processes and pathways involved in cancer progression. In this review, we discuss honokiol, a plant bioactive compound that originates mainly from the Magnolia species. Various studies have proven that honokiol exerts broad-range anticancer activity in vitro and in vivo by regulating numerous signalling pathways. These include induction of G0/G1 and G2/M cell cycle arrest (via the regulation of cyclin-dependent kinase (CDK) and cyclin proteins), epithelial-mesenchymal transition inhibition via the downregulation of mesenchymal markers and upregulation of epithelial markers. Additionally, honokiol possesses the capability to supress cell migration and invasion via the downregulation of several matrix-metalloproteinases (activation of 5 AMP-activated protein kinase (AMPK) and KISS1/KISS1R signalling), inhibiting cell migration, invasion, and metastasis, as well as inducing anti-angiogenesis activity (via the down-regulation of vascular endothelial growth factor (VEGFR) and vascular endothelial growth factor (VEGF)). Combining these studies provides significant insights for the potential of honokiol to be a promising candidate natural compound for chemoprevention and treatment.

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Role of HIF-1 in Cancer Progression: Novel Insights. A Review

Cited by 258 publications

References 0 publications

Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer

Integrated characterization and validation of the prognostic significance of microRNA-200s in colorectal cancer

Post-Translational Protein Deimination Signatures in Serum and Serum-Extracellular Vesicles of Bos taurus Reveal Immune, Anti-Pathogenic, Anti-Viral, Metabolic and Cancer-Related Pathways for Deimination

Honokiol: A Review of Its Anticancer Potential and Mechanisms

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