Role of Human papilloma virus Infection and Altered Methylation of Specific Genes in Esophageal Cancer

Prevalence of Human Papillomavirus 16 in Esophageal Cancer Among the Chinese Population: a Systematic Review and Meta-analysis

“…Interestingly, results of this meta-analysis showed that more than 35% of esophageal cancer cases infected with HPV 16, indicating a high level of HPV 16 infection in esophageal cancer cases of China. Our results were consistent with studies conducted in other Asian countries, which also found that HPV infection rates in esophageal cancer were relatively high (Yahyapour et al, 2012;Mohiuddin et al, 2013). Findings in these studies increase the evidence that HPV is involved in esophageal carcinogenesis.…”

Detection of human papillomavirus infection by molecular tests and its relation to colonic polyps and colorectal cancer

“… 23 , 24 Other types of HPV, such as low-risk (L-R) or non-oncogenic HPV6 and HPV11, induce benign ano-genital warts and are rarely found in ano-genital malignancies. 25 The HPV DNA has been detected in tumor tissues of head and neck cancers, 26 oral cancers, 27 esophageal cancers, 28 and some skin cancers, 29 as well as lung cancers. 30 Even though HPV DNA has been previously detected in CRC tissues by in situ hybridization 21 , 31 and PCR, 18 , 32 , 33 it was not detectable by regular PCR in another study by Snietura et al 34 and a survey of HPV16 virus-like particle antibodies in patients with epithelial cancers also failed to provide an association between HPV and CRC.…”

Analysis of TP53 Polymorphisms in North Indian Sporadic Esophageal Cancer Patients

“…p.R72P polymorphism has also been reported to be associated with risk of cervical cancer development in Human papillomavirus (HPV) 16 infected women (Chansaenroj et al, 2013). In esophageal cancer, HPV may have a role only in the presence of altered promoter methylation of Aurora A and tobacco use (Mohiuddin et al, 2013).…”