Role of human milk components in gastrointestinal development: Current knowledge and future NEEDS

Donovan, Sharon M.

doi:10.1016/j.jpeds.2006.06.052

Cited by 98 publications

(78 citation statements)

References 167 publications

(225 reference statements)

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“…Milk from animals is also transformed into various dairy products for infant and adult human consumption. Aside from the nutritious value consisting of basic proteins, lipids and saccharides, milk contains also numerous biologically active substances, such as imunoglobulins, enzymes, antimicrobial peptides, oligosaccharides, hormones, cytokines and growth factors (Donovan, 2006;Pouliot and Gauthier, 2006;Tunick and Van Hekken, 2014).…”

Section: Introductionmentioning

confidence: 99%

Potential health benefits of sphingolipids in milk and dairy products

Potočki¹

2016

Mljekarstvo

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Sphingolipids are found in all eukaryotic and some prokaryotic cells. Milk and dairy products are one of the most important sources of sphingolipids. This compounds participate in a variety of indispensable metabolic, neurological, and intracellular signaling processes. Sphingolipids and their derivatives are highly bioactive compounds with anti-cancer, bacteriostatic and cholesterol-lowering properties. Therefore, this review focuses on the potential health benefits of the milk and dairy sphingolipids.

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Section: Introductionmentioning

confidence: 99%

Potential health benefits of sphingolipids in milk and dairy products

Potočki¹

2016

Mljekarstvo

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“…While growth is driven primarily via cell proliferation, apoptosis plays an important role in homeostasis of intestinal epithelia [24]. Human milk components support appropriate intestinal development by promoting both growth and functional differentiation [25]. Recent studies have suggested that HMO function to down-regulate intestinal proliferation and promote differentiated epithelial cell function [4].…”

Section: Discussionmentioning

confidence: 99%

Individual and Combined Effects of Nucleotides and Human Milk Oligosaccharides on Proliferation, Apoptosis and Necrosis in a Human Fetal Intestinal Cell Line

Hester¹,

Donovan²

2012

FNS

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Nucleotides (NT) and human milk oligosaccharides (HMO) individually affect epithelial cell growth, but their combined effects had not been studied. Herein, the impact of NT and HMO on cell proliferation, apoptosis, necrosis and cell cycle in the fetal epithelial cell line (FHs-74 Int) was determined. Cells were incubated with media containing 2.5% FBS and no epidermal growth factor (Control); fucosyllactose (FL) mix [85% 2'FL/15% 3'FL], sialyllactose (SL) mix [40% 6'SL/10% 3'SL/50% sialic acid (SA)] or LNnT at 125, 250, 500 or 1000 μg/mL with and without 250 μg/mL NT (43% CMP, 18.5% UMP, 16.4% AMP, and 22.0% GMP) for 24 or 72 h. NT alone significantly increased proliferation, but did not affect cell cycle or apoptosis/necrosis. All HMO treatments at 1000 μg/mL significantly decreased proliferation and some were also inhibitory at 250 or 500 μg/mL. When NT and HMO were simultaneously added, NT ameliorated the anti-proliferative effect of HMO. FL significantly increased cells in S phase and SL and LNnT treatments significantly increased cells in G2/M and S phases, which concomitantly decreased cells in G0/G1. HMO with NT significantly decreased the percent of cells in the G2/M phase compared to HMO alone. Higher HMO doses significantly increased the percentage of apoptotic and necrotic cells compared to control. In conclusion, HMO reduced cell proliferation and this effect is partially ameliorated by NT. It appears that HMO initially induced apoptosis/necrosis, which was later evidenced by G2/M cell cycle arrest and decreased proliferation.

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“…Widdowson et al documented the marked increase in gastrointestinal weight, length and protein as well as DNA content of colostrum fed neonatal piglets [27]. Interestingly, EGF is resistant to degradation within gastric milieu of the preterm infant which suggests that milk born EGF may retain bioactivity in the neonatal GIT [28].Another interesting observation is the evidence of higher levels of VEGF and other growth factors in the milk of mothers who have given birth to preterm infants than in the milk of the mothers who have delivered at term [29,30]. Exposure of the neonate to the bacteria during birth and immunological factors in the breast milk, promote the maturation of the infant's gut and gut associated immune system.…”

Section: Physiology Of Gut Maturationmentioning

confidence: 99%

“Human Milk Component (HMC) Therapy”: A Novel Treatment for Gut Maturation of Preterm Infants

Manohar¹,

Tukaram²,

Satish³

et al. 2014

J Neonatal Biol

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Even though the process of gut maturation starts right from intrauterine life, it really gets accelerated only after birth through enteral route. The preterm infants as well as infants with intrauterine growth restriction and those who had absent or reversed umbilical cord flow during their intrauterine stay are the candidates to have immature gut. They are also prone to the complications like feeding intolerance and necrotizing enterocolities.It is well established that the human milk due to the presence of growth factors and cellular components, play important role in the process of gut maturation. With this background, we have hypothesised and proposed the concept of Human Milk Component (HMC) isolation and therapy for gut maturation in preterm infants. The aqueous fraction of human milk rich in growth factors and bioactive substances and the cellular fraction rich in different kinds of cells including mesenchymal stem cells are isolated. They are given through the feeding tube to the infants with immature gut.The aqueous component of human milk acts by a passive mechanism while the cellular component acts by an active mechanism. This concept further strengthens the importance of human milk.

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Role of human milk components in gastrointestinal development: Current knowledge and future NEEDS

Cited by 98 publications

References 167 publications

Potential health benefits of sphingolipids in milk and dairy products

Potential health benefits of sphingolipids in milk and dairy products

Individual and Combined Effects of Nucleotides and Human Milk Oligosaccharides on Proliferation, Apoptosis and Necrosis in a Human Fetal Intestinal Cell Line

“Human Milk Component (HMC) Therapy”: A Novel Treatment for Gut Maturation of Preterm Infants

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