Role of Human Papillomavirus and p16 Staining in a Patient With Head and Neck Cancer Presenting With a Synchronous Lung Nodule: A Case Report and Review of the Literature

Bonomi, Marcelo; Abbott, Rachel W.; Patsias, Alexis; Misiukiewicz, Krzysztof; Demicco, Elizabeth G.; Zhang, David; Kaufman, Andrew; Genden, Eric M.; Posner, Marshall R.

doi:10.1200/jco.2013.50.0231

Cited by 4 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because its high sensitivity for HPV, we could assert that P16ink4a a surrogate marker for HPVhr 16 in NPC and that resultis compatible with other studies like (Walline, Komarck et al, 2013, on the other hand it was not the same conclusion in studies like Bonomi and his colleagues' study [23], and our explanation is because of various reasons, like size of sample, criteria of expression and variety of methodology used in detecting both the P16ink4a marker and HPVHR 16 virus.…”

Section: Discussion Hpvhr 16 Expression In Nasopharyngeal Carcinomasupporting

confidence: 85%

The Diagnostic Role of P16ink4a in Detecting High-Risk HPV16 in a Group of Syrian Nasopharyngeal Carcinoma Patients

Mohammad¹

2014

IJDOS

View full text Add to dashboard Cite

Introduction: P16ink4a is a tumor suppressor gene, and it plays a critical role in cell cycle organizing and aging through the regulation of the Cyclin-Dependent Kinase (CDK) 4/6 and Cyclin D complexes. its inactivation corresponds with human carcinogenesis. The overexpression of p16 is considered to be a useful marker to investigate human papilloma virus (HPV) in certain cancers, but its role in nasopharyngeal cancer patients' outcomes is still unclear. Objectives: We aimed in this study to detectHPV high risk type16 expression in a sample of 89 nasopharyngeal carcinoma Syrian patients, and to detect expression of P16ink4a in the same sample. After that, we studied the correlation between the two expressions of HPV and P16ink4a and the power ofcorrelation if existed. Materials and Methods: Eighty n patients with nasopharyngeal carcinoma (NPC) treated in al Moasat universal hospital between 2010 to 2017 were chosen. To investigate the expression of P16ink4aand high-riskHPV 16 (HPVhr 16), we used immunohistochemistry staining. We evaluate the diagnostic role of p16 by discussing the expression profile of p16 in a group of NPC Syrian patients, especially those with HPVhr 16 positive expression . Results:The results of this study showed that the ratio of HPVhr 16 positive expression in 89 patients was 13.5% ,and P16ink4a positive expression was 15.7%, and there was a positive, good correlation between expression of both HPVhr and P16ink4a, so it could be an alternative aid to detect HPVhr16 in paraffin embedded formalin sections. Nonetheless more studies are needed to evaluate the importance of the lack of HPVhr 16 and P16ink4aexpression when correlate with stages of the cancer and other clinical data. Conclusions:The results of this study showed thatratio of HPVhr 16expression is 13.5 % and it is considered a weak percentage but it motivate other studies to assure the good prognosis of patients with no virus existence .Expression of P16ink4a is 15.7% and it can be a surrogate marker for HPVhr 16 in the sample of 89 NPC patients. More studies are needed to correlate prognosis with presence of P16ink4a.

show abstract

Section: Discussion Hpvhr 16 Expression In Nasopharyngeal Carcinomasupporting

confidence: 85%

The Diagnostic Role of P16ink4a in Detecting High-Risk HPV16 in a Group of Syrian Nasopharyngeal Carcinoma Patients

Mohammad¹

2014

IJDOS

View full text Add to dashboard Cite

show abstract

“…However, HPV status may not be evident if a patient undergoes workup for a pulmonary nodule outside the institution where he/she was treated for HNSCC, as occurred for two patients described here. Moreover, distant metastases have rarely been reported as the initial presentation of HNSCC . In such cases, other clinical variables can suggest HPV as an etiology.…”

Section: Discussionmentioning

confidence: 99%

Metastatic HPV‐related head and neck squamous cell carcinoma to the lung and mediastinal lymph nodes in aspirated cytology material: A diagnostic pitfall

Banet

Rooper

Maleki

2016

Diagnostic Cytopathology

View full text Add to dashboard Cite

Metastatic HPV-related HNSCC to the lung and mediastinal lymph nodes share the characteristic basaloid, minimally keratinizing morphology seen in Primary HNSCC cytology. Poorly differentiated pulmonary squamous cell carcinoma and neuroendocrine carcinomas are the primary differentials. Although primary lung neoplasms are not HPV-related, p16 positivity can be seen in both squamous cell and small cell lung carcinomas. HPV ISH allows definitive diagnosis of metastatic HPV-related HNSCC.

show abstract

“…Based on the clonal evolution theory, two tumors derived from a common clone suggest metastasis, while distinct clones indicate multiple primary cancers. Thus, several molecular markers, such as TP53 mutations 9 , 10 , P53/P16 immunohistochemistry 11 , HPV genotyping 12 , 13 , gene expression 14 , and loss of heterozygosity (LOH) involving microsatellite markers 15 , have been analyzed to distinguish SPT from LM in patients with double squamous cell carcinomas (SCCs). However, these molecular markers cannot provide a convincing conclusion for all patients, due to limited numbers of alterations analyzed and the existence of intratumor heterogeneity 16 .…”

Section: Introductionmentioning

confidence: 99%

Identification of second primary tumors from lung metastases in patients with esophageal squamous cell carcinoma using whole-exome sequencing

Xue

Fan

et al. 2020

Theranostics

View full text Add to dashboard Cite

Esophageal squamous cell carcinoma (ESCC) patients with a synchronous or metachronous lung tumor can be diagnosed with lung metastasis (LM) or a second primary tumor (SPT), but the accurate discrimination between LM and SPT remains a clinical dilemma. This study aimed to investigate the feasibility of using the whole-exome sequencing (WES) technique to distinguish SPT from LM. Methods: We performed WES on 40 tumors from 14 patients, including 12 patients with double squamous cell carcinomas (SCCs) of the esophagus and lung (lymph node metastases were sequenced as internal controls) diagnosed as LM according to pathological information and 2 patients with paired primary ESCC and non-lung metastases examined as external controls. Results: Shared genomic profiles between esophageal (T) and lung (D) tumors were observed in 7 patients, suggesting their clonal relatedness, thus indicating that the lung tumors of these patients should be LM. However, distinct genomic profiles between T and D tumors were observed in the other 5 patients, suggesting the possibility of SPTs that were likely formed through independent multifocal oncogenesis. Conclusions: Our data demonstrate the limitations and insufficiency of clinicopathological criteria and that WES could be useful in understanding the clonal relationships of multiple SCCs.

show abstract

Role of Human Papillomavirus and p16 Staining in a Patient With Head and Neck Cancer Presenting With a Synchronous Lung Nodule: A Case Report and Review of the Literature

Cited by 4 publications

References 16 publications

The Diagnostic Role of P16ink4a in Detecting High-Risk HPV16 in a Group of Syrian Nasopharyngeal Carcinoma Patients

The Diagnostic Role of P16ink4a in Detecting High-Risk HPV16 in a Group of Syrian Nasopharyngeal Carcinoma Patients

Metastatic HPV‐related head and neck squamous cell carcinoma to the lung and mediastinal lymph nodes in aspirated cytology material: A diagnostic pitfall

Identification of second primary tumors from lung metastases in patients with esophageal squamous cell carcinoma using whole-exome sequencing

Contact Info

Product

Resources

About