Role of <i>Momordica charantia</i> in maintaining the normal levels of lipids and glucose in diabetic rats fed a high-fat and low-carbohydrate diet

Chaturvedi, Padmaja

doi:10.1080/09674845.2005.11732698

Cited by 37 publications

(19 citation statements)

References 7 publications

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“…Correspondence among perceived healthiness, number of medicinal claims, and perceived taste of the recorded South-Asian vegetables: ( ) vegetables whose taste is perceived as "soft, bland, sweet"; ( ) vegetables whose taste is perceived as bitter; (᭹) vegetables whose taste is perceived as aromatic ("like aniseeds"). Plant codes are reported in Table 2. many bio-scientific studies conducted during the last decade have confirmed them (Grover and Yadav, 2004;Chaturvedi, 2005).…”

Section: Traditional Strategies To Manage Diabetesmentioning

confidence: 79%

Medicinal perceptions of vegetables traditionally consumed by South-Asian migrants living in Bradford, Northern England

Pieroni

Houlihan

Ansari

et al. 2007

Journal of Ethnopharmacology

101

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Section: Traditional Strategies To Manage Diabetesmentioning

confidence: 79%

Medicinal perceptions of vegetables traditionally consumed by South-Asian migrants living in Bradford, Northern England

Pieroni

Houlihan

Ansari

et al. 2007

Journal of Ethnopharmacology

101

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“…We and others have demonstrated that besides improving glucose and lipid metabolism [26,30-32], BMJ is also effective in improving hyperlipidemia in diabetic and obese rodents as well as reduces body weights in mice fed high-fat diet [24,25,33]. However, the effects of bitter melon on human adipocytes have not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes

Nerurkar

Lee

Nerurkar

2010

BMC Complement Altern Med

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BackgroundEscalating trends of obesity and associated type 2 diabetes (T2D) has prompted an increase in the use of alternative and complementary functional foods. Momordica charantia or bitter melon (BM) that is traditionally used to treat diabetes and complications has been demonstrated to alleviate hyperglycemia as well as reduce adiposity in rodents. However, its effects on human adipocytes remain unknown. The objective of our study was to investigate the effects of BM juice (BMJ) on lipid accumulation and adipocyte differentiation transcription factors in primary human differentiating preadipocytes and adipocytes.MethodsCommercially available cryopreserved primary human preadipocytes were treated with and without BMJ during and after differentiation. Cytotoxicity, lipid accumulation, and adipogenic genes mRNA expression was measured by commercial enzymatic assay kits and semi-quantitative RT-PCR (RT-PCR).ResultsPreadipocytes treated with varying concentrations of BMJ during differentiation demonstrated significant reduction in lipid content with a concomitant reduction in mRNA expression of adipocyte transcription factors such as, peroxisome proliferator-associated receptor γ (PPARγ) and sterol regulatory element-binding protein 1c (SREBP-1c) and adipocytokine, resistin. Similarly, adipocytes treated with BMJ for 48 h demonstrated reduced lipid content, perilipin mRNA expression, and increased lipolysis as measured by the release of glycerol.ConclusionOur data suggests that BMJ is a potent inhibitor of lipogenesis and stimulator of lipolysis activity in human adipocytes. BMJ may therefore prove to be an effective complementary or alternative therapy to reduce adipogenesis in humans.

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“…Bitter melon is a traditional plant used by ayurvedic doctors of medicines to benefit various conditions including diabetes [2]. The effect of bitter melon on various diabetes associated cardiovascular risk factors like plasma lipids, obesity and insulin resistance is known [3,4] and the present study is designed to determine the effect of bitter melon on a recently investigated cardiovascular (CV) risk marker/factor, sialic acid. Sialic acid is used to be a group name for acetylated derivatives of neuraminic acid and the serum level of it is increased in type2 diabetes mellitus [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Bitter Melon (Momordica Charantia) Reduces Serum Sialic Acid in Type2 Diabetics: Evidence to Delay the Process of Atherosclerosis

Rahman¹,

Bashir²,

Salman³

et al. 2011

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More than 1000 herbal products have been used by diverse cultures of the world to treat hyperglycemia and among them bitter melon (Momordica charantia) is one of the most popular herbal resource. The beneficial effects of bitter melon is not limited to hypoglycaemia only, but it also ameliorates diet induced obesity, insulin resistance and exhibit cardioprotective effects. The present study attempts to investigate the effect of bitter melon fruit juice on a newly investigated risk factor, sialic acid in type2 diabetics. A total of 40 type2 diabetic patients, divided into group A (n = 20) and group B (n = 20) were investigated during the present study. The patients of group A were following bitter melon fruit juice treatment along with diet control, whereas the patients of group B were on diet control only. Serum sialic acid (SSA) decreased in group A from 66.20 ± 2.30 mg/dl to 63.50 ± 2.10 mg/dl (<0.11) but, increased in group B from 66.50 ± 1.70 mg/dl to 68.20 ± 2.50 mg/dl (<0.12), compared to baseline. Post-treatment between group comparison revealed a significant difference (<0.05). The beneficial effects on fasting plasma glucose (FPG) and glycohemoglobin (HbA1-c) were also greater in group A compared to group B as was the case with blood lipids, weight and blood pressure. The study provides another mechanism for the cardioprotective effect of bitter melon and further strengthens its value in the management of type2 diabetes

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Role of Momordica charantia in maintaining the normal levels of lipids and glucose in diabetic rats fed a high-fat and low-carbohydrate diet

Cited by 37 publications

References 7 publications

Medicinal perceptions of vegetables traditionally consumed by South-Asian migrants living in Bradford, Northern England

Medicinal perceptions of vegetables traditionally consumed by South-Asian migrants living in Bradford, Northern England

Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by modulating adipogenic genes

Bitter Melon (Momordica Charantia) Reduces Serum Sialic Acid in Type2 Diabetics: Evidence to Delay the Process of Atherosclerosis

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