Role of histamine in heartworm extract-induced shock in dogs

Kitoh, Katsuya; Katoh, Hiroko; Kitagawa, Hitoshi; Nagase, Masayuki; Sasaki, Nobuo; Sasaki, Yoshihide

doi:10.2460/ajvr.2001.62.770

Cited by 9 publications

(8 citation statements)

References 18 publications

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“…Tissue cultures of the liver were performed and yielded a very light growth of Enterococcus cecorum and Clostridium perfringens , which were interpreted as post‐mortem contaminates. The histopathologic findings were supportive of the clinical diagnosis of anaphylaxis, with acute haemorrhage secondary to focal hepatic rupture having played a pivotal role in the patient's progression and demise (Dean & Webb, 1924; Kitoh et al., 1998).…”

Section: Case Summarymentioning

confidence: 68%

Acute hepatic rupture causing hemoperitoneum in a dog with anaphylaxis

Padmanabhan,

Smith,

Wurlod

et al. 2024

Veterinary Medicine & Sci

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A 2‐year‐old spayed female Siberian Husky was presented with a history of acute onset lethargy, collapse, haematochezia and vomiting. The patient was severely tachycardic and hypotensive. Point‐of‐care ultrasound revealed gallbladder wall thickening and peritoneal effusion consistent with haemorrhage on subsequent abdominocentesis. Despite attempted medical stabilization over the course of several hours, including blood products and multiple autotransfusions, the patient progressed to cardiopulmonary arrest. The dog was successfully resuscitated but was subsequently euthanized. Necropsy revealed a severe, acute hemoperitoneum secondary to rupture of the left lateral liver lobe. A tear in the hepatic capsule was identified along with a large hematoma. A single adult nematode, consistent with Dirofilaria immitis, was found in a pulmonary vessel in the right caudal lung lobe. The remaining necropsy findings were supportive of the clinical diagnosis of anaphylaxis. This report details a case, with necropsy findings, supporting a diagnosis of anaphylaxis and severe, refractory hemoperitoneum resulting from hepatic rupture. Acute hepatic rupture should be considered in cases of anaphylaxis‐related hemoperitoneum.

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Section: Case Summarymentioning

confidence: 68%

Acute hepatic rupture causing hemoperitoneum in a dog with anaphylaxis

Padmanabhan,

Smith,

Wurlod

et al. 2024

Veterinary Medicine & Sci

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“…Various veterinary studies have measured histamine levels in canine plasma/serum using immunoassays originally developed for human samples (e.g., opioid-induced anaphylactoid reactions; cardiovascular injuries; heartworm infections; mast cell tumors) [ 27 , 28 , 29 , 30 ]. To the best of our knowledge, serum histamine concentrations have never been reported in naturally occurring cases of anaphalytic reaction, to a drug or other stimuli.…”

Section: Humoral In Vitro Testsmentioning

confidence: 99%

In Vitro Research Tools in the Field of Human Immediate Drug Hypersensitivity and Their Present Use in Small Animal Veterinary Medicine

Lavergne

2016

Veterinary Sciences

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Drug hypersensitivity reactions (DHR) are immune-mediated idiosyncratic adverse drug events. Type I DHR are often referred to as “immediate” and involve B lymphocyte-secreted IgE that bind to the membrane of basophils and mast cells, inducing their degranulation. This review presents various in vitro tests that were developed in the field of human type I HS and implemented as clinical diagnostic tools in human cases of immediate DHR. The respective strengths and weaknesses of each test will be discussed in parallel of validation data such as specificity and sensitivity whenever available. Some of them have also been used as diagnostic tools in veterinary medicine, but not in cases of immediate DHR. Most of these diagnostic tools can be categorized into humoral and cellular tests. The former tests measure serum concentrations of factors, such as histamine, tryptase, and drug-specific IgE. The latter assays quantify markers of drug-induced basophil activation or drug-specific lymphocyte proliferation. Pharmacogenetic markers have also been investigated in immediate DHR, but not as extensively as in non-immediate ones. Throughout, practical aspects and limitations of the tests, as well as sensitivity and specificity parameters, will be presented. In addition, the experience of veterinary medicine with these diagnostic tools will be summarized. However, to date, none of them has ever been reported in a veterinary case of type I DHR.

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“…Parasitic materials are foreign antigens that may trigger a type I immunoglobulin E-mediated hypersensitivity reaction. Dirofilaria immitis extract can result in shock and elevated plasma histamine level in dogs, 7 while hydatid cyst (Echinococcus spp) rupture has been associated with anaphylactic shock. 8 We believe the partial breach of the parasitic tissue envelope during our surgical dissection led to contact of parasitic material with host tissue.…”

Section: Case Reportmentioning

confidence: 99%